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Cardiac Markers pp 369–377Cite as

B-Type Natriuretic Peptide

Biochemistry and Measurement

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Part of the book series: Pathology and Laboratory Medicine ((PLM))

Abstract

In 1988, Sudoh and co-workers first isolated a novel peptide from porcine brain and designated the peptide “brain natriuretic peptide,” or BNP, based on its similarity to atrial natriuretic peptide (ANP) (1). BNP also was isolated from the cardiac tissue of pigs, rats, and humans (2–5). Owing to its presence in cardiac tissue, the designation “brain natriuretic peptide” is a misnomer. Hence, the designation “B-type natriuretic peptide” is currently used. Subsequent immunological studies identified the cardiac ventricle as the major source of circulating BNP in humans (6). Additional studies indicated that the left ventricle is the major source of circulating BNP and that the release of BNP into the circulation is stimulated by increased ventricular wall tension and volume overload (7–11).

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Authors
  1. Jeffrey R. Dahlen
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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    Alan H. B. Wu PhD

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© 2003 Springer Science+Business Media New York

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Dahlen, J.R. (2003). B-Type Natriuretic Peptide. In: Wu, A.H.B. (eds) Cardiac Markers. Pathology and Laboratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-385-9_23

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  • DOI: https://doi.org/10.1007/978-1-59259-385-9_23

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-319-0

  • Online ISBN: 978-1-59259-385-9

  • eBook Packages: Springer Book Archive

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