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Antidepressants pp 195–212Cite as

Antidepressants: Beyond the Synapse

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

In this chapter, we discuss the actions of antidepressants in the context of central nervous system (CNS) plasticity. The term “plasticity” implies that the CNS can adapt to conditions that threaten the physical and psychic/emotional well-being of the organism by altering programs of gene expression in specific neuronal and glial cell populations (1–3). These changes affect the construction and pruning of synaptic connections, the concentrations of enzymes and ion channel proteins, the rates of synthesis, release, and degradation of neurotransmitters and neuromodulators, and the densities and activities of their receptors. Ultimately, changes in programs of gene expression determine the intensities of incoming signals, the sensitivities of neuronal systems to those signals, and the nature, amplitude, and duration of CNS responses.

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Authors
  1. S. Paul Rossby
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  2. Fridolin Sulser
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  1. Laboratory of Neuroscience, National Institutes of Health, Bethesda, MD, USA

    Phil Skolnick

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Rossby, S.P., Sulser, F. (1997). Antidepressants: Beyond the Synapse . In: Skolnick, P. (eds) Antidepressants. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-474-0_11

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  • DOI: https://doi.org/10.1007/978-1-59259-474-0_11

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