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Cadmium Toxicity and Neural Cell Damage

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Neurobiology of the Trace Elements

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Cadmium was discovered in 1817 by the German investigator Friedrich Stromeier.124 The name cadmium was taken from the ancient Greek word for zinc oxide.8 Toxic effects of cadmium in mammals were reported as early as 1858 by Sovet109 and 1867 by Marmé.76,91 An extensive literature has now accumulated on the adverse effects of cadmium on various tissues in man and animals (see reviews by Friberg et a1.,33,34 Fassett,23,24, Fleischer et al.,27 Samarawickrama98) .

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References

  1. Adams, R.G. and Crabtree, N. (1961) Anosmia in alkaline battery workers, J. Industr. Med. 18, 216–221.

    Google Scholar 

  2. Aoki, A. and Hoffer, A.P. (1978) Reexamination of the lesions in rat testis caused by cadmium. Biol. Reprod. 18, 579–591.

    Google Scholar 

  3. Aronstam, R.S., Abood, L.G. and Hoss, W. (1978) Influence of sulfhydryl reagents and heavy metals on the functional state of the muscarinic acetylcholine receptor in rat brain. Molec. Pharmacol. 14, 575–586.

    Google Scholar 

  4. Arvidson, B. (1979) Distribution of intravenously injected protein tracers in peripheral ganglia of adult mice. Exp. Neurol. 63, 388–410.

    Article  PubMed  CAS  Google Scholar 

  5. Arvidson, B. (1980) Regional differences in severity of cadmium induced lesions in the peripheral nervous system in mice. Acta Neuropathol. 49, 213–224.

    Article  PubMed  CAS  Google Scholar 

  6. Arvidson, B. (1981) Is cadmium toxic to the nervous system? Trends Neurosci. 4, 11–13.

    Google Scholar 

  7. Arvidson, B. and Tjälve, H. (1983) Distribution of 109Cd in the nervous system of rats after intravenous injection. Neurotoxicol. Neurobiol. in press.

    Google Scholar 

  8. Aylett, B.J. (1979) The chemistry and bioinorganic chemistry of cadmium. In: M. Webb (Ed.), The Chemistry, Biochemistry and Biology of Cadmium, Elsevier, Amsterdam, pp. 1–44.

    Google Scholar 

  9. Baader, E.W. (1952) Chronic cadmium poisoning. Ind. Med. Surg. 21, 427–430.

    PubMed  CAS  Google Scholar 

  10. Berlin, M. and Ullberg, S. (1963) The fate of 109Cd in the mouse. Arch. Environm. Health 7, 686–693.

    Google Scholar 

  11. Betz. AL., Firth, JA. and Goldstein, G.W. (1980) Polarity of the bloodbrain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells. Brain Res. 192, 17–28.

    Article  Google Scholar 

  12. Björklund, H., Hoffer, B., Olson, L. and Seiger, A. (1981) Differential morphological changes in sympathetic nerve fibers elicited by lead, cadmium and mercury. Environm. Res. 26, 69–80.

    Article  Google Scholar 

  13. Buhler, D.R., Wright, D.C., Smith, K.L. and Tinsley, IJ. (1981) Cadmium absorption and tissue distribution in rats provided low concentrations of cadmium in food or drinking water. J. Toxicol. Environm. Health 8, 185–197.

    Article  CAS  Google Scholar 

  14. Carrol, R.E. (1966) The relationship of cadmium in the air to cardiovascular disease death rates. J. Amer. Med. Assn. 198, 267–270.

    Google Scholar 

  15. Clasen, AA., Hartman, J.J., Starr, A.J., Coogan, P.S., Pandolfi, S., Laing, I., Becker, R. and Hass, G.M. (1974) Electron microscopic and chemical studies of lead encephalopathy: a comparative study of the human and experimental disease. Am. J. Pathol. 74, 215–233.

    PubMed  CAS  Google Scholar 

  16. Cole, G.M. and Baer, L.S. (1944) Food poisoning from cadmium. Nav. Med. Bull. 43, 398–403.

    Google Scholar 

  17. Cooper, G.P. and Steinberg, O. (1977) Effects of cadmium and lead on adrenergic neuromuscular transmission in the rabbit. Am. J. Physiol. 232, C128–C131.

    Google Scholar 

  18. Cooper, G.P., Kober, T.E. and Manalis, R.S. (1980) Differences in the effects of cadmium and lead on synaptic transmission. Soc. Neurosci. Abstr. 6, 176.

    Google Scholar 

  19. Cooper, G.P., Fox, DA., Howell, W.E., Laurie, R.D., Tsang, W. and Lewkowski, J.P. (1980) Visual evoked responses in rats exposed to heavy metals. In: W.H. Merigan and B. Weiss (Eds.), Neurotoxicity of the Visual System, Raven Press, New York, pp. 203–218.

    Google Scholar 

  20. Davis, J.S., Flynn, F.V. and Platt, H.S. (1968) The characterization of urine protein by gel filtration. Clin. Chim. Acta 21, 357–362.

    Article  PubMed  CAS  Google Scholar 

  21. Decker, C.F., Byerrum, R.U. and Hoppert, CA. (1957) A study of the distribution and retention of cadmium-115 in the albino rat. Arch. Biochem. 66, 140–144.

    Article  PubMed  CAS  Google Scholar 

  22. Ewers, U. and Erbe, R. (1980) Effects of lead, cadmium and mercury on brain adenylate cyclase. Toxicol. 16, 227–237.

    Article  Google Scholar 

  23. Fassett, D.W. (1972) Cadmium. In: D.H.K. Lee (Ed.), Metallic Contaminants and Human Health, Academic Press, New York, pp. 97–126.

    Google Scholar 

  24. Fassett, D.W. (1975) Cadmium: Biological effects and occurrence in the environment. Ann. Rev. Pharmacol. 15, 425–435.

    Article  PubMed  CAS  Google Scholar 

  25. Ferm, V.H. and Carpenter, SJ. (1968) The relationship of cadmium and zinc in experimental mammalian teratogenesis. Lab. Invest. 18, 429–432.

    PubMed  CAS  Google Scholar 

  26. Flanagan, P.R., McLellan, J.S., Haist, J., Cherian, M.G., Chemberlain, MJ. and Valberg, L.S. (1978) Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterol. 74, 841–846.

    CAS  Google Scholar 

  27. Fleischer, M., Sarofim, A.F., Fassett, D.W., Hammond, P., Shacklette, H.T., Nisbet, I.C.T. and Epstein, S. (1974) Environmental impact of cadmium: A review by the panel on hazardous trace substances. Environm. Health Persp. 7, 253–323.

    Article  Google Scholar 

  28. Forshaw, PJ. (1977) The inhibitory effect of cadmium on neuromuscular transmission in the rat. Eur. J. Pharmacol. 42, 371–377.

    Article  PubMed  CAS  Google Scholar 

  29. Foster, C.L. and Cameron, E. (1963) Observations on the histological effects of sub-lethal doses of cadmium chloride in the rabbit. II. The effect on the kidney cortex. J. Anat. 97, 281–285.

    PubMed  CAS  Google Scholar 

  30. Friberg, L. (1948) Proteinuria and emphysema among workers exposed to cadmium and nickel dust in a storage battery plant. Proc. Int. Congr. Ind. Med. 9, 641–645.

    Google Scholar 

  31. Friberg, L. (1950) Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning. Acta Med. Scand. 138, Suppl 240.

    Google Scholar 

  32. Friberg, L. (1957) Deposition and distribution of cadmium in man in chronic poisoning Arch. Ind. Health 16, 27–29.

    CAS  Google Scholar 

  33. Friberg, L., Piscator, M., Nordberg, G.F. and Kjellström, T. (1974) Cadmium in the Environment. CRC Press Inc., Cleveland.

    Google Scholar 

  34. Friberg, L., Kjellström, T., Nordberg, G.F. and Piscator, M. (1979) Cadmium. In: L. Friberg, G.F. Nordberg, and V.B. Vouk (Eds.), Handbook on the Toxicology ofMetals, Elsevier, Amsterdam, pp. 355–382.

    Google Scholar 

  35. Gabbiani, G. (1966) Action of cadmium chloride on sensory ganglia. Experientia 22, 261–262.

    Article  PubMed  CAS  Google Scholar 

  36. Gabbiani, G. (1969) Endothelial microvilli in the vessels of the rat gasserian ganglion and testis. Z. Zellforsch. 97, 111–117.

    Article  PubMed  CAS  Google Scholar 

  37. Gabbiani, G., Baic, D. and Déziel, C. (1967) Toxicity of cadmium for the central nervous system. Exp. Neurol. 18, 154–160.

    Article  PubMed  Google Scholar 

  38. Gabbiani, G., Baic, D. and Déziel, C. (1967) Studies on tolerance and ionic antagonism for cadmium and mercury. Can. J. Physiol. Pharmacol. 45, 443–450.

    Article  Google Scholar 

  39. Gabbiani, G., Gregory, A. and Baic, D. (1967) Cadmium-induced selective lesions of sensory ganglia. J. Neuropath. Exp. Neurol. 26, 498–506.

    Article  PubMed  Google Scholar 

  40. Gabbiani, G., Badonnel, M.-C., Mathewson, S.M. and Ryan, G.B. (1974) Acute cadmium intoxication. Early selective lesions of endothelial clefts. Lab. Invest. 30, 686–695.

    PubMed  Google Scholar 

  41. Girod, C. and Dubois, M.P. (1976) Influence du chlorure de cadmium sur l’axe hypophyso-testiculaire du hamster doré. Ann. Endocrinol. (Paris) 37, 273–274.

    Google Scholar 

  42. Goldstein, G.W., Asbury, A.K. and Diamond, I. (1974) Pathogenesis of lead encepthalopathy-uptake of lead and reaction of brain capillaries. Arch. Neurol. 31, 382–389.

    Article  PubMed  CAS  Google Scholar 

  43. Gunn, SA., Gould, T.C. and Anderson, WAD. (1963) Cadmiuminduced interstitial cell tumours in rats and mice and their prevention by zinc. J. Nat. Cancer Inst. 31, 745–749.

    PubMed  CAS  Google Scholar 

  44. Gunn, SA., Gould, T.C. and Anderson, WA.D. (1967) Specific response of mesenchymal tissue to cancerogenesis by cadmium. Arch. Pathol. 83, 493–496.

    PubMed  CAS  Google Scholar 

  45. Haddow, A., Dukes, C.E. and Mitchley, B.C.V. (1961) Carcinogeneity of iron preparations and metal-carbohydrate complexes. Rep. Br. Emp. Cancer Campn. 39, 74–78.

    Google Scholar 

  46. Haddow, A., Roe, F.J.C., Dukes, C.E. and Mitchley, B.C.V. (1964) Cadmium neoplasia: Sarcomata of the site of injection of cadmium sulphate in rats and mice. Br. J. Cancer 18, 667–673.

    Article  PubMed  Google Scholar 

  47. Hagino, N. (1957) About investigations on Itai-itai disease. J. Toyama Med. Assoc. Suppl., Dec. 21.

    Google Scholar 

  48. Hagino, N. (1973) Itai-itai disease and vitamin D. Dig. Sci. Labour 28, 32–36.

    Google Scholar 

  49. Hamada, T., Iwamasa, T., Tsuru, T., Sato, K. and Takeuchi, T. (1980) Mechanism of glycogenosome formation in axons of cadmiuminduced neuropathy. Ultrastructural and biochemical studies. Neurotoxicol. 2, 33–41.

    Google Scholar 

  50. Harrison, J.F., Lunt, G.S., Scott, P. and Blainey, J.D. (1968) Urinary lysozyme, ribonuclease and low-molecular weight protein in renal disease. Lancet1, 371–380.

    Article  PubMed  CAS  Google Scholar 

  51. Hastings, F., Choudhury, H., Petering, H.G. and Cooper, G.P. (1978) Behavioral and biochemical effects of low-level prenatal cadmium exposure in rats. Bull. Environ. Contam. Toxicol. 20, 96–101.

    Article  PubMed  Google Scholar 

  52. Hayashi, H. and Takayama, K. (1978) Inhibitory effects of cadmium on the release of acetylcholine from cardiac nerve terminals. Jap. J. Physiol. 28, 333–345.

    Article  Google Scholar 

  53. Hedlund, B., Gamarra, M. and Bartfai, T. (1979) Inhibition of striatal muscarinic receptors in vivo by cadmium. Brain Res. 168, 216–218.

    Article  PubMed  Google Scholar 

  54. Hoffman, E.O., Cook, JA., DiLuzio, N.R. and Coover, JA. (1975) The effects of acute cadmium administration in the liver and kidney of the rat. Light and electron microscopic studies. Lab. Invest. 32, 655–673.

    Google Scholar 

  55. Hrdina, PD., Peters, DA.V. and Singhal, R.L. (1976) Effects of chronic exposure to cadmium, lead and mercury on brain biogenic amines in the rat. Res. Comm. Chem. Pathol. Pharmacol. 15, 483–493.

    CAS  Google Scholar 

  56. Ishizaki, A., Fukushima, M. and Sakamoto, M. (1970) Distribution of Cd in biological materials. II. Cadmium and zinc contents of foodstuffs. Jap. J. Hyg. 25, 207–211.

    Article  PubMed  Google Scholar 

  57. Jacobs, J.M. (1977) Penetration of systemically injected horseradish peroxidase into ganglia and nerves of the autonomic nervous system. J. Neurocytol. 6, 607–618.

    Article  PubMed  CAS  Google Scholar 

  58. Jacobs, J.M., MacFarlane, R.M. and Cavanagh, J.B. (1976) Vascular leakage in the dorsal root ganglia of the rat, studied with horseradish peroxidase. J. Neurol. Sci. 29, 95–107.

    Article  PubMed  CAS  Google Scholar 

  59. Johanson, C.E. (1980) Permeability and vascularity of the developing brain: cerebellum vs cerebral cortex. Brain Res. 190, 3–16.

    Article  PubMed  CAS  Google Scholar 

  60. Kagi, J.H.R. and Vallee, B.L. (1960) Metallothionein: a cadmium and zinc-containing protein from equine renal cortex. J. Biol. Chem. 235, 3460–3465.

    PubMed  CAS  Google Scholar 

  61. Kasuya, M., Sugawara, N. and Okada, A. (1974) Toxic effect of cadmium stearate on rat cerebellum in culture. Bull. Environ. Contam. Toxicol. 12, 535–540.

    Article  PubMed  Google Scholar 

  62. Kawai, K., Fukuda, K. and Kimura, M. (1976) In: Effects and Dose-Response Relationships of Toxic Metals. G.F. Nordberg (Ed.), Elsevier, Amsterdam, pp. 343–370.

    Google Scholar 

  63. Kipling, M.D. and Waterhouse JA.H. (1967) Cadmium and prostatic carcinoma. Lancet 1, 730–733.

    Article  Google Scholar 

  64. Kjellström, T., Friberg, L. and Rahnster, B. (1979) Mortality and cancer morbidity among cadmium-exposed workers. Environ. Health. Persp. 28, 199–205.

    Google Scholar 

  65. Lai, J.C.K., Guest, J.F., Lim, L. and Davison, A.N. (1978) The effects of transition-metal ions on rat brain synaptosomal amine-uptake systems. Biochem. Soc. Trans. 6, 1010–1012.

    PubMed  CAS  Google Scholar 

  66. Lai, J.C.K., Guest, J.F., Leung, T.K.C., Lim, L. and Davison, A.N. (1980) The effects of cadmium, manganese and aluminum on sodiumpotassium-activated and magnesium-activated adenosine triphosphatase activity and choline uptake in rat brain synaptosomes. Biochem. Pharmacol. 29, 141–146.

    Article  PubMed  CAS  Google Scholar 

  67. Lane, R.E. and Campbell, A.C.P. (1954) Fatal emphysema in two men making a copper cadmium alloy, Brit. J. Industr. Med.11, 118–122.

    PubMed  CAS  Google Scholar 

  68. Larsson, S.-E, and Piscator, M. (1971) Effect of cadmium on skeletal tissue in normal and calcium-deficient rats Isr. J. Med. Sci. 7, 495–502.

    PubMed  CAS  Google Scholar 

  69. Lauwerys, R. (1979) Cadmium in man. In: M. Webb (Ed.) The Chemistry, Biochemistry and Biology of Cadmium, Elsevier, Amsterdam, pp. 449–452.

    Google Scholar 

  70. Lemen, RA., Lee, J.S., Wagoner, J.K. and Blejer, H.P. (1976) Cancer mortality among cadmium production workers. Ann. NYAcad. Sci. 271, 273–276.

    Article  CAS  Google Scholar 

  71. Lewis, G.P., Jusko, W.J. and Coughlin, L.L. (1972) Cadmium accumulation in man: influence of smoking, occupation, alcoholic habit, and disease. J. Chronic Dis. 25, 717–723.

    Article  PubMed  CAS  Google Scholar 

  72. Lucis, OJ., Lucis, R. and Shaikh, ZA. (1972) Cadmium and zinc in pregnancy and lactation. Arch. Environ. Health. 25, 14–22.

    PubMed  CAS  Google Scholar 

  73. Lucis, OJ., Lynk, M.E. and Lucis, R. (1969) Turnover of cadmium 109 in rats. Arch. Environ. Health 18, 307–312.

    PubMed  CAS  Google Scholar 

  74. Magour, S., Cumpelik, O. and Paulus, M. (1979) Effect of cadmium and copper on monoamine oxidase type A and B in brain liver mitochondria. J. Clin. Chem. Clin. Biochem. 17, 777–780.

    PubMed  Google Scholar 

  75. Margoshes, M. and Vallee, B.C. (1957) A cadmium protein from equine kidney cortex. J. Am. Chem. Soc. 79, 4813–4814.

    Article  Google Scholar 

  76. Marmé, W. (1867) Über die giftige Wirkung und den Nachweis einiger Cadmium-Verbladungen. Ztschr. Rationel. Med. 29, 125–130.

    Google Scholar 

  77. Moritsugi, M. and Kobayashi, J. (1964) Study on trace metals in biomaterials. II. Cadmium content in polished rice. Ber. Ohara Inst. Landwirtsch. Biol. Okayama Univ. 12, 145–149.

    Google Scholar 

  78. Nordberg, G.F. (1972) Cadmium metabolism and toxicity. Environ. Physiol. Biochem. 2, 7–36.

    CAS  Google Scholar 

  79. Nordberg, G.F. and Nishiyama, K. (1972) Whole-body and hair retention of cadmium in mice. Arch. Environ. Health 24, 209–214.

    Google Scholar 

  80. Nordberg, M. and Nordberg, G.F. (1975) Distribution of metallothionein-bound cadmium and cadmium chloride in mice: preliminary studies. Environ. Health Persp. 12, 103–108.

    Article  CAS  Google Scholar 

  81. Olsson, Y. (1971) Studies on vascular permeability in peripheral nerves. IV. Distribution of intravenously injected protein tracers in the peripheral nervous system of various species. Acta Neuropathol. 16, 103–116.

    Article  Google Scholar 

  82. Parizek, J. (1956) Effect of cadmium salts on testicular tissue. Nature177, 1036–1037.

    PubMed  CAS  Google Scholar 

  83. Parizek, J. (1957) The destructuve effect of cadmium on testicular tissue and its prevention by zinc. J. Endocrinol. 15, 56–59.

    Article  PubMed  CAS  Google Scholar 

  84. Paterson, J.C. (1947) Studies on the toxicity of inhaled cadmium. III. The pathology of cadmium smoke poisoning in man and in experimental animals. J. Ind. Hyg. Toxicol. 29, 294–302.

    PubMed  CAS  Google Scholar 

  85. Pentschew, A. and Garro, F. (1966) Lead encephalo-myelopathy of the suckling rat and its implications on the porphyrinopathic nervous system. Acta Neuropathol. 6, 266–278.

    Article  PubMed  Google Scholar 

  86. Perry, H.M. and Erlanger, M.W. (1971) Hypertension and tissue metal levels after intraperitoneal cadmium, mercury, and zinc. Am. J. Physiol. 220, 808–811.

    PubMed  CAS  Google Scholar 

  87. Pham-Huu-Chanh and Plancade, Y. (1971) Etude comparée des effets du zinc et du cadmium sur les activites cholinesterasiques tissulaires du rat. Biochem. Pharmacol. 20, 729–736.

    Article  Google Scholar 

  88. Piscator, M. (1981) Role of cadmium in carcinogenesis with special reference to cancer of the prostate. Environ. Health Persp. 40, 107–120.

    Article  CAS  Google Scholar 

  89. Potts, C.L. (1965) Cadmium proteinuria-the health of battery workers exposed to cadmium oxide dust. Ann. Occup. Hyg. 8, 55–62.

    Article  PubMed  CAS  Google Scholar 

  90. Pringle, B.H., Hissong, D.E., Katz, E.L. and Mulawka, S.T. (1968) Trace metal accumulation by estuarine mollusks. J. Sanit. Eng. Div. Proc. Am. Soc. Civ. Eng. 94, 455–463.

    CAS  Google Scholar 

  91. Prodan, L. (1932) Cadmium poisoning: I. The history of cadmium poisoning and uses of cadmium. J. Ind. Hyg. 14, 132–155.

    CAS  Google Scholar 

  92. Rahola, T., Aaran, R.-K. and Miettinen, J.K. (1971) Half-time studies of mercury and cadmium by whole body counting. IAEA Symposium on the Assessment of Radioactive Contamination in Man, IAEA, Vienna.

    Google Scholar 

  93. Rastogi, R.B., Merali, Z. and Singhal, R.L. (1977) Cadmium alters behaviour and the biosynthetic capacity for cathecolamines and serotonin in neonatal rat brain. J. Neurochem. 28, 789–794.

    Article  PubMed  CAS  Google Scholar 

  94. Reynolds, C.V. and Reynolds, E.B. (1971) Cadmium in crabs and crabmeat. J. Assoc. Public Anal. 9, 112–115.

    CAS  Google Scholar 

  95. Ribas-Ozonas, B., Ochoa Estomba, M.C. and Santos-Ruiz, A. (1974) Activation of serotonin and 5-hydroxyindolacetic acid in brain structures after application of cadmium. In: W.G. Hoekstra, J.W. Suttie, H.E. Ganther and W. Mertz (Eds.) International Symposium on Trace Element Metabolism in Animals-2, University Park press, Baltimore, pp. 476–478.

    Google Scholar 

  96. Rohrer, S.R., Shaw, S.M. and Lamar, C.H. (1978) Cadmium induced endothelial cell alteration in the fetal brain from prenatal exposure. Acta Neuropath. 44, 147–149.

    Article  PubMed  CAS  Google Scholar 

  97. Romanul, F.C., Bannister, R.G. (1962) Localized areas of high alkaline phosphatase activity in endothelium of arteries. Nature 195, 611–612.

    Article  PubMed  CAS  Google Scholar 

  98. Samarawickrama, G.P. (1979) Biological effects of cadmium in mammals. In: M. Webb (Ed.) The Chemistry, Biochemistry and Biology of Cadmium. Elsevier, Amsterdam, pp. 341–422.

    Google Scholar 

  99. Sato, K., Iwamasa, T., Tsuru, T. and Takeuchi, T. (1978) An ultrastructural study of chronic cadmium-induced neuropathy. Acta Neuropathol. 41, 185–190.

    Article  PubMed  Google Scholar 

  100. Schlaepfer, W.W. (1971) Sequential study of endothelial changes in acute cadmium intoxication. Lab Invest. 25, 556–564.

    PubMed  CAS  Google Scholar 

  101. Schnell, R.C., Prosser, T.D. and Miya, T.S. (1974) Cadmium-induced potentiation of hexobarbital sleep time in rats. Experientia 30, 528–529.

    Article  PubMed  CAS  Google Scholar 

  102. Schroeder, HA. (1964) Cadmium hypertension in rats.Am. J. Physiol. 207, 62–68.

    PubMed  CAS  Google Scholar 

  103. Schroeder, HA. (1965) Cadmium as a factor in hypertension. J. Chronic Dis. 18, 647–653.

    Article  CAS  Google Scholar 

  104. Schroeder, HA. and Mitchener, M. (1971) Toxic effects of trace elements on the reproduction of mice and rats. Arch. Environ. Health 23,102–106.

    Article  PubMed  CAS  Google Scholar 

  105. Schroeder, HA., Nason, A.P. and Balassa, J.J. (1967) Trace metals in rat tissues as influenced by calcium in water. J. Nutr. 93, 331–339.

    PubMed  CAS  Google Scholar 

  106. Sharma, R.P. and Obersteiner, E.J. (1981) Metals and neurotoxic effects: cytotoxicity of selected metallic compounds on chick ganglia cultures. J. Comp. Path. 91, 235–244.

    Article  PubMed  CAS  Google Scholar 

  107. Smith, J.C., Kench, J.E. and Smith, J.P. (1957) Chemical and histological post-mortem studies on a workman exposed for many years to cadmium oxide fume. Brit. J. Industr. Med. 14, 246–249.

    PubMed  CAS  Google Scholar 

  108. Smithells, C.J. (1976) Metals Reference Handbook, 5th ed, Butterworths, London.

    Google Scholar 

  109. Sovet (1858) Empoisonnement par une poudre à ecurer l’argenterie. Presse Med. Belge 10, 69–70.

    Google Scholar 

  110. Suzuki, S., Taguchi, T. and Yokohashi, G. (1969) Dietary factors influencing upon the retention rate of orally administered ll5mmCdCl2 in mice with special reference to calcium and protein concentrations in diet. Ind. Health 7, 155–160.

    Article  Google Scholar 

  111. Szadkowski, D., Schultze, H., Schaller, K.H. and Lehnert, G. (1969) Zur okologischen Bedeutung des Schwermetallgehaltes von Zigaretten. Arch. Hyg. Bakteriol. 153, 1–8.

    PubMed  Google Scholar 

  112. Tischner, K.H. (1980) Cadmium. In: P.S. Spencer and H.H. Schaumburg (Eds.) Experimental and Clinical Neurotoxicology, Williams and Wilkins, Baltimore, pp. 348–355.

    Google Scholar 

  113. Tischner, K.H. and Schröder, J.M. (1972) The effects of cadmium chloride on organotypic cultures of rat sensory ganglia. J. Neurol. Sci. 16, 383–399.

    Article  PubMed  CAS  Google Scholar 

  114. Toda, N. (1973) Influence of cadmium ions on the transmembrane potential and contractility of isolated rabbit left atria. J. Pharmacol. Exp. Therap. 186, 60–66.

    CAS  Google Scholar 

  115. Toda, N. (1976) Neuromuscular blocking action of cadmium and manganese in isolated frog striated muscle. Eur. J. Pharmacol. 40, 67–95.

    Article  PubMed  CAS  Google Scholar 

  116. Todd, A.S. (1964) Some topographical observations on fibrinolysis. J. Clin. Pathol. 17, 324–327.

    Article  PubMed  CAS  Google Scholar 

  117. Vallee, B.L. and Ulmer, D.D. (1972) Biochemical effects of mercury, cadmium and lead. Ann. Rev. Biochem. 41, 91–96.

    Article  PubMed  CAS  Google Scholar 

  118. Vorobjeva, R.S. (1957a) On occupational lung disease in prolonged action of aerosol of cadmium oxide. Arch. Patologii 8, 25–30.

    Google Scholar 

  119. Vorobjeva, R.S. (1975b) Investigations of the nervous system function in workers exposed to cadmium oxide. In. Neuropat. Psikhiat. 57, 385–393.

    Google Scholar 

  120. Walsh, J.J. and Burch, G.E. (1959) The rate of disappearance from plasma and subsequent distribution of radiocadmium (115mmCd) in normal dogs. J. Lab. Clin. Med. 54, 59–65.

    PubMed  CAS  Google Scholar 

  121. Webb, M. (1972) Binding of cadmium ions by rat liver and kidney. Biochem. Pharmacol. 21, 2751–2765.

    Article  PubMed  CAS  Google Scholar 

  122. Webb, M. (1975) Cadmium. Br. Med. Bull. 31, 246–250.

    PubMed  CAS  Google Scholar 

  123. Webster, W.S. and Valois, AA. (1981) The toxic effects of cadmium on the neonatal mouse CNS. J. Neuropath. Exp. Neurol. 40, 247–257.

    Article  PubMed  CAS  Google Scholar 

  124. Weeks, M.E. and Leicester, H.M. (1968) Discovery of the Elements. J. Chem. Ed., Easton, pp. 502–509.

    Google Scholar 

  125. Wisniewska-Knypl, I.M., Jablonska, J. and Myslak, Z. (1971) Binding of cadmium on metallothionein in man: an analysis of a fatal poisoning by cadmium iodide. Arch. Toxikol. 28, 46–53.

    PubMed  CAS  Google Scholar 

  126. Wong, P.C.L. and Lim, L. (1981) The effects of aluminium, manganese and cadmium chloride on the methylation of phospholipids in the rat brain synaptosomal membrane. Biochem. Phamacol. 30, 1704–1705.

    Article  CAS  Google Scholar 

  127. Wong, P.C.L., Lai, J.C.K., Lim, L. and Davison, A.N. (1981) Selective inhibition of L-glutamate and gammaaminobutyrate transport in nerve ending particles by aluminium, manganese and cadmium chloride. J. Inorg. Biochem. 14, 253–260.

    Article  PubMed  CAS  Google Scholar 

  128. Wood, R.W. (1978) Stimulus properties of inhaled substances. Env. Health Persp. 26, 69–76.

    Article  CAS  Google Scholar 

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  1. Neuropathological Laboratory, Department of Pathology, University of Uppsala, Uppsala, Sweden

    Björn Arvidson

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  1. Björn Arvidson
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Ivor E. Dreosti Richard M. Smith

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© 1983 Springer Science+Business Media New York

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Arvidson, B. (1983). Cadmium Toxicity and Neural Cell Damage. In: Dreosti, I.E., Smith, R.M. (eds) Neurobiology of the Trace Elements. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-458-0_2

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  • DOI: https://doi.org/10.1007/978-1-59259-458-0_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5959-4

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