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Neuroendocrine Differentiation Patterns in Various Organs (Including Lung, Breast, Skin, and Urogenital Tract)

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Endocrine Pathology

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Abstract

Neuroendocrine (NE) differentiation implies production, storage, and release of appropriate peptide hormones and biogenic amines, acting on target cells through specific receptors via endocrine, paracrine, or autocrine pathways [1]. NE cells constituting the diffuse NE system are present in various organs, dispersed among exocrine cells. They were first extensively investigated in the gastrointestinal tract and pancreas, initially by silver-staining procedures and ultrastructural analysis, and it was soon realized that they have common characteristics, both structural (such as cytoplasmic neurosecretory granules and clear vesicles) and functional [2]. The latter constitutes a vast array of markers, which can now be traced by immunocytochemical procedures, thus acquiring diagnostic interest.

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Authors
  1. Marco Volante MD
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  2. Anna Sapino MD
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  3. Mauro Papotti MD
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  4. Donatella Pacchioni MD
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  5. Gianni Bussolati MD, FRCPath
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Editors and Affiliations

  1. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Ricardo V. Lloyd MD, PhD

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Volante, M., Sapino, A., Papotti, M., Pacchioni, D., Bussolati, G. (2004). Neuroendocrine Differentiation Patterns in Various Organs (Including Lung, Breast, Skin, and Urogenital Tract). In: Lloyd, R.V. (eds) Endocrine Pathology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-403-0_18

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  • DOI: https://doi.org/10.1007/978-1-59259-403-0_18

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