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Platelet Adhesion

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Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Platelets are born from megakaryocytes and are bred to adhere. As such, these anuclear particles represent one of the most highly specialized cells within the body. This functional dedication to adhesion is essential in order to prevent excessive bleeding from sites of vascular injury. The rapidity with which platelets seal an injured vessel is a remarkable testament to their adhesive specialization and is essential to the maintenance and/or restoration of vascular integrity. As with many physiologic systems, an overly exuberant cellular response can have major pathophysiologic consequences. In the case of platelet adhesion, the out-of-control response can be devastating, thrombosis, leading to life-threatening or debilitating pathologies.

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Authors
  1. Edward E. Plow PhD
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  1. Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, OH, USA

    A. Michael Lincoff MD

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Plow, E.E. (2003). Platelet Adhesion. In: Lincoff, A.M. (eds) Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-376-7_2

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  • DOI: https://doi.org/10.1007/978-1-59259-376-7_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-408-1

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