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Potential Biological Mechanisms of ApoE in Alzheimer’s Disease

  • G. William Rebeck
Part of the Contemporary Neuroscience book series (CNEURO)

Abstract

Other chapters in this book discuss the three genes involved in the development of early onset forms of AD: APP, presenilin-1, and presenilin-2. These genes share a number of features. First, mutations in these genes lead to early onset-forms of AD. Second, mutations in these genes invariably lead to AD; i.e., they are completely penetrant. Third, the functions of the APP, presenilin-1, and presenilin-2 gene products are unknown. In order to determine the functions of these genes, considerable research is being invested in examining the distribution of these proteins, the regulation of their expression, and the identification of proteins that interact with them.

Keywords

Neurite Outgrowth ApoE Genotype Human Apolipoprotein Macrophage Scavenger Receptor ApoE Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1997

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  • G. William Rebeck

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