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Neuroprotective Strategies for Treatment of Acute Ischemic Stroke

  • Chapter
Neurotherapeutics

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Stroke is an abrupt onset of neurological deficits caused by generalized or localized cerebral blood flow reduction (ischemia). The ischemia occurs after hemorrhage or after blood vessel occlusion by emboli or stenosis. Stroke is a major cause of death and disability with no proven treatment. In the United States, the annual rate is about 1–2 incidents per 1000 persons (Barnett, 1985). Although in recent years the rate of mortality has declined, in the United States, about 15% of hospitalized strokes result in death (Howard et al., 1991). Even transient ischemic events may merit treatment. Neurological deficits lasting < 24 h are termed transient ischemic attacks (TIAs). The distinction between a TIA and a stroke may blur as improved diagnostic techniques find damage from TIAs.

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Pullan, L.M. (1996). Neuroprotective Strategies for Treatment of Acute Ischemic Stroke. In: Pullan, L.M., Patel, J. (eds) Neurotherapeutics. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-466-5_7

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