Ribozyme Targeting of Angiogenic Molecules

  • Anton Wellstein
  • Anke M. Schulte
  • Claudius Malerczyk
  • Anne T. Tuveson
  • Achim Aigner
  • Frank Czubayko
  • Anna T. Riegel
Part of the Cancer Drug Discovery and Development book series (CDD&D)


The importance of blood vessel formation (angiogenesis) for the local growth of solid tumors and their metastatic spread is well established (1,2). A large series of correlative clinical studies published by different groups over the past seven years showed that the number of blood vessels detected in a primary tumor is an independent prognostic indicator of the outcome of the disease and is directly related to the rate of metastasis of tumors of different origin, such as breast cancer (3–8),nonsmall-cell lung cancer (9), prostate cancer (10), squamous cell carcinoma of the head and neck (11),and melanoma (12,13). In general, these studies showed that the numbers of blood vessels in a given primary tumor specimen is indicative of the rate of metastasis of the respective tumor and gives an independent measure of the outcome of the disease. Of additional significance are reports that in breast cancer patients with estrogen receptor (ER)-positive tumors, and hence apparently good prognosis, high microvessel density in the primary tumors seems to predict poor clinical outcome (8).


Melanoma Cell Basic Fibroblast Growth Factor Hammerhead Ribozyme Angiogenic Molecule WM852 Melanoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Anton Wellstein
  • Anke M. Schulte
  • Claudius Malerczyk
  • Anne T. Tuveson
  • Achim Aigner
  • Frank Czubayko
  • Anna T. Riegel

There are no affiliations available

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