Abstract
Separate mechanisms supply and eliminate water to maintain fluid homeostasis. A variety of sensors modulate thirst to drive water-seeking behavior and water intake. The elimination of water is achieved via hormonal control of the kidney. To ensure that a healthy fluid balance is maintained, the mechanisms that accrue water can compensate for defects in the mechanisms that eliminate water and vice versa. Clinical problems arise when the capacity for this compensation is exceeded or when such compensation becomes unduly demanding.
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Zimmerman, D., Uramoto, G. (2003). Diabetes Insipidus in Pediatrics. In: Meikle, A.W. (eds) Endocrine Replacement Therapy in Clinical Practice. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-375-0_1
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DOI: https://doi.org/10.1007/978-1-59259-375-0_1
Publisher Name: Humana Press, Totowa, NJ
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