Abstract
Recent developments in transgenic mice expressing Alzheimer amyloid precursor proteins (APP) have provided a powerful new means for testing hypotheses about the biology and molecular pathogenesis of Alzheimer’s disease (AD). This chapter will delineate some key features of experimental design that are known to influence trans-genic phenotypes. Knowledgeable application of these parameters in experimental design and interpretation may facilitate the production of reproducible and reliable results. The use of these parameters in designing experiments to test hypotheses about the pathogenesis of AD will be illustrated.
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Hsiao, K.K. (1997). Understanding the Biology and Molecular Pathogenesis of Alzheimer’s Disease in Transgenic Mice Expressing Amyloid Precursor Proteins. In: Wasco, W., Tanzi, R.E. (eds) Molecular Mechanisms of Dementia. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-471-9_3
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DOI: https://doi.org/10.1007/978-1-59259-471-9_3
Publisher Name: Humana Press, Totowa, NJ
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