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Neurotransmitters and Epilepsy pp 161–190Cite as

In Vitro Models of Epilepsy

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

In this chapter, we shall review what is known about the cellular mechanisms of epileptic events in vitro. Our main concern is to understand the electrical events that neurons generate during a fit, and to understand what kinds of interactions (synaptic and nonsynaptic) between neurons underlie the fit. We further seek to comprehend which intrinsic properties of neurons are required for epilepsy or that at least facilitate epileptogenesis. Our method consists of making experimental observations of seizure phenomena in the hippocampal slice, attempting to reproduce the observations with simulation models on a large computer, and testing the models with further experiments. We shall emphasize underlying mechanisms that are as independent as possible of physiological and pharmacological details. This provides a clear conceptual framework in which to interpret diverse experiments. Such an approach is necessary because epilepsy involves understanding the behavior of a population of neurons. Our work has lead to models that illuminate the underlying mechanisms of two types of epileptic events: interictal spikes and tonic seizures.

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Authors
  1. Roger D. Traub
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  2. Robert K. S. Wong
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  3. Richard Miles
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Editor information

Editors and Affiliations

  1. Department of Basic Sciences, College of Medicine at Peoria, University of Illinois, Peoria, Illinois, USA

    Phillip C. Jobe

  2. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA

    Hugh E. Laird II

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Traub, R.D., Wong, R.K.S., Miles, R. (1987). In Vitro Models of Epilepsy. In: Jobe, P.C., Laird, H.E. (eds) Neurotransmitters and Epilepsy. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-462-7_7

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  • DOI: https://doi.org/10.1007/978-1-59259-462-7_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5982-2

  • Online ISBN: 978-1-59259-462-7

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