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Standardization of Cardiac Markers

  • Chapter
Book cover Cardiac Markers

Part of the book series: Pathology and Laboratory Medicine ((PLM))

Abstract

The development of commercially available assays for the determination of cardiac proteins has been one of the most important innovations in the field of cardiovascular diagnostics in the last decade. The availability of innovative procedures to detect myoglobin, creatine kinase isoenzyme MB (CK-MB) mass concentration, and, above all, cardiac troponins now represents a major opportunity to improve significantly clinical assessment of the acute coronary syndrome (ACS) (1). The routine clinical use of the measurement of the catalytic activity of “cardiac” enzymes, that is, lactate dehydrogenase, aspartate aminotransferase, CK and CK-MB, has gradually been replaced—although at different speeds in various countries—by automated quantitative immunoassays for mass determination of myoglobin, CK-MB, cardiac troponin I (cTnI), and cardiac troponin T (cTnT) (2).

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Authors
  1. Mauro Panteghini
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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

    Alan H. B. Wu PhD

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Panteghini, M. (2003). Standardization of Cardiac Markers. In: Wu, A.H.B. (eds) Cardiac Markers. Pathology and Laboratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-385-9_13

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  • DOI: https://doi.org/10.1007/978-1-59259-385-9_13

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-319-0

  • Online ISBN: 978-1-59259-385-9

  • eBook Packages: Springer Book Archive

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