Abstract
Progressive supranuclear palsy (PSP) is the most common of a group of idiopathic neurodegenerative disorders classified as the parkinsonism-plus syndromes. As the term “parkinsonism-plus syndrome” implies, patients usually have neurologic symptoms in addition to those of Parkinson’s disease (PD). The pathologic involvement in these conditions, including PSP, is more widespread than that in typical PD. The four classic symptoms of PD—bradykinesia, rigidity, resting tremor, and postural instability—primarily result from pathology within the substantia nigra, a component of the basal ganglia pathways. In PSP, additional basal ganglia nuclei are involved, as are other subcortical areas and sometimes the cortex (especially frontal). The clinical hallmarks of PSP—down-gaze paresis, falling early in the course, and other features noted below—reflect this extranigral pathologic involvement.
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Stacy, M. (2000). Progressive Supranuclear Palsy. In: Adler, C.H., Ahlskog, J.E. (eds) Parkinson’s Disease and Movement Disorders. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-410-8_16
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DOI: https://doi.org/10.1007/978-1-59259-410-8_16
Publisher Name: Humana Press, Totowa, NJ
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Online ISBN: 978-1-59259-410-8
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