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Ethical Issues Associated with Pluripotent Stem Cells

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Human Embryonic Stem Cells

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Abstract

The announcement in February 1997 by researchers at the Roslin Institute in Edinburgh, Scotland of the successful cloning of a sheep named Dolly from adult mammary cells surprised the scientific community and captured the public’s attention, provoking hopeful comments from political leaders, religious figures, and eminent scientists about potential benefits, as well as expressions of fears that it could lead to profound ethical transgressions. The media instantly extrapolated from the creation of a lamb to the potential cloning of humans—one of the first newspaper headlines was “Sheep Clone Raises Alarm Over Humans” (1)—and governments scrambled to develop policies to address public concerns. The initial outcry over the potential use of somatic cell nuclear transfer (SCNT) to clone humans was followed by a broader debate about the ethics of the new avenues of medical research that had been opened by new technology, especially the potential to create human embryos that could be used in research and/or therapies.

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References

  1. Sheep clone raises alarm over humans, The Sunday Times (London),23 February 1997.

    Google Scholar 

  2. Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., et al. (1998) Embryonic stem cell lines derived from human blastocysts, Science 282, 1145 - 1147.

    Article  PubMed  CAS  Google Scholar 

  3. Shamblott, M. J., Axelman, J., Wang, S., et al. (1998) Derivation of pluripotent stem cells from cultured human primordial germ cells, PNAS 95, 13, 726-13, 731.

    Google Scholar 

  4. Statement of Harold Varmus, Director, National Institutes of Health, before the Senate Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies, December 2, 1998. Available from http://www.nih.gov/about/director/120298.htm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  5. Press release: NIH publishes final guidelines for stem cell research, August 23, 2000. Available from http://www.nih.gov/news/pr/aug2000/od-23.htm./users/rhatch/SAM-V-Z.htm

  6. Center for Bioethics and Human Dignity. Using stem cells from embryos will make human flesh profitable, June 29, 2001. Available from http://www.cbad.org/resources/aps/dsm-stemcell.htm./users/rhatch/SAM-V-Z.htm

  7. Center for Bioethics and Human Dignity. On human embryos and stem cell research: an appeal for legally and ethically responsible science and public policy, April 26, 2000. Available from http://www.stemcellresearch.org/statement/statement.htm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  8. Encyclical letter Evangelium Vitae,addressed by The Supreme Pontiff John Paul II to the bishops, priests and deacons, men and women, religious lay faithful and all people of good will on the value and inviolability of human life, 1995. Available from http://www.vatican.va/holy_father/john_paul_ii/encyclicals/documents/hfjp-ii_enc_25031995_evangelium-vitae_en.html./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  9. Testimony of Richard M. Doerflinger on behalf of the Committee for Pro-Life Activities United States Conference of Catholic Bishops before the Subcom- mittee on Labor, Health and Human Services, and Education Senate Appropriations Committee Hearing on Stem Cell Research, July 18, 2001. Available from http://www.usccb.org/prolife/issues/bioethic/stemcelltest71801.htm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  10. Doerflinger, R. M. (1999) The ethics of funding embryonic stem cell research: a Catholic viewpoint, Kennedy Inst. Ethics J. 9 (2), 137 - 150.

    Article  PubMed  Google Scholar 

  11. General Board of Church and Society, The United Methodist Church, General Secretary’s letter to President Bush to extend moratorium on human embryo stem cell research, July 17, 2001. Available from http://www.umc-gbcs.org/gbpr/users/rhatch/SAM-V-Z.htm118a.

    Google Scholar 

  12. Background Paper on the Donaldson Report, Society Religion & Technology Project, and the Board of Social Responsibility of the Church of Scotland, 16 August 2000. Available from dspace.dial.pipex.com/srtscot/clonin41.

    Google Scholar 

  13. Using stem cells from embryos will make human flesh profitable, June 29, 2001. Available from http://www.cbhd.org/resources/aps/dsm-stemcell./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  14. Overture 01-50. On adopting a resolution enunciating ethical guidelines for fetal tissue and stem cell research-from the Presbytery of Baltimore, June 16, 2001. Available from http://www.pcusa.org/ga213/business/OVT0150./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  15. National Bioethics Advisory Commission report on ethical issues in human stem cell research, volume III, religious perspectives, p. C3, May 1999. Available from http://www.georgetown.edu/research/nrcbl/nbac/stemce113./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  16. Letter to President George W. Bush from the leaders of American Reformed Jews, July 2001. Available from uahc.org/reform/rac/news/071601.

    Google Scholar 

  17. Outka, G. The ethics of stem cell research, April 2000. Available from http://www.bioethics.gov/outka./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  18. Testimony of The Honorable Orrin G. Hatch before the Senate Appropriations Committee Subcommittee on Labor-HHHS-Stem Cell Research, July 18, 2001. Available from http://www.senate.gov/-hatch/index.cfm?FuseAction=Topics. Detail&PressRelease id=177442&Month=7&Year=2001./users/rhatch/SAM-V-Z.htm

  19. Shannon, T. A. (1998) Remaking ourselves? The ethics of stem-cell research, Commonweal 125 (21), 9.

    PubMed  CAS  Google Scholar 

  20. Testimony of Richard O. Hynes, Ph.D., President, American Society for Cell Biology to the Labor, Health & Human Services and Education Subcommittee of the Appropriations Committee, United States Senate, September 14, 2000. Available from http://www.ascb.org/publicpolicy/hynessctest./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  21. Testimony of Lawrence S. B. Goldstein, Ph.D., representing the American Society for Cell Biology to the Labor, Health & Human Services and Education Subcommittee of the Appropriations Committee, United States Senate, April 26, 2000. Available from http://www.ascb.org/publicpolicy/goldsteinsctest./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  22. Usdin, S. (1998) Cloning showdown comes quickly, Feb. 9, 1998. BioCentury 6 (12).

    Google Scholar 

  23. Biotechnology Industry Organization, Statement of the biotechnology industry organization regarding legislation introduced to ban human cloning, Feb. 10, 1998. Available from thomas.loc.gov/cgi-bin/query/C?r105:./temp/-r 1057B0Obr.

    Google Scholar 

  24. Usdin, S. and Zipkin, I. (1998) NIH wants in, BioCentury.

    Google Scholar 

  25. Usdin, S. (1999) Lawmakers fire back at Varmus, Feb. 22, 1999, BioCentury, 7 (12).

    Google Scholar 

  26. National Bioethics Advisory Commission report on ethical issues in human stem cell research, volume I, p. 88, September 1999. Available from http://www.georgetown.edu/research/nrcbl/nbac/stemcell.pdf./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  27. National Bioethics Advisory Commission report on ethical issues in human stem cell research, executive summary, p. 4, September 1999. Available from http://www.georgetown.edu/research/nrcbl/nbac/execsumm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  28. White House Statement on Human Stem Cell Research, July 14, 1999.

    Google Scholar 

  29. Federal Register Notice: Draft NIH Guidelines for Research Involving Human Pluripotent Stem Cells, December 1999. Available from http://www.nih.gov/news/stemcell/draftguidelines.htm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  30. NIH Publishes Final Guidelines for Stem Cell Research, August 23, 2000. Available from http://www.nih.gov/news/pr/aug2000/od-23.htm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  31. Vogel, G. (2001) NIH pulls plug on ethics review, Science 292, 415 - 416.

    Article  PubMed  CAS  Google Scholar 

  32. Chief Medical Officer“s Expert Group on Therapeutic Cloning report on Stem Cells: Medical Progress with Responsibility,” p. 7, August 16, 2000. Available from http://www.doh.gov.uk/cegc/stemcellreport.htm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  33. Nuffield Council on Bioethics (2000) Stem cell therapy: the ethical issues, a discussion paper. Available from http://www.nuffieldbioethics.org/publications/stemcells/rep0000000299.asp/users/rhatch/SAM-V-Z.htm

    Google Scholar 

  34. Wess, L. (2002) German stem cell schizophrenia, April 29, 2002. BioCentury 10 (19).

    Google Scholar 

  35. Bioethics Advisory Committee (2000) Ethical legal and social issues in human stem cell research, reproductive and therapeutic cloning. Available from http://www.bioethics-singapore.org/bac/detailed.jsp?artid=33&typeid=l&cid= 35&bSubmitBy=false./users/rhatch/SAM-V-Z.htm

    Google Scholar 

  36. The Conference on Beyond Determinism and Reductionism: Genetic Science and the Person, 2002. Available from http://www.gov.sg/singov/announce/170702tt.htm./users/rhatch/SAM-V-Z.htm

    Google Scholar 

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Authors
  1. Steve Usdin
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Editors and Affiliations

  1. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

    Arlene Y. Chiu

  2. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

    Mahendra S. Rao

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© 2003 Springer Science+Business Media New York

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Usdin, S. (2003). Ethical Issues Associated with Pluripotent Stem Cells. In: Chiu, A.Y., Rao, M.S. (eds) Human Embryonic Stem Cells. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-423-8_1

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  • DOI: https://doi.org/10.1007/978-1-59259-423-8_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-484-5

  • Online ISBN: 978-1-59259-423-8

  • eBook Packages: Springer Book Archive

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