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Early Diagnosis and Treatment of Endocrine Disorders pp 229–238Cite as

Pituitary Tumors Other Than Acromegaly

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Prolactinoma, an adenoma, is the most common hormone-secreting pituitary tumor. Pituitary tumors arise from the functioning or hormone-producing cells as well as stromal cells. The prevalence of prolactinoma in the general population is unknown. However, autopsy results demonstrate that 23–27% of individuals have pituitary microadenomas without prior clinical evidence, and 40% of these stain positive for prolactin by immunocytochemical analysis (1,2). Adenomas are frequently classified according to their size, with microadenomas being less than 10 mm in diameter and larger lesions labeled macroadenomas. Most prolactinomas are microadenomas and enlarge (if at all) extremely slowly over time. The risk of progression of untreated microadenomas to macroadenomas is approximately 7%, based on several longitudinal series of patients followed over long periods (3–8). The pathogenesis of prolactinomas is unknown. Clonal analysis of tumor DNA indicates a monoclonal origin and thus a de novo formation (9,10).

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Authors
  1. Nicholas Clarke MD
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  2. Udaya M. Kabadi MD, FRCP(C), FACP, FACE
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Editors and Affiliations

  1. Division of Endocrinology and Metabolism Department of Internal Medicine, The University of Iowa School of Medicine, Iowa City, IA, USA

    Robert S. Bar MD

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Clarke, N., Kabadi, U.M. (2003). Pituitary Tumors Other Than Acromegaly. In: Bar, R.S. (eds) Early Diagnosis and Treatment of Endocrine Disorders. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-378-1_11

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  • DOI: https://doi.org/10.1007/978-1-59259-378-1_11

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-414-2

  • Online ISBN: 978-1-59259-378-1

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