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Human Embryonic Stem Cells pp 145–159Cite as

Differentiation of Neuroepithelia from Human Embryonic Stem Cells

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Abstract

Neural tissue is derived from the embryonic ectoderm. The initial step in the generation of the vertebrate nervous system is the specification of neuroepithelia from ectodermal cells—a process known as neural induction. The specified neuroepithelia in the midline dorsal ectoderm rapidly grow into a pseudostratified layer of neural plate, which later folds and closes to form the neural tube, the rudiment of the central nervous system (CNS). The lateral lip of the neural plate detaches when the neural plate closes and gives rise to neural crest derivatives. In mouse, neural plate forms at embryonic day 7, whereas in humans, it develops around embryonic day 18 (1).

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Authors
  1. Su-Chun Zhang
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Editors and Affiliations

  1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

    Arlene Y. Chiu

  2. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

    Mahendra S. Rao

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© 2003 Springer Science+Business Media New York

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Zhang, SC. (2003). Differentiation of Neuroepithelia from Human Embryonic Stem Cells. In: Chiu, A.Y., Rao, M.S. (eds) Human Embryonic Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-423-8_8

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  • DOI: https://doi.org/10.1007/978-1-59259-423-8_8

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-484-5

  • Online ISBN: 978-1-59259-423-8

  • eBook Packages: Springer Book Archive

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