Regulatory Aspects of Neovascularization
Angiogenesis is a critical component of tissue repair and involves a series of interconnected, interdependent events, among which are generation and reception of angiogenic signals, chemotaxis, proteolysis of extracellular matrix, cell replication, cell-matrix adhesion, tube formation, and ligation of the newly formed vascular sprouts. The discovery of angiogenic cytokines and growth factors has greatly contributed to understanding ofthe regulation of angiogenesis (1–3). Although many angiogenic substances have been found that potentially upregulate most of the above mentioned angiogenic events, no unifying postulate for their synthesis or their mode of action has emerged. Perhaps a search for how these substances are elicited may prove to be a fruitful alternative. Only recently have research efforts touched on how the initiation of angiogenesis could be linked to the metabolic state (4).
KeywordsVascular Endothelial Growth Factor Angiogenic Activity Vascular Endothelial Growth Factor Gene Prolyl Hydroxylase Vascular Endothelial Growth Factor Release
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