Thalidomide and Analogs

  • Taturo Udagawa
  • Henk M. W. Verheul
  • Robert J. D’Amato
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Thalidomide was developed in 1958 by Chemie Grunenthal as an oral sedative. Subsequently, McBride (1) and Lenz (2) described the association between maternal usage of thalidomide and fetal limb defects. The effect of thalidomide as a teratogen was experimentally confirmed in a number of species (3–8). By the time thalidomide was withdrawn from the market in 1962, thousands of babies worldwide were estimated to have been born with thalidomide-related defects. As a consequence, the mechanism by which thalidomide causes birth defects has been intensively investigated. Nevertheless, the mechanism has remained elusive (9).


Vascular Endothelial Growth Factor Human Microvascular Endothelial Cell Corneal Neovascularization Rabbit Cornea Lepromatous Leprosy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Taturo Udagawa
  • Henk M. W. Verheul
  • Robert J. D’Amato

There are no affiliations available

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