Regulation of Angiogenesis by the Organ Microenvironment

  • Diane R. Bielenberg
  • Isaiah J. Fidler
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Most deaths from cancer are caused by metastases that are resistant to conventional therapies (1–3). The major barrier to the treatment of metastases is the biological heterogeneity of cancer cells in primary and secondary neoplasms. This heterogeneity is exhibited in a wide range of biologic characteristics, such as cell-surface receptors, enzymes, karyotypes, cell morphologies, growth properties, sensitivities to various therapeutic agents, and in the ability to induce angiogenesis, and to invade and produce metastasis (3–6).


Nude Mouse Melanoma Cell Basic Fibroblast Growth Factor Human Melanoma Cell Human Colon Carcinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Diane R. Bielenberg
  • Isaiah J. Fidler

There are no affiliations available

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