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Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases

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Cell Transplantation for Neurological Disorders

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

The combination of somatic gene transfer with cell transplantation techniques defines an intriguing new therapeutic concept for the treatment of neurodegenerative diseases. The application of this hybrid technique is made possible by recent developments in several areas of biomedical research. Progress in molecular biology has led to the identification of an increasing number of genes involved in human disease. Developments in cell biology allow researchers to expand and engineer cells in culture more efficiently and methods of neural transplantation are being refined to achieve better graft placement and survival. The application of this so-called ex vivo gene therapy approach to diseases of the central nervous system (CNS) is complicated by the anatomical and functional complexity of the brain as well as the difficulty of accessing dysfunctional areas. Nevertheless, this approach has a great potential for the treatment of neurodegenerative diseases because current treatments are inadequate or not available. This chapter will focus on the development of somatic gene transfer and cell transplantation strategies for Parkinson’s disease (PD) but many of the principles outlined here are also applicable to other neurodegenerative diseases.

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  1. Silke Thode
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  2. Heather K. Raymon
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  3. Fred H. Gage
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Editors and Affiliations

  1. Division of Neurosurgery, Department of Pharmacology and Experimental Therapeutics, The Neuroscience Program, University of South Florida, Tampa, FL, USA

    Thomas B. Freeman MD

  2. Departments of Clinical Neurosciences and Physiology and Neuroscience, Wallenberg Neuroscience Center, Lund University, Lund, Sweden

    HĂĄkan Widner MD, PhD

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Thode, S., Raymon, H.K., Gage, F.H. (1998). Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases. In: Freeman, T.B., Widner, H. (eds) Cell Transplantation for Neurological Disorders. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-476-4_15

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