Dietary and Nutritional Modulation of Tumor Angiogenesis

  • Purna Mukherjee
  • Jin-Rong Zhou
  • Alexander V. Sotnikov
  • Steven K. Clinton
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Tumor angiogenesis is intimately linked to the dynamic interactions between the nutrient status of the host and the tumor. It is well recognized that a growing tumor requires a vascular supply to provide oxygen, and to remove metabolic waste (1–4). The tumor vasculature also provides the pathway for the delivery of energy-yielding com-pounds to fuel metabolism, required vitamins and minerals to serve as catalysts and critical cofactors for enzymes, essential building blocks for cellular macromolecules, and substrates for intracellular signaling pathways that cannot be synthesized by cells. There-fore, from the perspective of the tumor microenvironment, it is probable that cancer cells may alter the synthesis or balance of angiogenic and antiangiogenic factors in response to nutritional and metabolic needs. Furthermore, the nutritional status of the host modulates concentrations of circulating hormones and growth factors, or the availability of nutrients that may directly influence tumor cell proliferation and metabolism, as well as the response of the tumor vascular compartment to regulatory signals in the local environment. Although direct evidence for these concepts, derived from carefully designed experiments, is only beginning to emerge, the rapid development of laboratory models and tools for the evaluation of tumor angiogenesis provides the foundation for scientific inquiry (5).


Vascular Endothelial Growth Factor Retinoic Acid Energy Intake Vascular Endothelial Growth Factor Expression Chronic Food Restriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Purna Mukherjee
  • Jin-Rong Zhou
  • Alexander V. Sotnikov
  • Steven K. Clinton

There are no affiliations available

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