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Thalidomide

A Prodrug That Inhibits Angiogenesis
  • William D. Figg
  • Eddie Reed
  • Shawn Green
  • James M. Pluda
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Thalidomide (N-phthalidoglutamide, C13 O4 N2 H9, mol wt = 258.23) (Fig. 1) is a glutamic acid derivative [S(-) and R(+) racemate] (1) that was first described in 1953 by the Swiss pharmaceutical company Ciba. Ciba discontinued research on the compound and a German company Chemie Grunenthal undertook development in 1954. It was later marketed as a sleeping pill, and was subsequently blamed for nearly 12,000 birth defects between the late 1950s and early 1960s (2).

Keywords

Teratogenic Effect Glutaric Acid Antiangiogenic Activity Lepromatous Leprosy Thalidomide Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1999

Authors and Affiliations

  • William D. Figg
  • Eddie Reed
  • Shawn Green
  • James M. Pluda

There are no affiliations available

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