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β-amyloid-Derived Free Radical Oxidation

A Fundamental Process in Alzheimer’s Disease
  • D. Allan Butterfield
  • Kenneth Hensley
  • Nathan Hall
  • Ramachandran Subramaniam
  • Beverly J. Howard
  • Pamela Cole
  • Servet Yatin
  • Michael LaFontaine
  • Marni E. Harris
  • Marina Aksenova
  • Michael Aksenov
  • John M. Carney
Part of the Contemporary Neuroscience book series (CNEURO)

Abstract

Alzheimer’s disease (AD) research has progressed greatly since the first description of AD by Alzheimer (1) very early in this century. Three pathological hallmarks of AD are:
  1. 1.

    The presence in certain brain regions of senile plaques (SP), entities composed of aggregated β-amyloid surrounded by dystrophic neurites and other moieties;

     
  2. 2.

    Neurofibrillary tangles (NFT), primarily composed of phosphorylated τ, a cytoskeletal protein, and other moieties; and

     
  3. 3.

    Loss of synapses (2–4).

     

Keywords

Electron Paramagnetic Resonance Electron Paramagnetic Resonance Spectrum Protein Oxidation Spin Label Senile Plaque 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • D. Allan Butterfield
  • Kenneth Hensley
  • Nathan Hall
  • Ramachandran Subramaniam
  • Beverly J. Howard
  • Pamela Cole
  • Servet Yatin
  • Michael LaFontaine
  • Marni E. Harris
  • Marina Aksenova
  • Michael Aksenov
  • John M. Carney

There are no affiliations available

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