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Neuroprotective Strategies Based on Interleukin Signaling

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Neuroprotective Signal Transduction

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Cytokines are soluble polypeptide mediators that control the growth, differentiation, and function of most cell types and play a particular role as mediators of inflammation. Cytokines form a network of interactive signals, some of which are stimulatory and others inhibitory. The physiologic roles of cytokines concern the coordination of processes between different cell types and the response to environmental stresses (Dinarello, 1996). With respect to the central nervous system (CNS), cytokines play a specific role and are particularly important in embryonic development, fever, neuroendocrine activation, and changes in behavior and mood. Furthermore, cytokines have been shown to be involved in numerous CNS disorders, such as cerebral ischemia, head trauma, apoptosis, regulation of the immune response to foreign antigens (HIV), and the development of cellular and humoral immunity and inflammatory responses (multiple sclerosis) (Rothwell and Hopkins, 1995). Thus, in the CNS, cytokines play a role in normal physiologic control, as well as being implicated in the pathogenesis of a number of neurologic diseases.

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Authors
  1. David Martin
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  2. Gerald Miller
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  3. Norman Fischer
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Editors and Affiliations

  1. University of Kentucky, Lexington, KY, USA

    Mark P. Mattson

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Martin, D., Miller, G., Fischer, N. (1998). Neuroprotective Strategies Based on Interleukin Signaling. In: Mattson, M.P. (eds) Neuroprotective Signal Transduction. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-475-7_10

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  • DOI: https://doi.org/10.1007/978-1-59259-475-7_10

  • Publisher Name: Humana Press, Totowa, NJ

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