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Pentosan Polysulfate

A Polysaccharide That Inhibits Angiogenesis by Binding Growth Factors

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Antiangiogenic Agents in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Sodium pentosan polysulfate (PPS; xylanopolyhydrogensulfate, Fig. 1) is a semisynthetic sulfated heparinoid polysaccharide that has been used in Europe as an anticoagulant for nearly 30 yr (1–3) It is obtained from extract of beechwood shavings, and consists of a mixture of polymers with mol wt ranging from 1.8 to 9 kDa (mean 4.7 kDa) (3). This glycosaminoglycan is a highly negatively charged compound that contains 1.9 sulfate groups per monosaccharide unit.

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Authors
  1. William D. Figg
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  2. James M. Pluda
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  3. Oliver Sartor
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Editor information

Editors and Affiliations

  1. Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA

    Beverly A. Teicher

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© 1999 Springer Science+Business Media New York

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Figg, W.D., Pluda, J.M., Sartor, O. (1999). Pentosan Polysulfate. In: Teicher, B.A. (eds) Antiangiogenic Agents in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-453-5_21

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  • DOI: https://doi.org/10.1007/978-1-59259-453-5_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4518-4

  • Online ISBN: 978-1-59259-453-5

  • eBook Packages: Springer Book Archive

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