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Human Embryonic Stem Cells pp 219–236Cite as

Hematopoietic Progenitors Derived from Human Embryonic Stem Cells

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Abstract

The field of hematology has pioneered both basic research and clinical applications of stem cell biology. Over 40 yr ago, studies to demonstrate clonal cells within bone marrow could be transferred between animals and give rise to multiple blood cell lineages within the spleen were the first experiments to define basic stem cell principles—the ability for a single cell to both self-renew and differentiate into two or more cell types (1,2).Subsequent clinical studies showed the effectiveness of bone marrow transplantation to effectively treat and cure a variety of hematologic disorders, including (but not limited to) aplastic anemia, immunodeficienies, leukemia, lymphoma, and multiple myeloma. Indeed, the National Marrow Donor Program now identifies over 50 diseases that can be treated by bone marrow transplantation. Therefore, although “stem cell therapy” is often described as futuristic medicine, it should be remembered that bone marrow transplantation is, indeed, a form of stem cell therapy and has been successfully used for over three decades (3).

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  1. Dan S. Kaufman
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Editors and Affiliations

  1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

    Arlene Y. Chiu

  2. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

    Mahendra S. Rao

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Kaufman, D.S. (2003). Hematopoietic Progenitors Derived from Human Embryonic Stem Cells. In: Chiu, A.Y., Rao, M.S. (eds) Human Embryonic Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-423-8_12

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  • DOI: https://doi.org/10.1007/978-1-59259-423-8_12

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