Abstract
Epilepsy, a condition of recurrent, paroxysmal seizures, is a major, worldwide, health problem. The epileptic seizure represents an abnormal synchronized discharge among a large population of central neurons. Although the cause of this synchronized activity is largely a mystery, the occurrence of seizures in an epileptic patient can be diminished or eliminated by drugs that target the basic excitability mechanisms of neurons. Most presently used antiepileptic medications were developed by empirical drug screening or serendipity. However, in the past several decades, as understanding of the functional activity of brain circuits has increased, there has been an intense effort to develop new antiepileptic medications on a rational basis. Although progress has been measured, some rationally developed antiepileptic drugs are now entering the market.
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Rogawski, M.A. (1996). Epilepsy. In: Pullan, L.M., Patel, J. (eds) Neurotherapeutics. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-466-5_6
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-4757-5978-5
Online ISBN: 978-1-59259-466-5
eBook Packages: Springer Book Archive