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Nitric Oxide

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Combat Medicine

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Abstract

Nitric oxide (NO) is involved in numerous physiologic functions ranging from regulation of cardiovascular functions to participating in memory (1–4). In the immune system, this diatomic radical is involved in host defense and has tumoricidal functions (5,6) However, despite these properties, which are critical in maintaining homeostasis, NO has been implicated as a participant or causative agent in a variety of pathophysiologic conditions (7,8). Defining the exact role of NO under pathophysiologic conditions is further complicated by the fact that it has been shown to be both protective as well as deleterious even in the context of the same biologic setting. Therefore, the search for mechanistic explanations to account for these differing effects is ongoing.

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Authors
  1. Douglas D. Thomas PhD
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  2. Katrina M. Miranda PhD
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  3. Deborah Citrin MD
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  4. Michael G. Espey PhD
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  1. Walter Reed Army Institute of Research, Silver Spring, MD, USA

    George C. Tsokos MD  & James L. Atkins MD  & 

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Thomas, D.D., Miranda, K.M., Citrin, D., Espey, M.G., Wink, D.A. (2003). Nitric Oxide. In: Tsokos, G.C., Atkins, J.L. (eds) Combat Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-407-8_2

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  • DOI: https://doi.org/10.1007/978-1-59259-407-8_2

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