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Cell Transplantation for Neurological Disorders pp 19–30Cite as

Fetal Nigral Transplantation in Parkinson’s Disease

The USF Pilot Program (12- to 24-Month Evaluation)

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

We are conducting a pilot study to evaluate the safety and efficacy of fetal transplantation in Parkinsons disease (PD) (1). Six patients have undergone bilateral fetal nigral transplantation into the postcommissural putamen (PCP). PD was diagnosed according to the Core Assessment Program for Intracerebral Transplantation (CAPIT) criteria (2). All patients had two of three cardinal features (resting tremor, rigidity, bradykinesia) and experienced benefit in response to levodopa (l-DOPA) therapy. Entry criteria included the presence of predictable motor fluctuations, Hoehn-Yahr stage III or better while “on,” and clinically meaningful disability during the “off” state. All patients were receiving a stable dose of l-DOPA/carbidopa for a minimum of 3 mo prior to study entry and could not be improved with further medication changes. All subjects signed informed consent.

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Authors
  1. Robert A. Hauser
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  2. C. Warren Olanow
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  3. Barry J. Snow
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  4. Thomas B. Freeman
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Editor information

Editors and Affiliations

  1. Division of Neurosurgery, Department of Pharmacology and Experimental Therapeutics, The Neuroscience Program, University of South Florida, Tampa, FL, USA

    Thomas B. Freeman MD

  2. Departments of Clinical Neurosciences and Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    Håkan Widner MD, PhD

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Hauser, R.A., Olanow, C.W., Snow, B.J., Freeman, T.B. (1998). Fetal Nigral Transplantation in Parkinson’s Disease. In: Freeman, T.B., Widner, H. (eds) Cell Transplantation for Neurological Disorders. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-476-4_2

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  • DOI: https://doi.org/10.1007/978-1-59259-476-4_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-043-4

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