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Classification of Human Lung Carcinomas by mRNA Expression Profiling

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Expression Profiling of Human Tumors

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Abstract

Lung cancer deaths exceed the combined mortality from breast, prostate, and colorectal cancers (1). Every year more than 150,000 Americans die from this deadly disease. Lung carcinoma classes include small cell lung carcinomas (SCLC) and nonsmall cell lung carcinomas (NSCLC). The distinction of SCLC from NSCLC is important as the clinical course and treatments for the two diseases are different. SCLC patients initially respond well to chemotherapy, followed by regression of the tumor. However, in most cases, the patient relapses, develops chemoresistance, and eventually dies from systemic dissemination of cancer. In contrast, in early stage NSCLC disease, treatment involves surgical removal of primary tumor (resection). However, 50% of those patients undergo relapse and eventually die from metastasis.

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References

  1. Greenlee, R. T., Hill-Harmon, M. B., Murray, T., and Thun, M. (2001) Cancer statistics, 2001. CA Cancer J. Clin. 51, 15–36.

    Article  PubMed  CAS  Google Scholar 

  2. Travis, W. D., Colby, T. V., Conin, B., Shimosato, Y., and Brambilla, E. (1999) Histological typing of lung and pleural tumors, in World Health Organization International Histological Classification of Tumors. Springer Verlag, Berlin.

    Google Scholar 

  3. Ramaswamy, S., Tamayo, P., Rifkin, R., et al. (2001) Multiclass cancer diagnosis using tumor gene expression signatures. Proc. Natl. Acad. Sci. USA 98, 15,149–15, 154.

    Google Scholar 

  4. Druker, B. J., Talpaz, M., Resta, D. J., et al. (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344, 1031–1037.

    Article  PubMed  CAS  Google Scholar 

  5. Travis, W. D., Travis, L. B., and Devesa, S. S. (1995) Lung cancer. Cancer 75, 191–202.

    Article  PubMed  CAS  Google Scholar 

  6. Bennett, W. P., Hussain, S. P., Vahakangas, K. H., Khan, M. A., Shields, P. G., and Harris, C. C. (1999) Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer. J. Pathol. 187, 8–18.

    Article  PubMed  CAS  Google Scholar 

  7. Hainaut, P., Olivier, M., and Pfeifer, G. P. (2001) TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database. Mutagenesis 16, 551–553.

    Article  PubMed  CAS  Google Scholar 

  8. Kim, D. H., Nelson, H. H., Wiencke, J. K., et al. (2001) p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res. 61, 3419–3424.

    Google Scholar 

  9. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. (1991) p53 mutations in human cancers. Science 253, 49–53.

    Google Scholar 

  10. Levine, A. J., Momand, J., and Finlay, C. A. (1991) The p53 tumour suppressor gene. Nature 351, 453–456.

    Article  PubMed  CAS  Google Scholar 

  11. Gazdar, A. F. (1994) The molecular and cellular basis of human lung cancer. Anticancer Res. 14, 261–267.

    PubMed  CAS  Google Scholar 

  12. Sorensen, J. B., Hirsch, F. R., Gazdar, A., and Olsen, J. E. (1993) Interobserver variability in histopathologic subtyping and grading of pulmonary adenocarcinoma. Cancer 71, 29712976.

    Google Scholar 

  13. Breathnach, O. S., Ishibe, N., Williams, J., Linnoila, R. I., Caporaso, N., and Johnson, B. E. (1999) Clinical features of patients with stage IIIB and IV bronchioloalveolar carcinoma of the lung. Cancer 86, 1165–1173.

    Article  PubMed  CAS  Google Scholar 

  14. Breathnach, O. S., Kwiatkowski, D. J., Finkelstein, D. M., et al. (2001) Bronchioloalveolar carcinoma of the lung: recurrences and survival in patients with stage I disease. J. Thorac. Cardiovasc. Surg. 121, 42–47.

    Article  PubMed  CAS  Google Scholar 

  15. Flint, A. and Lloyd, R. V. (1992) Pulmonary metastases of colonic carcinoma. Distinction from pulmonary adenocarcinoma. Arch. Pathol. Lab. Med. 116, 39–42.

    PubMed  CAS  Google Scholar 

  16. Shirakusa, T., Tsutsui, M., Motonaga, R., Ando, K., and Kusano, T. (1988) Resection of metastatic lung tumor: the evaluation of histologic appearance in the lung. Am. Surg. 54, 655–658.

    PubMed  CAS  Google Scholar 

  17. Mountain, C. F. (2000) The international system for staging lung cancer. Semin. Surg Oncol. 18, 106–115.

    Article  PubMed  CAS  Google Scholar 

  18. Chee, M., Yang, R., Hubbell, E., et al. (1996) Accessing genetic information with high-density DNA arrays. Science 274, 610–614.

    Article  PubMed  CAS  Google Scholar 

  19. Lockhart, D. J., Dong, H., Byrne, M. C., et al. (1996) Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat. Biotechnol. 14, 1675–1680.

    Article  PubMed  CAS  Google Scholar 

  20. Schena, M., Shalon, D., Davis, R. W., and Brown, P. O. (1995) Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467–470.

    Article  PubMed  CAS  Google Scholar 

  21. Schena, M., Shalon, D., Heller, R., Chai, A., Brown, P. 0., and Davis, R. W. (1996) Parallel human genome analysis: microarray-based expression monitoring of 1000 genes. Proc. Natl. Acad. Sci. USA 93, 10, 614–10, 619.

    Google Scholar 

  22. Alizadeh, A. A., Eisen, M. B., Davis, R. E., et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, 503–511.

    Article  PubMed  CAS  Google Scholar 

  23. Alon, U., Barkai, N., Notterman, D. A., et al. (1999) Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc. Natl. Acad. Sci. USA 96, 6745–6750.

    Article  PubMed  CAS  Google Scholar 

  24. Bittner, M., Meltzer, P., Chen, Y., et al. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406, 536–540.

    Article  PubMed  CAS  Google Scholar 

  25. Golub, T. R., Slonim, D. K., Tamayo, P., et al. (1999) Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531–537.

    Article  PubMed  CAS  Google Scholar 

  26. Khan, J., Wei, J. S., Ringner, M., et al. (2001) Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat. Med. 7, 673–679.

    Article  PubMed  CAS  Google Scholar 

  27. Perou, C. M., Sorlie, T., Eisen, M. B., et al. (2000) Molecular portraits of human breast tumours. Nature 406, 747–752.

    Article  PubMed  CAS  Google Scholar 

  28. Welsh, J. B., Zarrinkar, P. P., Sapinoso, L. M., et al. (2001) Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc. Natl. Acad. Sci. USA 98, 1176–1181.

    Article  PubMed  CAS  Google Scholar 

  29. Bhattacharjee, A., Richards, W. G., Staunton, J., et al. (2001) Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc. Natl. Acad. Sci. USA 98, 13,790–13, 795.

    Google Scholar 

  30. Garber, M. E., Troyanskaya, O. G., Schluens, K., et al. (2001) Diversity of gene expression in adenocarcinoma of the lung. Proc. Natl. Acad. Sci. USA 98, 13,784–13, 789.

    Google Scholar 

  31. Nacht, M., Dracheva, T., Gao, Y., et al. (2001) Molecular characteristics of non-small cell lung cancer. Proc. Natl. Acad. Sci. USA 98, 15,203–15, 208.

    Google Scholar 

  32. Su, A. I., Welsh, J. B., Sapinoso, L. M., et al. (2001) Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res. 61, 7388–7393.

    PubMed  CAS  Google Scholar 

  33. Sunday, M. E., Haley, K. J., Sikorski, K., et al. (1999) Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. Oncogene 18, 4336–4347.

    Article  PubMed  CAS  Google Scholar 

  34. Linnoila, R. I., Zhao, B., DeMayo, J. L., et al. (2000) Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice. Cancer Res. 60, 4005–4009.

    PubMed  CAS  Google Scholar 

  35. Jackson, E. L., Willis, N., Mercer, K., et al. (2001) Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dey. 15, 3243–3248.

    Article  CAS  Google Scholar 

  36. Johnson, L., Mercer, K., Greenbaum, D., et al. (2001) Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410, 1111–1116.

    Article  PubMed  CAS  Google Scholar 

  37. Meuwissen, R., Linn, S. C., van der Valk, M., Mooi, W. J., and Berns, A. (2001) Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene. Oncogene 20, 6551–6558.

    Article  PubMed  CAS  Google Scholar 

  38. Fisher, G. H., Wellen, S. L., Klimstra, D., et al. (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev. 15, 3249–3262.

    Article  PubMed  CAS  Google Scholar 

  39. Scherf, U., Ross, D. T., Waltham, M., et al. (2000) A gene expression database for the molecular pharmacology of cancer. Nat. Genet. 24, 236–244.

    Article  PubMed  CAS  Google Scholar 

  40. Staunton, J. E., Slonim, D. K., Coller, H. A., et al. (2001) Chemosensitivity prediction by transcriptional profiling. Proc. Natl. Acad. Sci. USA 98, 10,787–10, 792.

    Google Scholar 

  41. Ge, H., Liu, Z., Church, G. M., and Vidal, M. (2001) Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae. Nat. Genet. 29, 482–486.

    Article  CAS  Google Scholar 

  42. Graeber, T. G. and Eisenberg, D. (2001) Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles. Nat. Genet. 29, 295–300.

    Article  PubMed  CAS  Google Scholar 

  43. Roberts, C. J., Nelson, B., Marton, M. J., et al. (2000) Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287, 873–880.

    Article  PubMed  CAS  Google Scholar 

  44. Eisen, M. B., Spellman, P. T., Brown, P. 0., and Botstein, D. (1998) Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 95, 14, 86314, 868.

    Google Scholar 

  45. Cheeseman, P. and Stutz, J. (1996) Bayesian classification (autoclass): theory and results, in Advances in Knowledge Discovery and Data Mining ( Fayyad, U. M., Piatetsky-Shapiro, G., Smyth, P., and Uthurasamy, R., eds.), MIT Press, Cambridge.

    Google Scholar 

  46. Kang, Y., Prentice, M. A., Mariano, J. M., et al. (2000) Transforming growth factor-beta 1 and its receptors in human lung cancer and mouse lung carcinogenesis. Exp. Lung Res. 26, 685–707.

    Article  PubMed  CAS  Google Scholar 

  47. Lan, M. S., Russell, E. K., Lu, J., Johnson, B. E., and Notkins, A. L. (1993) IA-1, a new marker for neuroendocrine differentiation in human lung cancer cell lines. Cancer Res. 53, 4169–4171.

    PubMed  CAS  Google Scholar 

  48. Ball, D. W., Azzoli, C. G., Baylin, S. B., et al. (1993) Identification of a human achaetescute homolog highly expressed in neuroendocrine tumors. Proc. Natl. Acad. Sci. USA 90, 5648–5652.

    Article  PubMed  CAS  Google Scholar 

  49. Anbazhagan, R., Tihan, T., Bornman, D. M., et al. (1999) Classification of small cell lung cancer and pulmonary carcinoid by gene expression profiles. Cancer Res. 59, 5119–5122.

    PubMed  CAS  Google Scholar 

  50. Yang, A., Schweitzer, R., Sun, D., et al. (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398, 714–718.

    Google Scholar 

  51. Giordano, T. J., Shedden, K. A., Schwartz, D. R., et al. (2001) Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am. J. Pathol. 159, 1231–1238.

    Article  PubMed  CAS  Google Scholar 

  52. Berendsen, H. H., de Leij, L., Poppema, S., et al. (1989) Clinical characterization of nonsmall-cell lung cancer tumors showing neuroendocrine differentiation features. J. Clin. Oncol. 7, 1614–1620.

    PubMed  CAS  Google Scholar 

  53. Skov, B. G., Sorensen, J. B., Hirsch, F. R., Larsson, L. I., and Hansen, H. H. (1991) Prognostic impact of histologic demonstration of chromogranin A and neuron specific enolase in pulmonary adenocarcinoma. Ann. Oncol. 2, 355–360.

    PubMed  CAS  Google Scholar 

  54. Vio, C. P., Olavarria, V., Gonzalez, C., Nazal, L., Cordova, M., and Balestrini, C. (1998) Cellular and functional aspects of the renal kallikrein system in health and disease. Biol. Res. 31, 305–322.

    Article  PubMed  CAS  Google Scholar 

  55. Ciardiello, F. and Tortora, G. (2001) A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin. Cancer Res. 7, 2958–2970.

    PubMed  CAS  Google Scholar 

  56. Nemunaitis, J., Cunningham, C., Buchanan, A., et al. (2001) Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity. Gene Ther. 8, 746–759.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Arindam Bhattacharjee
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  2. Matthew Meyerson
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Editor information

Editors and Affiliations

  1. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Marc Ladanyi MD  & William L. Gerald MD, PhD  & 

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Bhattacharjee, A., Meyerson, M. (2003). Classification of Human Lung Carcinomas by mRNA Expression Profiling. In: Ladanyi, M., Gerald, W.L. (eds) Expression Profiling of Human Tumors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-386-6_11

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  • DOI: https://doi.org/10.1007/978-1-59259-386-6_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-375-6

  • Online ISBN: 978-1-59259-386-6

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