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Role of Axonal and Somatodendritic Monoamine Transporters in Action of Uptake Blockers

  • Chapter
Neurotransmitter Transporters

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

There is a large body of evidence indicating the presence of neuronal monoamine transport systems for dopamine (DA), norepinephrine (NE), and serotonin (5-HT) not only in axon terminals, but also in somatodendrites (6,38,44,61,67,82,100).Monoamine transporters are central to the actions of uptake blockers such as antidepressants and psychostimulants. This chapter focusses on recent findings obtained from in vitro and in vivo studies with uptake blockers at the level of both somatodendritic and axonal monoamine transporters, with particular attention to our findings on the monoamine effects of various uptake blockers in the axonal and somatodendritic areas of the DA pathway. These findings have provided new insights into the roles of both axonal and somatodendritic monoamine transporters in determining the potency, the selectivity, and the regulation of the action of uptake blockers. Further elucidation of these roles may assist in understanding the complex mechanisms responsible for various neuropathophysiological conditions, for the therapeutics of antidepressants, and for the reinforcement by abused drugs such as cocaine.

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Authors
  1. Nian-Hang Chen
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  2. Maarten E. A. Reith
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  1. College of Medicine, University of Illinois, Peoria, IL, USA

    Maarten E. A. Reith

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Chen, NH., Reith, M.E.A. (1997). Role of Axonal and Somatodendritic Monoamine Transporters in Action of Uptake Blockers. In: Reith, M.E.A. (eds) Neurotransmitter Transporters. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-470-2_12

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  • DOI: https://doi.org/10.1007/978-1-59259-470-2_12

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