Role of Inflammatory Mediators in Angiogenesis

  • Federico Bussolino
  • Alberto Mantovani
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Infiltrating leukocytes and angiogenesis are commonly observed in solid tumors and in chronic and acute inflammatory diseases. The endothelium of the vascular bed near the injured tissues actively participates to create this picture, through the formation of an interlaced network with circulating blood and/or neighboring cells and tissues. An impressive repertoire of molecules (cytokines, autacoids, growth stimulators and inhibitors, vasoactive peptides, pro- and anticoagulants, and fibrinolytic factors), with activities often partially overlapping, represent the “area codes” used to control this network, and can address endothelial cells to assume an inflammatory and/or an angiogenic phenotype (1–4).


Nitric Oxide Endothelial Cell Vascular Endothelial Growth Factor Nitric Oxide Hepatocyte Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Federico Bussolino
  • Alberto Mantovani

There are no affiliations available

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