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Parkinson’s Disease: Etiologic Considerations

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Parkinson’s Disease and Movement Disorders

Part of the book series: Current Clinical Practice ((CCP))

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Abstract

Parkinson’ s disease (PD) is associated with distinctive and highly localized pathologic changes in the brain. Degeneration of substantia nigra pars compacta neurons within the midbrain is pronounced in patients with PD. These dopaminergic neurons project to the striatum, and loss of striatal dopamine is responsible for most of the motor deficits of PD.

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Authors
  1. Peter A. LeWitt MD
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Editor information

Editors and Affiliations

  1. Parkinson’s Disease and Movement, Disorders Center, Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, AZ, USA

    Charles H. Adler MD, PhD (Consultant and Co-Director, Associate Professor of Neurology) (Consultant and Co-Director, Associate Professor of Neurology)

  2. Mayo Medical School, Rochester, MN, USA

    Charles H. Adler MD, PhD (Consultant and Co-Director, Associate Professor of Neurology) & J. Eric Ahlskog PhD, MD (Chair, Consultant, Professor of Neurology) (Consultant and Co-Director, Associate Professor of Neurology) &  (Chair, Consultant, Professor of Neurology)

  3. Division of Movement Disorders, Department of Neurology, Mayo Clinic Rochester, Rochester, MN, USA

    J. Eric Ahlskog PhD, MD (Chair, Consultant, Professor of Neurology) (Chair, Consultant, Professor of Neurology)

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© 2000 Springer Science+Business Media New York

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LeWitt, P.A. (2000). Parkinson’s Disease: Etiologic Considerations. In: Adler, C.H., Ahlskog, J.E. (eds) Parkinson’s Disease and Movement Disorders. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-410-8_6

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  • DOI: https://doi.org/10.1007/978-1-59259-410-8_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-095-3

  • Online ISBN: 978-1-59259-410-8

  • eBook Packages: Springer Book Archive

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