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Inflammatory Mediators in Alzheimer’s Disease

  • Chapter
Molecular Mechanisms of Dementia

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

In 1984, when our laboratory first began conducting research on inflammation and Alzheimer’s disease (AD) (1), the brain was still widely considered to be immunologically privileged (reviewed in ref 2). Now, a virtual textbook of inflammatory mediators have been shown to be present in the central nervous system (CNS) or expressed by CNS cells in culture (Table 1). Most of these molecules are known to be increased in expression in AD limbic and neocortex compared to similar samples from nondemented elderly (ND) patients. By understanding the functions of inflammatory mediators in general, and their interactions with AD pathology in particular, a better appreciation of their pathogenic potential may be fostered.

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  1. Joseph Rogers
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  2. Stephen O’Barr
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  1. Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Wilma Wasco  & Rudolph E. Tanzi  & 

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Rogers, J., O’Barr, S. (1997). Inflammatory Mediators in Alzheimer’s Disease. In: Wasco, W., Tanzi, R.E. (eds) Molecular Mechanisms of Dementia. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-471-9_11

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