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Matrix Metalloproteinase Inhibitors

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Book cover Antiangiogenic Agents in Cancer Therapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Matrix metalloproteinases(MMPs) are a family of structurally related realted enzymes that are capable of degrading of the extracellular matrix. One of the earliest descriptions of MMPs was as depolymerizing enzymes, including that of small blood vessels,morefluid (1).Sudequent research has shown that these enzymes paly a central role in the tissue remodeling associated with both physiological and pathogenic processes.

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  1. Peter D. Brown
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  2. Mark Whittaker
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  1. Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA

    Beverly A. Teicher

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Brown, P.D., Whittaker, M. (1999). Matrix Metalloproteinase Inhibitors. In: Teicher, B.A. (eds) Antiangiogenic Agents in Cancer Therapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-453-5_13

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  • DOI: https://doi.org/10.1007/978-1-59259-453-5_13

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