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Therapeutic Potential of Leukocyte Antiadhesion Strategies in CNS Ischemia

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Neuroprotective Signal Transduction

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Leukocyte appearance in central nervous system (CNS) ischemic tissue has previously been considered to represent a pathophysiological response to existing injury. Recent evidence suggests that leukocytes may also be directly involved in the pathogenesis and extension of CNS ischemia/reperfusion (I/R) injury (Engler et al., 1986; Schmid-Schonbein and Engler, 1986). Two proposed mechanisms of leukocyte involvement in IIR are: direct microvascular occlusion after endothelial and basement membrane adhesion (Schmid-Schonbein, 1987; Mori et al., 1992); and transendothelial migration, with secondary CNS tissue infiltration and neuronal cytotoxic injury (Fassbender et al., 1995). Initial adhesion of leukocytes to microvascular endothelium is essential for initiation of either of these mechanisms (see Fig. lA).

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Authors
  1. Wayne M. Clark
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  2. Justin A. Zivin
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Editors and Affiliations

  1. University of Kentucky, Lexington, KY, USA

    Mark P. Mattson

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Clark, W.M., Zivin, J.A. (1998). Therapeutic Potential of Leukocyte Antiadhesion Strategies in CNS Ischemia. In: Mattson, M.P. (eds) Neuroprotective Signal Transduction. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-475-7_15

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  • DOI: https://doi.org/10.1007/978-1-59259-475-7_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5968-6

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