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Fibroblast Growth Factors in Tumor Progression and Angiogenesis

  • Israel Vlodavsky
  • Gerhard Christofori
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Based on their wide spectrum of target cells, FGF family members have been suspected of playing important roles in many biological events. Some members of the FGF family are potent mitogens for a large number of cell types of the mesodermal and neuroectodermal lineage, and thus could be responsible for the proliferative stimulus in tumors derived from these cells. At the same time, some of the FGFs are mitogenic for endothelial cells, and are capable of promoting tumor angiogenesis. It is therefore difficult to separate the functional role of FGFs in tumorigenesis from their role in tumor angiogenesis.

Keywords

Fibroblast Growth Factor Heparan Sulfate Tumor Angiogenesis Basic Fibroblast Growth Factor Athymic Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Israel Vlodavsky
  • Gerhard Christofori

There are no affiliations available

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