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Pentosan Polysulfate

A Polysaccharide That Inhibits Angiogenesis by Binding Growth Factors
  • William D. Figg
  • James M. Pluda
  • Oliver Sartor
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Sodium pentosan polysulfate (PPS; xylanopolyhydrogensulfate, Fig. 1) is a semisynthetic sulfated heparinoid polysaccharide that has been used in Europe as an anticoagulant for nearly 30 yr (1–3) It is obtained from extract of beechwood shavings, and consists of a mixture of polymers with mol wt ranging from 1.8 to 9 kDa (mean 4.7 kDa) (3). This glycosaminoglycan is a highly negatively charged compound that contains 1.9 sulfate groups per monosaccharide unit.

Keywords

Interstitial Cystitis Anticoagulant Activity Pentosan Polysulfate Euglobulin Clot Lysis Time Hepatic Triglyceride Lipase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • William D. Figg
  • James M. Pluda
  • Oliver Sartor

There are no affiliations available

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