Skip to main content

Catharanthus roseus

  • Chapter

Abstract

An erect, bushy perennial herb of the APOCYNACEAE family which grows to 75 cm high, becoming subwoody at the base and profusely branched, the stems containing some milky latex; leaves are opposite in pairs, smooth, oblong-oval, blunt, or rounded at the apex, 2.5 to 9 cm long and 1.5 to 4 cm wide, short-petioled. Flowers borne all year in upper leaf axils, are tubular, 1.5 to 4 cm long, 5-lobed, flaring to a width of 5 cm; color may be white with a yellow eye, white with a crimson eye, or lavender-pink with a crimson eye.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Quisumbing, E. Medicinal plants of the Philippines. Tech Bull 16, Rep Philippines, Dept Agr Nat Resources, Manilla 1951; 1.

    Google Scholar 

  2. Zaguirre, J. C. Guide notes of bed-size preparations of most common local (Philippines) medicinal plants, 1944.

    Google Scholar 

  3. Ramiah, N. Occurrence of liquid alkaloids in Vinca rosea. J Indian Chem Soc 1964; 41: 552.

    CAS  Google Scholar 

  4. Leete, E., A. Ahmad and I. Kompis. Biosynthesis of the Vinca alkaloids. I. Feeding experiments with tryptophan2-C14 and acetate-1-C14. J Amer Chem Soc 1965; 87: 4168.

    Article  CAS  Google Scholar 

  5. Roger, D. and K. Stolle. A new alkaloid from Catharanthus roseus. Naturwissenschaften 1964; 51: 637.

    Article  Google Scholar 

  6. Spencer, C. F., F. R. Koniuszy, E. F. Rogers et al. Survey of plants for antimalarial activity. Lloydia 1947; 10: 145–174.

    Google Scholar 

  7. Cordell, G. A., S. G. Weiss and N. R. Farnsworth. Structure elucidation and chemistry of Catharanthus alkaloids. XXX. Isolation and structure of vincarodine. J Org Chem 1974; 39(4): 431–434.

    Article  PubMed  CAS  Google Scholar 

  8. Patterson, B. D. and D. P. Carew. Growth and alkaloid formation in Catharanthus roseus tissue cultures. Lloydia 1969; 32: 131.

    PubMed  CAS  Google Scholar 

  9. Joshi, M. S. and R. Y. Ambaye. Effect of alkaloids from Vinca rosea on spermatogenesis in male rats. Indian J Exp Biol 1968; 6: 256,257.

    Google Scholar 

  10. Noble, R. L., C. T. Beer and J. H. Cutts. Role of chance observations in chemotherapy: Vinca rosea. Ann NY Acad Sci 1958; 76: 882,

    Article  PubMed  CAS  Google Scholar 

  11. Svoboda, G. H. Alkaloids of Vinca rosea (Catharanthus roseus). XX. Perividine. Lloydia 1963; 26: 243.

    CAS  Google Scholar 

  12. Jovanovics, K., K. Szasz, G. Pekete, E. Bittner E. Dezseri and J. Eles. Increasing the yield of vincristine when separating vincristine from Vinca rosea drug. Patent-S Afr08,534 1973; 72.

    Google Scholar 

  13. Guarnaccia, R. and C. J. Coscia. Occurrence and biosynthesis of secologanic acid in Vinca rosea. J Amer Chem Soc 1971; 93: 6320.

    Article  CAS  Google Scholar 

  14. Groger, D., K. Stolle and C. P. Falshaw. Isolation of desacetylvindoline from Catharanthus roseus. Naturwissenschaften 1965; 52: 132.

    Article  Google Scholar 

  15. Bhakuni, D. S. and R. S. Kapil. Monoterpene glycosides from Vinca rosea. Indian J Chem 1972; 10: 454.

    CAS  Google Scholar 

  16. Svoboda, G. H. and A. J. Barnes Jr. Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don) XXXIV. Vinaspine, vincathicine, rovidine, desacetyl vlb and vinphamine. J Pharm Sci 1964; 53: 1227.

    Article  PubMed  CAS  Google Scholar 

  17. Svoboda, G. H., A. T. Oliver and D. R. Bedwell. Alkaloids of Vinca rosea (Catharanthus roseus). XIX. Extraction and characterization of root alkaloids. Lloydia 1963; 26: 141.

    CAS  Google Scholar 

  18. Svoboda, G. H., M. Gorman and R. H. Tust. Alkaloids of Vinca rosea (Catharanthus roseus). XXV. Lochrovine, perimivine, vincoline, lochrovidine, lochrovicine and vincolidine. Lloydia 1964; 27: 203.

    CAS  Google Scholar 

  19. Johnson, I. S., H. F. Wright, G. H. Svoboda and J. Vlantis. Antitumor principles derived from Vinca rosea. 1. Vincaleukoblastine and leurosine. Cancer Res 1960; 20: 1016.

    PubMed  CAS  Google Scholar 

  20. Svoboda, G. H. A note on several new alkaloids from Vinca rosea. I. Leurosine, virosine, perivine. J Amer Pharm Ass Sci Ed 1958; 47: 834.

    Article  CAS  Google Scholar 

  21. Svoboda, G. H., M. Gorman, N. Neuss and A. J. Barnes Jr. Alkaloids of Vinca rosea (Catharanthus roseus). VIII. Preparation and characterization of new minor alkaloids. J Pharm Sci 1961; 50: 409.

    Article  CAS  Google Scholar 

  22. Steenis-Kruseman, M. J. Van. Select Indonesian medicinal plants. Organiz Sci Res Indonesia Bull 1953; 18: 1.

    Google Scholar 

  23. Farnsworth, N. R. The pharmacognosy of the periwinkles: Vinca and Catharanthus. Lloydia 1961; 24(3): 105–138.

    CAS  Google Scholar 

  24. Oliver-Bever, B. Selecting local drug plants in Nigeria. Botanical and Chemical relationship in three families. Q J Crude Drug Res 1968; 8(2): 1194.

    Google Scholar 

  25. ANON, Description of the Philippines. Part I., Bureau of Public Printing, Manila, 1903.

    Google Scholar 

  26. Chopra, I. C., K. S. Jamwal, C. L. Chopra, C. P. N. Nair and P. P. Pillay. Preliminary pharmacological investigations of total alkaloids of Lochnera rosea (Rattonjot). Indian J Med Res 1959; 47: 40.

    Google Scholar 

  27. Moza, B. K. and J. Trojanek. New alkaloids from Catharanthus roseus. Chem Ind (London) 1962; 1962: 1425.

    Google Scholar 

  28. Moza, B. K. and J. Trojanek. Catharosine, a new alkaloid from Catharanthus roseus. Chem Ind (London) 1965; 1965: 1260.

    Google Scholar 

  29. Webb, L. J. Guide to the medicinal and poisonous plants of Queensland. CSIR Bull 232, Melbourne, 1948.

    Google Scholar 

  30. Thorp, R. H. and T. R. Watson. A survey of the occurrence of cardio-active constituents in plants growing wild in Australia. 1. Families Apocynaceae and Asclepiadaceae. Aust J Exp Biol 1953; 31: 529.

    Article  CAS  Google Scholar 

  31. Neogi, N. C. and M. C. Bhatia. Biological investigation of Vinca rosea. Indian J Pharmacy 1956; 18: 73.

    CAS  Google Scholar 

  32. Paris, R. R. and H. Moyse-Mignon. A sympatholytic Apocynaceae, Vinca rosea. CR Acad Sci 1953; 240: 1993.

    Google Scholar 

  33. Pernet, M., G. Meyer, J. M. Bosser and G. Ratsiandavana. The Catharanthus of Madagascar. CR Acad Sci 1956; 243: 1352.

    Google Scholar 

  34. Svoboda, G. H., N. Neuss and M. Gorman. Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don). V. Preparation and characterization of alkaloids. J Amer PharmAss Sci Ed 1959; 48: 659–666.

    Article  CAS  Google Scholar 

  35. Shorti, D. S., M. Kelkar, V. K. Deshmukh and R. Aiman. Investigation of the hyperglycemic properties of Vinca rosea, Cassia auriculata and Eugenia jambolana. Indian J Med Res 1963; 51(3): 464–467.

    Google Scholar 

  36. Willaman, J. J. and H. L. Li. Alkaloidbearing plants and their contained alkaloids, 1957–1968. Lloydia 1970; 335: 1–286.

    Google Scholar 

  37. Tangkongchitr, U. Extraction of organic compounds from Vinca rosea Linn. Master Thesis 1973; 43pp.

    Google Scholar 

  38. Rizk, A. F. M. The Phytochemistry of the Flora of Qatar, Scientific and Applied Research Centre, University of Qatar, Kingsprint, Richmond, UK 1986; 582pp.

    Google Scholar 

  39. Arfmann, H. A., W. Kohl and V. Wray. Effect of 5-azacytidine on the formation of secondary metabolites in Catharanthus roseus cell suspension cultures. Z Naturforsch Ser C 1985; 40: 21–25.

    Google Scholar 

  40. ANON. Ayurvedic drug to fight cancer. Probe 1985; 24(4): 234.

    Google Scholar 

  41. Grill, E., E. L. Winnacker and M. H. Zenk. Phytochelatins: The principal heavy-metal complexing peptides of higher plants. Science 1985; 230(4726): 674–676.

    Article  PubMed  CAS  Google Scholar 

  42. Atta-ur-Rahman, I. Ali and M. I. Chaudhary. Bannucine—A new dihydroindole alkaloid from Catharanthus roseus (L) G. Don. J Chem Soc Perkin Trans I 1986(6); 923–926.

    Article  Google Scholar 

  43. Atta-ur-Rahman, M. Alam, I. Ali, Habib-ur-Rehman and I. Hag. Leurosine: A new binary indole alkaloid from Catharanthus roseus. J Chem Soc Perkin Trans I 1988(8); 2175–2178.

    Google Scholar 

  44. Fahn, W., V. Kaiser, H. Schubel, J. Stockigt and B. Daniel. Catharanthus roseus enzyme mediated synthesis of 3hydroxyvoafrine A and B — A simple route to the voafrines. Phytochemistry 1990; 29(1): 127–133.

    Article  CAS  Google Scholar 

  45. Wissing, J. B. and H. Behrbohm. Diacylglycerol pyrophosphate, a novel phospholipid compound. Febs Lett 1993; 315(1): 95–99.

    Article  PubMed  CAS  Google Scholar 

  46. Fujioka, S., T. Inoue, S. Takatsuto, T. Yanagisawa, T. Yokota and A. Sakurai. Identification of a new brassinosteroid, cathasterone, in cultured cells of Catharanthus roseus as a biosynthetic precursor of teasterone. Biosci Biotech Biochem 1995; 59(8): 1543–1547.

    Article  CAS  Google Scholar 

  47. Neuss, N., A. J. Barnes and L. L. Huckstep. Vinca alkaloids. XXXV. Desacetoxyvinblastine: A new minor alkaloid from Vincarosea(Catharanthus roseus). Experientia 1975; 31: 18.

    Article  PubMed  CAS  Google Scholar 

  48. Bhakuni, D. S., P. P. Joshi, H. Uprety and R. S. Kapil. Roseoside — A C-13 glycoside from Vinca rosea. Phytochemistry 1974; 13: 2541–2543.

    Article  CAS  Google Scholar 

  49. Guarnaccia, R., L. Botta and C. J. Coscia. Biosynthesis of acdic iridoid monoterpene glucosides in Vincarosea. Amer Chem Soc 1974; 96: 7079.

    Article  CAS  Google Scholar 

  50. Jones, W. E. and G. J. Cullinan. Vincadioline. Patent-US-3,887,565 1975: 4 pp.

    Google Scholar 

  51. Scott, A. I and S. L. Lee. Biosynthesis of the indole alkaloids. A cell-free systern from Catharanthus roseus. J Amer Chem Soc 1975; 97: 6906.

    Article  CAS  Google Scholar 

  52. Jovanovics, K., K. Szasz, G. Fekete, E. Bittner, E. Dezseri and J. Eles. Isolation of vincristine and n-demethylvinblastine from Vinca rosea. Patent-Ger Offen-2,259,388 1974.

    Google Scholar 

  53. Aynilian, G. H., S. G. Weiss, G. A. Cordell, D. J. Abraham, F. A. Crane and N. R. Farnsworth. Catharanthus alkaloids. XXIX. Isolation and structure elucidation of vincoline. J Pharm Sci 1974; 63(4): 536–538.

    Article  PubMed  CAS  Google Scholar 

  54. Tafur, S. S., W. E. Jones, D. E. Dorman, E. E. Logsdon and G. H. Svoboda. Alkaloids of Vinca rosea (Catharanthus roseus). XXXVI. Isolation and characterization of new dimeric alkaloids. J Pharm Sci 1975; 64: 1953.

    Article  PubMed  CAS  Google Scholar 

  55. Weiss, S. G. Antitumor principles of Linum album and Catharanthus roseus. Diss Abstr Int 1974; 35: 2669.

    Google Scholar 

  56. Luu, C. Notes on the traditional pharmacopoeia of French Guyana. Plant Med Phytother 1975; 9: 125–135.

    Google Scholar 

  57. Neuss, N. and A. J. Barnes. 4-Deacetoxyvinblastine. Patent-US-3,954,773 1976.

    Google Scholar 

  58. Carew, D. P. and R. J. Krueger. Anthocyanidins of Catharanthus roseus callus cultures. Phytochemistry 1976; 15: 442A.

    Google Scholar 

  59. Tafur, S. S. 4-Desacetoxy-3-hydroxyvinblastine. Patent-US-3,944,554 1976.

    Google Scholar 

  60. Siegel, R. K. Herbal intoxication. Psychoactive effects from herbal cigarettes, tea, and capsules. J Amer Med Assoc 1976; 236(5): 473–476.

    Article  CAS  Google Scholar 

  61. Atta-ur-Rahman, I. Ali and M. Bashir. Isolation of rhazimol from the leaves of Catharanthus roseus. J Nat Prod 1984; 47(2): 389.

    Article  CAS  Google Scholar 

  62. Atta-ur-Rahman. Some approaches to the study of indigenous medicinal plants. Bull Islamic Med 1982; 2: 562–568.

    Google Scholar 

  63. Hsu, F. L. and J T. Cheng. Investigation in rats of the antihyperglycaemic effect of plant extracts used in Taiwan for the treatment of diabetes mellitus. Phytother Res 1992; 6(2): 108–111.

    Article  Google Scholar 

  64. Brandao, M., M. Botelho and E. Krettli. Antimalarial experimental chemotherapy using natural products. Cienc Cult 1985; 37(7): 1152–1163.

    Google Scholar 

  65. Chattopadhay, R. R., S. K. Sarkar, S. Ganguly, R. N. Banerjee and T. K. Basu. Effect of extract of leaves of Vincarosea Linn. on glucose utilization and glycogen deposition by isolated rat hemidiaphragm. Indian J Physiol Pharmacol 1992; 36(2): 137–138.

    Google Scholar 

  66. Schripsema, J. and R. Verpoorte. Regulation of indole alkaloid biosynthesis in Catharanthus roseus cell suspension cultures, investigated with 1H-NMR. Planta Med Suppl 1992; 58(1): A608.

    Article  Google Scholar 

  67. Chattopadhyay, R. R., R. N. Banerjee, S. K. Sarkar, S. Ganguly and T. K. Basu. Anti-inflammatory and acute toxicity studies with the leaves of Vinca rosea Linn. in experimental animals. Indian J Physiol Pharmacol 1992; 36(4): 291–292.

    PubMed  CAS  Google Scholar 

  68. Duperon, P., J. P. Allais and A. Dupaix. Comparison of the sterol content of tonoplast and microsomal fractions from Catharanthus roseus suspensioncultured cells. Plant Physiol Biochem (Paris) 1992; 30(4): 495–498.

    CAS  Google Scholar 

  69. Petiard, V., D. Courtois, F. Gueritte, N. Langlois and B. Mompon. New alkaloids in plant tissue cultures. Proc 5th Intl Cong Plant Tissue & Cell Culture 1982; 309–310.

    Google Scholar 

  70. Kutney, J. P. Studies in plant tissue culture — potentially important sources of clinically important anti-cancer agents. Proc FECS Third Int Conference on Chemistry and Biotechnology of Biologically Active Natural Products, Vol 1 PP168–179, VCH Publisher Inc NY, NY 1973; 1: 168–179.

    Google Scholar 

  71. Perdue Jr, R. E. Cell Culture. 1. Role in discovery of antitumor agents from higher plants. J Nat Prod 1982; 45(4): 418–426.

    Article  PubMed  CAS  Google Scholar 

  72. Ali, I. The alkaloids in flowers of Catharanthus roseus (L) G. Don. Gomal Univ J Res 1990; 10(1): 27–31.

    CAS  Google Scholar 

  73. Lin, C. C. Crude drugs used for the treatment of diabetes mellitus in Taiwan. Amer J Chin Med 1992; 20(3/4): 269–279.

    Article  CAS  Google Scholar 

  74. Tabata, H. Manufacture of tabersonine derivatives by plant tissue culture. Patent-Japan Kokai Tokkyo Koho-05 1993; 219,975: 5pp.

    Google Scholar 

  75. Hars, Y. and F. Ito. Manufacture of indole alkaloids with plant tissue or organ culture. Patent-Japan Kokai Tokkyo Koho-04 1992; 91–785: 7pp.

    Google Scholar 

  76. Kulkarni, R. and N. Ravindra. Resistance to Pythium aphanidermatum in diploids and induced autotetraploids of Catharanthus roseus. Planta Med 1988; 54(4): 356–359.

    Article  PubMed  CAS  Google Scholar 

  77. De Luca, V., N. Brisson, J. Balsevich and W. G. W. Kurz. Regulation of vindoline biosynthesis in Catharanthus roseus: Molecular cloning of the first and last steps in biosynthesis. Primary and Secondary Metabolism of Plant Cell Cultures II. 1989; 154–161.

    Article  Google Scholar 

  78. Zamora-Martinez, M. C. and C. N. P. Pola. Medicinal plants used in some rural populations of Oaxaca, Puebla and Veracruz, Mexico. J Ethnopharmacol 1992; 35(3) 229–257.

    Article  PubMed  CAS  Google Scholar 

  79. Nagy-Turak, A. and Z. Vegh. Extraction and in situ densitometric determination of alkaloids from Catharanthus roseus by means of overpressured layer chromatography on amino-bonded silica layers. I. Optimization and validation of the separation system. J Chromatogr A 1994; 668(2): 501–507.

    Article  CAS  Google Scholar 

  80. Islas, I., V. M. Loyola-Vargas and M. De Lourdes Miranda-Ham. Tryptophan decarboxylase activity in transformed roots from Catharanthus roseus and its relationship to tryptamine, ajmalicine and catharanthine accumulation during the culture cycle. In Vitro Cell Dev Biol 1994; 30P: 81–83.

    CAS  Google Scholar 

  81. Benjamin, B. D., S. M. Kelkar, M. S. Pote, G. S. Kakli, A. T. Sipahimalani and M. R. Heble. Catharanthus roseus cell cultures: Growth, alkaloid synthesis and antidiabetic activity. Phytother Res 1994; 8(3): 185–186.

    Article  CAS  Google Scholar 

  82. Zhou, X. H., R. Minocha and S. C. Minocha. Physiological response of suspension cultures of Catharanthus roseus to aluminum: Changes in polyamines and inorganic ions. J Plant Physiol 1995; 145(3): 277–284.

    Article  CAS  Google Scholar 

  83. Holdsworth, D. K. Traditional medicinal plants of Rarotonga, Cook Islands Part 1.Int J Crude Drug Res 1990; 28(3): 209–218.

    Google Scholar 

  84. Kamata, H. Production of vinca-alkaloid. Patent-Japan Kokai Tokkyo Koho-61 1986; 274,694: 6 pp.

    Google Scholar 

  85. Maikhuri, R. K. and A. K. Gangwar. Ethnobiological notes on the Khasi and Garo tribes of Meghalaya, Northeast India. Econ Bot 1993; 47(4): 345–357.

    Article  Google Scholar 

  86. Stockigt, J., H. P. Husson, C. Kan-Fan and M. H. Zenk. Cathenamine, a central intermediate in the cell free biosynthesis of ajmalicine and related indole alkaloids. Chem Commun 1977; 164–166.

    Google Scholar 

  87. Cuellar, A. Catharanthus roseus alkaloids. The structure of vincubine. Rev Cubana Farm 1976; 10: 19.

    CAS  Google Scholar 

  88. Scott, A. I., S. L. Lee and W. Wan. Indole alkaloid biosynthesis: Partial purification of “ajmalicine synthetase” from Catharanthus roseus tissue cultures. Heterocycles 1977; 6: 1552.

    Article  Google Scholar 

  89. Morton, J. F. Medicinal and other plants used by people on North Caicos (Turks and Caicos Islands, West Indies). J Crude Drug Res 1977; 15: 1–24.

    Google Scholar 

  90. Amico, A. Medicinal plants of Southern Zambesia. Fitoterapia 1977; 48: 101–139.

    CAS  Google Scholar 

  91. Treimer, J. F. and M. H. Zenk. Enzymic synthesis of corynanthe-type alkaloids in cell cultures of Catharanthus roseus: Quantation by radioimmunoassay. Phytochemistry 1978; 17: 227–231.

    Article  Google Scholar 

  92. Sarin, J. P. S., R. C. Nandi, R. S. Kapil and N. M. Khanna. Estimation of ajmalicine in Catharanthus roseus. Indian J Pharmacy 1977; 39: 62.

    CAS  Google Scholar 

  93. Deus, B. Cell cultures of Catharanthus roseus. Production of Natural Compounds by Cell Culture Methods. Proc Int Symp Plant Cell Cult, Ges Strahlen Umweltforsch, Munich (Al Fermann, AW, Reinhard, EC, EDS) 1978; 118.

    Google Scholar 

  94. De Luca, V., J. Balsevich and M. G. W. Kurz. Purification and properties of deacetylvindoline acetyltransferase from Catharanthus roseus. Abstr Internat Res Cong Nat Prod Coll Pharm Univ, Chapel Hill NC July 7–12,1985; Abstr-103.

    Google Scholar 

  95. Bandyopadhyay, M. N., B. B. Mukheruee and S. N. Ganguly. IAA from the pollen grains and style stigma segments of Catharanthus roseus (Linn.) G. Don. Physiol Sex Reprod Flowering Plants Int Symp ist 1976 1978; 102–104.

    Google Scholar 

  96. Atta-ur-Rahman, S. Malik and K. Albert. Structural studies on vindolinine. Z Naturforsch Ser B 1986; 41(3): 386–392.

    Google Scholar 

  97. Dolya, V. S., N. V. Svinidze, Y. I. Kornievskii and T. R. Gokitidze. Fatty oils of four plants of the Subtropics. Farm Zh (Kiev) 1985(2); 76–77.

    Google Scholar 

  98. Kutney, J. P. Studies on plant tissue cultures. Heterocycles 1981; 15: 1405–1431.

    Article  CAS  Google Scholar 

  99. Schiel, O. and J. Berlin. Geranio1–10hydroxylase of Catharanthus roseus and its correlation with indole alkaloid biosynthesis. Planta Med 1986; 1986(1): 422A.

    Article  Google Scholar 

  100. Atta-ur-Rahman, S. Hasan and M. R. Qulbi. Beta-carboline from Catharanthus roseus. Planta Med 1985; 1985(3): 287.

    Google Scholar 

  101. Margo, G., H. Bouyssou and B. M. Mal. Vacuolar efflux of malate and its influence on nitrate accumulation in Catharanthus roseus cells. Plant Sci 1985; 39(2): 97–103.

    Article  Google Scholar 

  102. Atta-ur-Rahman and I. Ali. 13-C NMR Spectroscopic studies on gomaline and rosamine. Fitoterapia 1986; 57(6): 438–440.

    CAS  Google Scholar 

  103. Atta-ur-Rahman, I. Ali and M. I. Chaudhry. Isolation and 13-C-NMR studies on cathovaline, an alkaloid from the leaves of Catharanthus roseus. Planta Med 1985; 1985(5): 447–448.

    Google Scholar 

  104. Schripsema, J., T. A. Van Beek, R. Verpoorte, C. Erkelens, P. Perera and C. Tibell. A reinvestigation of the stereochemistry of tubotaiwine using NMR spectroscopy. J Nat Prod 1987; 50(1): 89–101.

    Article  CAS  Google Scholar 

  105. Daniel, M. and S. D. Sabnis. Chemotaxonomical studies on Apocynaceae. Indian J Exp Biol 1978; 16(4): 512–513.

    CAS  Google Scholar 

  106. Ashihara, H. changes in fructose-2,6biphosphate level during the growth of suspension cultured cells of Catharanthus roseus. Z Naturforsch Ser C 1986; 41(5/6): 529–531.

    CAS  Google Scholar 

  107. Garg, S. P., M. R. K. Sherwani, A. Arora, R. Agarwal and M. Ahmad. Ricinoleic acid in Vinca rosea seed oil. J Oil Technol Ass India (Bombay) 1987; 19(3): 63–64.

    CAS  Google Scholar 

  108. Rai, M. K. and S. Upadhyay. Screening of medicinal plants of Chhindwara district against Trichophyton mentagrophytes: A casual organism of Tinea pedis. Hindustan Antibiot Bull 1988; 30(1/2): 33–36.

    PubMed  CAS  Google Scholar 

  109. De Mello, J. F. Plants in traditional medicine in Brazil. J Ethnopharmacol 1980; 2(1): 49–55.

    Article  PubMed  Google Scholar 

  110. Chattopadhyay, S. P. and P. K. Das. Evaluation of Vinca rosea for the treatment of warts. Indian J Dermatol Venereol Leprol 1990; 56(2): 107–108.

    Google Scholar 

  111. Johns, T., J. O. Kokwaro and E. K. Kimanani. Herbal remedies of the Luo of Siaya District, Kenya. Establishing quantitative criteria for consensus. Econ Bot 1990; 44(3): 369–381.

    Article  Google Scholar 

  112. Swanston-Flatt, S. K., C. Day, P. R. Flatt, B. J. Gould and C. J. Bailey. Glycaemia effects of traditional European plant treatments for diabetes studies in normal and streptozotocin diabetic mice. Diabetes Res 1989; 10(2): 69–73.

    PubMed  CAS  Google Scholar 

  113. Pennings, E. J. M., R. Verpoorte, O. J. M. Goddijn and J. H. C. Hoge. Purification of trypophan decarboxylase from a Catharanthus roseus cell suspension culture. J Chromatogr 1989; 483(1): 311–318.

    CAS  Google Scholar 

  114. Gomez, G. A. and J. E. Sokal. Use of vinblastine in the terminal phase of chronic myelocytic leukemia. Cancer Treat Rep 1979; 63: 1385–1387.

    PubMed  CAS  Google Scholar 

  115. Singh, J., K. L. Handa, P. R. Rao and C. K. Atal. Recovery of ajmalicine (raubasine) from Vinca rosea. Res Ind 1978; 23: 166–167.

    CAS  Google Scholar 

  116. Maccarthy, J. J. and P. K. Stumpf. Fatty acid composition and biosynthesis on cell suspension cultures of Glycine max, Catharanthus roseus and Nicotiana tabacum. Planta (Berla) 1980; 147: 384–388.

    Article  CAS  Google Scholar 

  117. Mizukami, H., H. Norlov, S. L. Lee and A. I. Scott. Purification and properties of strictosidine synthetase (an enzyme condensing tryptamine and secologanin) from Catharanthus roseus cultured cells. Biochemistry 1979; 18: 3760–3763.

    Article  PubMed  CAS  Google Scholar 

  118. Anon. Isolating alkaloid compounds from Vinca rosea. Patent-Belg-867,670 1978.

    Google Scholar 

  119. Madati, P. J., H. A. Pazi and A. Ernest. Phytochemical investigation of Catharanthus roseus growing wildly in East Africa. J Afr Med Pl 1979; 2: 1.

    Google Scholar 

  120. Barrois, V. and N. R. Farnsworth. The value of plants indicated by traditional medicine in cancer therapy. WHO, Geneva Nov. 13–17, 1978.

    Google Scholar 

  121. El-Merzabani, M. M., A. A. El-Aaser, A. K. El-Duweini and A. M. El-Masry. A bioassay of antimitotic alkaloids of Catharanthus roseus. Planta Med 1979; 36: 87–90.

    Article  PubMed  CAS  Google Scholar 

  122. El-Merzabani, M. M., A. A. El-Aaser, M. A. Attla, A. K. El-Duweini and A. M. Ghazal. Screening system for Egyptian plants with potential anti-tumor activity. Planta Med 1979; 36: 150–155.

    Article  PubMed  CAS  Google Scholar 

  123. Wahl, J. Airlift fermenter for growing plant cell cultures. Git Fachz Lab 1979; 23: 169–171.

    CAS  Google Scholar 

  124. Schwenn, J. D., H. El-Shagi, A. Kemena and E. Petrak. On the role of s:sulfotransferases in assimilatory sulfate reduction by plant suspension cultures. Planta 1979; 144: 419–425.

    Article  CAS  Google Scholar 

  125. Ayensu, E. S. Medicinal plants of the West Indies. Unpublished Manuscript 1978; 110pp.

    Google Scholar 

  126. Chauhan, S., S. Agrawal, R. Mathur and R. K. Gupta. Phosphatase activity in testis and prostate of rats treated with embelin and Vinca rosea extract. Experientia 1979; 35: 1183–1185.

    Article  PubMed  CAS  Google Scholar 

  127. Virmani, O. P., G. N. Srivastava and P. Singh. Catharanthus roseus - The tropical periwinkle. Indian Drugs 1978; 15: 231–252.

    CAS  Google Scholar 

  128. Asthana, R. B. and M. K. Misra. Orally effective hypoglycemic agent from Vinca rosea. Indian J Biochem Biophys 1979; 16: 30.

    Google Scholar 

  129. Erdelsky, K. and L. Holickova. Cultivation of plant tissue culture of Vinca rosea L. and its alkaloid contents. Acta Fac Rerum Nat Univ Comenianae Physiol Plant 1978(15); 1–10.

    Google Scholar 

  130. Rueffer, M., C. Kan-Fan, H. P. Husson, J. Stockigt and M. H. Zenk. 4,21Dehydrogeissoschizine, an intermediate in heteroyohimbine alkaloid biosynthesis. Chem Commun 1979; 1016–1018.

    Google Scholar 

  131. El-Sayed, A., G. A. Handy and G. A. Cordell. Catharanthus alkaloids. XXXIII. 21′-Oxoleurosine from Catharanthus roseus (Apocynaceae). J Nat Prod 1980; 43: 157–161.

    Article  PubMed  CAS  Google Scholar 

  132. Tanaka, M. and T. Uchida. Heterogeneity of hydroxypyroline-containing glycoproteins in protoplasts from a Vinca rosea suspension culture. Plant Cell Physiol 1979; 20: 1295–1306.

    CAS  Google Scholar 

  133. Misawa, M. Production of natural substances by plant cell cultures described in Japanese patents. Plant Tissue Culture ITS Bio-Technol Appl Int Cong 1976 1977; 17–26.

    Article  Google Scholar 

  134. Farnsworth, N. R. and C. J. Kaas. An approach utilizing information from traditional medicine to identify tumorinhibiting plants. J Ethnopharmacol 1981; 3(1): 85–99.

    Article  PubMed  CAS  Google Scholar 

  135. El-Sayed, A., G. H. Handy and G. A. Cordell. Further dimeric indole alkaloids from Catharanthus roseus (L.) G. Don (Apocynaceae). J Nat Prod 1979; 42: 687D.

    Google Scholar 

  136. Kohl, W., H. Vogelmann and G. Hofle. Alkaloids from Catharanthus roseus tissue cultures. Planta Med 1980; 39: 283–284.

    Google Scholar 

  137. Kurz, W. G. W., K. B. Chatson, F. Constabel, J. P. Kutney, L. S. L. Choi, P. Kolodziejczyk, S. K. Sleigh and K. L. Stuart. The production of catharanthine and other indole alkaloids by cell suspension cultures of Catharanthus roseus. Planta Med 1980; 39: 284A.

    Google Scholar 

  138. Cantoria, M. Aromatic and medicinal herbs of the Philippines. Q J Crude Drug Res 1979; 14: 97–128.

    Google Scholar 

  139. Hemscheidt, T. and M. H. Zenk. Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures. Febs Lett 1980; 110: 187–191.

    Article  PubMed  CAS  Google Scholar 

  140. Scott, A. I., H. Mizukami and S. L. Lee. Characterization of a 5-methyltrypophan resistant strain of Catharanthus roseus cultured cells. Phytochemistry 1979; 18: 795–798.

    Article  CAS  Google Scholar 

  141. Anon. Antifertility studies on plants. Annual Report of the Director General — Indian Council of Medical Research 1979–1980 1979; 71–72.

    Google Scholar 

  142. Ali, M. E., N. Huq, A. K. M. M. Rahman, A. Moitra and A. Rahman. Chemical investigations on Vincarosea Linn. (Nayantara). Bangladesh J Sci Ind Res 1979; 14: 354–358.

    CAS  Google Scholar 

  143. Pardasani, K. M., S. Singh and J. P. S. Sarin. Chromatographic estimation of vincaleukoblastine in Catharanthus roseus Linn. Indian J Pharm Sci 1979; 41: 207–213.

    CAS  Google Scholar 

  144. Kurz, W. G. W., K. B. Chatson, F. Constabel, J. P. Kutney, L. S. L. Choi, P. Kolodziejczyk, S. K. Sleigh, K. I. Stuart and B. R. Worth. Alkaloid production in Catharanthus roseus cell cultures: Initial studies on cell lines and their alkaloid content. Phytochemistry 1980; 19: 2583–2587.

    Article  CAS  Google Scholar 

  145. El-Sayed, A. and G. A. Cordell. Catharanthus alkaloids. XXXIV. Catharanthamine, a new antitumor bisindole alkaloid from Catharanthus roseus. J Nat Prod 1981; 44: 289–293.

    Article  PubMed  CAS  Google Scholar 

  146. Mukhopadhyay, S. and G. A. Cordell. Catharanthus alkaloids. XXXVI. Isolation of vincaleukoblastine (VLB) and periformyline from Catharanthus trichophyllus and pericyclivine from Catharanthus roseus. J Nat Prod 1981; 44: 335–339.

    Article  PubMed  CAS  Google Scholar 

  147. Hutchinson, C. R. Biosynthetic studies of antitumor indole alkaloids. Annu Proc Phytochem Soc Eur 1980; 17: 143–158.

    CAS  Google Scholar 

  148. Meksongsee, L., Y. Jiamchaisri, P. Sinchaisri and L. Kasamsuksakan. Effects of some Thai medicinal plants and spices on the alkylating activity of ethyl methane sulfonate. Abstr 4th Asian Sym Med Plants Spices Bangkok, Thailand Sept. 15–19, 1980; 1980: 118.

    Google Scholar 

  149. Mukhopadhyay, S. and G. A. Cordell. Catharanthus alkaloids. XXXV. Isolation of leurosidine-n’-b-oxide from Catharanthus roseus. J Nat Prod 1981; 44: 611–613.

    Article  PubMed  CAS  Google Scholar 

  150. Khan, N. and D. P. Chakraborty. Alpha amyrin acetate from Cat haranthus roseus Linn. J Indian Chem Soc 1981; 58: 628–629.

    CAS  Google Scholar 

  151. Kohl, W., B. Witte and G. Hofle. Alkaloids from Catharanthus roseus tissue cultures. II. Z Naturforsch Ser B 1981; 36: 1153–1162.

    Google Scholar 

  152. Tanaka, M., H. Shibata and T. Uchida. A new prolyl hydroxylase acting on poly-l-proline, from suspension cultured cells of Vinca rosea. Biochim Biophys Acta 1980; 616: 188–198.

    Article  PubMed  CAS  Google Scholar 

  153. Ghosh, R. K. and I. Gupta. Effect of Vinca rosea and Ficus racemososus on hyperglycaemia in rats. Indian J Anim Health 1980; 19: 145–148.

    Google Scholar 

  154. Nguyen, Van Dan. List of simple drugs and medicinal plants of value in Vietnam. Proc Seminar of the Use of Medicinal Plants in Healthcare, Tokyo 13–17 September 1977, WHO Regional Office Manila, 65–83.

    Google Scholar 

  155. Petiard, V., F. Gueritte, N. Langolis and P. Potier. Presence of (-) tabersonine in a tissue culture strain of Catharanthus roseus G. Don. Physiol Veg 1980; 18: 711–720.

    CAS  Google Scholar 

  156. Meisner, J., M. Weissenberg, D. Palevitch and N. Aharonson. Phago- deterrency induced by leaves and leaf extracts of Catharanthus roseus in the larva of Spodoptera littoralis. J Econ Entomol 1981; 74: 131–135.

    Google Scholar 

  157. Milo, J. Flower color inheritance and shoot and ajmalicine yield components in successive developmental stages of pure lines and F-1 hybrids in Catharanthus roseus (L.) G. Don. Thesis-MS-Hebrew University 1981; 1981: 74 pp.

    Google Scholar 

  158. Davey, J. E., J. Van Staden and G. T. N. De Leeuw. Endogenous cytokinin levels and development of flower virescence in Catharanthus roseus infected with mycoplasmas. Physiol Plant Pathol 1981; 19: 193–200.

    CAS  Google Scholar 

  159. Verzele, M., L. De Taeye, J. Van Dyck, G. De Decker and C. De Pauw. High-performance liquid chromatography of Vinca rosea alkaloids and the correlation of plate height and molecular weight. J Chromatogr 1981; 214: 95–99.

    Article  CAS  Google Scholar 

  160. Lim-Sylianco, C. Y. and F. Blanco. Antimutagenic effects of some anticancer agents. Bull Philipp Biochem Soc 1981; 4(1): 1–7.

    CAS  Google Scholar 

  161. Shimazaki, A., F. Hirose and H. Ashihara. Changes in adenine nucleotide levels and adenine salvage during the growth of Vinca rosea cells suspension culture. Z Pflanzenphysiol 1982; 106: 191–198.

    CAS  Google Scholar 

  162. Kanamori-Fukuda, I., H. Ashihara and A. Komamine. Pyrimidine nucleotide biosynthesis in Vinca rosea cells: Changes in the activity of the de novo and salvage pathways during growth in a suspension culture. J Exp Bot 1981; 32(126): 69–78.

    Article  CAS  Google Scholar 

  163. Chile, S. K., M. Saraf and A. K. Barde. Efficacy of Vinca rosea extract against human pathogenic strains of Trichophyton rubrum Sab. Indian Drugs Pharm Ind 1981; 16(1): 31–33.

    Google Scholar 

  164. Atta-Ur-Rahman, M. Bashir, S. Kaleem and T. Fatima. 16-Epi-19-svindolinine, an indoline alkaloid from Catharanthus roseus. Phytochemistry 1983; 22(4): 1021–1023.

    Article  CAS  Google Scholar 

  165. Gueritte, F., N. Langlois and V. Petiard. Secondary metabolites isolated from a tissue culture of Catharan- thus roseus. J Nat Prod 1983; 46(1): 144–148.

    Article  CAS  Google Scholar 

  166. Sukumar, K. and Z. Osmani. Insect sterilants from Catharanthus roseus. Curr Sci 1981; 50: 552–553.

    Google Scholar 

  167. Kohl, W., B. Witte and G. Hofle. Quantitative and qualitative HPLCanalysis of indole alkaloids from Catharanthus roseus cell cultures. Planta Med 1983; 47(3): 177–182.

    Article  PubMed  CAS  Google Scholar 

  168. Constabel, F., S. Rambold, K. B. Chatson, W. G. M. Kurz and J. P. Kutney. Alkaloid production in Catharanthus roseus (L.) G. Don. VI. Variation in alkaloid spectra of cell lines derived from one single leaf. Plant Cell Rep 1981; 1(1): 3–5.

    Article  CAS  Google Scholar 

  169. Kohl, W., B. Witte and G. Hofle. Alkaloids from Catharanthus roseus tissue cultures. 3. Z Naturforsch Ser B 1982; 37: 1346–1351.

    Google Scholar 

  170. Mukhopadhyay, S., A. El-Sayed, G. A. Handy and G. A. Cordell Catharanthus alkaloids. XXXVII. 16-Epi-z-isositsirikine, a monomeric indole alkaloid with antineoplastic activity from Catharanthus roseus and Rhazya stricta. J Nat Prod 1983; 46(3): 409–413.

    Article  PubMed  CAS  Google Scholar 

  171. Rojas, N. M. and A. Cuellar. Catharanthus roseus G. Don. 1. Microbiological study of its alkaloids. First Latin American & Caribbean Symposium on Pharmacologically Active Natural Products, Cuba 1982 UNESCO 1982; 194.

    Google Scholar 

  172. Takeuchi, Y. and A. Komamine. Turnover of cell wall polysaccharides of a Vinca rosea suspension culture. I. Synthesis and degradation of cell wall components. Physiol Plant 1980; 48: 271–277.

    Article  CAS  Google Scholar 

  173. Ross, S. A., S. E. Megalla, D. W. Bishay and A. H. Awad. Studies for determining antibiotic substances in some Egyptian plants. Part 1. Screening for antimicrobial activity. Fitoterapia 1980; 51: 303–308.

    CAS  Google Scholar 

  174. Morrison, E. Y. S. A. and M. West. A preliminary study of the effects of some West Indian medicinal plants on blood sugar levels in the dog. West Indian Med J 1982;31: 194–197.

    PubMed  CAS  Google Scholar 

  175. Rahman, A. U. and M. Bashir. Isolation of new alkaloids from Catharan-thus roseus. Planta Med 1983; 49(2): 124–125.

    Google Scholar 

  176. Hirose, F. and H. Ashihara. Adenine phosphoribosyltransferase activity in mitochondria of Catharanthus roseus cells. Z Naturforsch Ser C 1982; 37(11/12): 1288–1289.

    Google Scholar 

  177. Treimer, J. F. and M. H. Zenk. Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation. Eur J Biochem 1979; 101: 225–233.

    Article  PubMed  CAS  Google Scholar 

  178. Stoeckigt, J. and M. H. Zenk. Strictosidine (isovincoside): The key intermediate in the biosynthesis of monoterpenoid indole alkaloids. Chem Commun 1977; 1977(18): 646–648.

    Google Scholar 

  179. Simonds, R., A. De Bruyn, L. De Taeye, M. Verzele and C. De Pauw. Ndeformyl vincristine: A bisalkaloid from Catharanthus roseus. Planta Med 1984; 1984(3): 274–276.

    Article  Google Scholar 

  180. Wink, M. Chemical defense of lupins. Mollusc-repellent properties of quinolizidine alkaloids. Z Naturforsch Ser C 1984; 39(6): 553–558.

    Google Scholar 

  181. Atta-Ur-Rahman, I. Ali, M. Bashir and M. I. Choudhary. Isolation and structure of rosamine — A new pseudoindoxyl alkaloid from Catharanthus roseus. Z Naturforsch Ser B 1984; 39(9): 1292–1293.

    Google Scholar 

  182. Scott, I. M., B. A. McGaw, R. Horgan and P. E. Williams. Biochemical studies on cytokinins in Vinca rosea crown gall tissue. Plant Growth Subst Proc Int Conf 11th 1982; 1982: 165–174.

    Google Scholar 

  183. Atta-Ur-Rahman, I. Ali and M. Bashir. Isolation and structural studies on the alkaloids in flowers of Catharanthus roseus. J Nat Prod 1984; 47(3): 554–555.

    Article  PubMed  CAS  Google Scholar 

  184. Rahman, A-U and S. Malik. Isolation of isovallesiachotamine from legumes of Rhazya stricta. J Nat Prod 1984; 47(2): 388–389.

    Article  Google Scholar 

  185. Arnold, H. J. and M. Gulumian. Pharmacopoeia of traditional medicine in Venda. J Ethnopharmacol 1984; 12(1): 35–74.

    Article  PubMed  CAS  Google Scholar 

  186. Kohl, W., B. Witte, W. S. Sheldrick and G. Hofle. Indole alkaloids from Catharanthus roseus tissue cultures. IV. 16r-19,20-e-isositsirikin,16e-19,20-z- isositsirikin and 21-hydroxycyclolochnerin. Planta Med 1984; 1984(3): 242–244.

    Article  Google Scholar 

  187. De Bruyn, A., L. De Taeye, R. Simonds, M. Verzele and C. De Pauw. Alkaloids from Catharanthus roseus. Isolation and identification of 17 dessacetoxyvinblastine and 17-desacetoxyleurosine. Bull Soc Chim Belg 1982; 91(1) 75–85.

    Article  Google Scholar 

  188. Atta-Ur-Rahman, J. Fatima and K. Albert. Isolation and structure of rosicine from Catharanthus roseus. Tetrahedron Lett 1984; 25(52): 6051–6054.

    Article  CAS  Google Scholar 

  189. El-Sayed, A., G. A. Handy and G. A. Cordell. Catharanthus alkaloids. XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-n’(b)oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus. J Nat Prod 1983; 46(4): 517–527.

    Article  PubMed  CAS  Google Scholar 

  190. Tanaka, M., H. Shibata, K. Sato, S. Tanada and T. Uchida. Biosynthesis of extensin in suspension-cultured cells of Vinca rosea. Plant Tissue Cult Proc Int Congr Plant Tissue Cell Cult 5th 1982; 1982: 39–40.

    Google Scholar 

  191. De Taeye, L., A. De Bruyn, C. De Pauw and M. Verzele. Alkaloids of Vinca rosea: Isolation and identification of coronaridine. Bull Soc Chim Belg 1981; 90(1): 83–87.

    Article  Google Scholar 

  192. Barde, A. K. and S. M. Singh. Activity of plant extracts against Scytalidium anamorph of Hendersonula toruloidea causing skin and nail diseases in man. Indian Drugs 1983; 20(9): 362–364.

    Google Scholar 

  193. Petiard, V. Antimitotic activities of Catharanthus roseus tissue cultures. J Med 1981; 447–469.

    Google Scholar 

  194. Thompson, W. A. R. Herbs that heal. J Roy Coll Gen Pract 1976; 26: 365–370.

    CAS  Google Scholar 

  195. Kalyanasundaram, M. and P. K. Das. Larvicidal and synergistic activity of plant extracts for mosquito control. Indian J Med Res 1985; 82(1): 19–23.

    PubMed  CAS  Google Scholar 

  196. Chen, T. H. H., K. K. Kartha, N. L. Leung, W. G. W. Kurz, K. B. Chatson and F. Constabel. Cryopreservation of alkaloid-producing cell cultures of periwinkle (Catharanthus roseus). Plant Physiol 1985; 75: 726–731.

    Article  Google Scholar 

  197. Rojas, M. C. N. and M. C. A. Cuellar. Comparative microbiological studies of the alkaloids of Catharanthus roseus and other related compounds. Rev Cubana Farm 1981; 15(2): 131–138.

    Google Scholar 

  198. Chakraborty, T. and G. Poddar. Herbal drugs in diabetes — Part 1: Hypoglycaemic activity of indigenous plants in streptozotocin (STZ) induced diabetic rats. J Inst Chem (India) 1984; 56(1): 20–22.

    Google Scholar 

  199. Yang, L. L., K. Y. Yen, Y. Kiso and H. Kikino. Antihepatotoxic actions of Formosan plant drugs. J Ethnopharmacol 1987; 19(1): 103–110.

    Article  PubMed  CAS  Google Scholar 

  200. Ramirez, V. R., L. J. Mostacero, A. E. Garcia, C. F. Mejia, P. F. Pelaez, C. D. Medina and C. H. Miranda. Vegetales empleados en medicina tradicional Norperuana. Banco Agrario Del Peru & NACL Univ Trujillo, Trujillo, Peru, June 1988; 54pp.

    Google Scholar 

  201. Balsevich, J., L. R. Hogge, A. J. Berry, D. E. Games and I. C. Mylchreest. Analysis of indole alkaloids from leaves of Catharanthus roseus by means of supercritical fluid chromatography/ mass spectrometry. J Nat Prod 1988; 51(6): 1173–1177.

    Article  CAS  Google Scholar 

  202. Murugavel, T., A. Ruknudin, S. Thangavelu and M. A. Akbarsha. Antifertility effect of Vinca rosea (Linn.) leaf extract on male albino mice-A sperm parametric study. Curr Sci 1989; 58(19): 1102–1103.

    Google Scholar 

  203. Auriola, S., T. Naaranlahti and S. P. Lapinjoki. Determination of Catharanthus roseus alkaloids by high-performance liquid chromatography isotope dilution thermospray-mass spectrometry. J Chromatogr 1991; 554(1/2): 227–231.

    CAS  Google Scholar 

  204. Radvany, L. G. and F. Di Cosmo. Purification and characterization of calmodulin from cultured cells of Catharanthus roseus. Phytochem Anal 1991; 2(6): 241–252.

    Article  Google Scholar 

  205. Murugavel, T. and M. A. Akbarsha. Anti-spermatogenic effect of Vinca rosea Linn. Indian J Exp Biol 1991; 29(9): 810–812.

    PubMed  CAS  Google Scholar 

  206. Chattopadhyay, R. R., S. K. Sankar, S. Ganguly, B. N. Banerjee and T. K. Basu. Hypoglycemic and antihyper- glycemic effect of leaves of Vinca rosea Linn. Indian J Physiol Pharmacol 1991: 35(3): 145–151.

    PubMed  CAS  Google Scholar 

  207. Chopra, R. N., R. L. Badhwar and S. Ghosh. Poisonous Plants of India. Manager of Publications, Government of India Press, Calcutta. Volume 1, 1949.

    Google Scholar 

  208. Chang, S. Y., D. Y. Mao and P. Hsu. The antitumor action and toxicity of the alkaloidal fraction AC-875 from Vinca roseus. Yao Hsueh Hsueh Pao 1965; 12: 772–777.

    PubMed  CAS  Google Scholar 

  209. Svoboda, G. H., A. J. Barnes Jr. and R. J. Armstrong. Leurosidine and leurocristine and their production. PatentUS-3,205,220 1965.

    Google Scholar 

  210. Furuya, A., M. Ukita, Y. Kotani, M. Misawa and H. Tanaka. RNA hydrolysis to 5’ -ribonucleotides by phosphodiesterase from plant callus. Patent-Japan Kokai-73 33,903 1973.

    Google Scholar 

  211. Moza, B. K. and J. Trojanek. On alkaloids. VII. New alkaloids from Catharanthus roseus. Collect Czech Chem Commun 1963; 28: 1419.

    CAS  Google Scholar 

  212. Pillay, P. P. and T. N. Santha Kumari. The occurrence of alstonine in Lochnera rosea J Sci Ind Res-B 1961; 20: 458.

    Google Scholar 

  213. Shimuzu, M. and F. Uchimaru. The isolation of alkaloids from Vinca (Lochnera) rosea. Chem Pharm Bull 1959; 7: 713.

    Article  Google Scholar 

  214. Shimuzu, M. and F. Uchimaru. Isolation of alkaloids from Vinca (Lochnera) rosea. Chem Pharm Bull 1958; 6: 324.

    Article  Google Scholar 

  215. Hodge, W. H. and D. Taylor. The ethnobotany of the island Caribes of Dominica. WEBBIA 1956; 12: 513–644.

    Google Scholar 

  216. Prakash, A. O. and R. Mathur. Screening of Indian plants for antifertility activity. Indian J Exp Biol 1976; 14: 623–626.

    PubMed  CAS  Google Scholar 

  217. Ukita, M., A. Furuya, H. Tanaka and M. Misawa. 5’Phosphodiesterase formation by cultured plant cells. Agr Biol Chem 1973; 37: 2849–2854.

    Article  CAS  Google Scholar 

  218. Mueller-Oerlinghausen, B., W. Ngamwathana and P. Kanchanapee. Investigation into Thai medicinal plants said to cure diabetes. J Med Assoc Thailand 1971; 54: 105–111.

    CAS  Google Scholar 

  219. Svoboda, G. A. The alkaloids of Catharanthus roseus G. Donn (Vinca rosea L.). Current Topics in Plant Science. J. E. Gunckel (Ed.), Academic Press, New York 1969; 303–335.

    Google Scholar 

  220. Smith, S. L., W. E. Jones, D. E. Dorman, E. E. Logsdon and G. H. Svoboda. Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don). XXXIII. Isolation and characterization of new dimeric alkaloids. (Abstract). Lloydia 1974; 37(4): 645D.

    Google Scholar 

  221. Tabgkongchitr, U. Extraction of organic compounds from leaves of Vinca rosea Linn. Thesis-MS-Chulalongkorn Univ 1973; 1973: 42pp.

    Google Scholar 

  222. Bhandari, P. R. and B. Mukerji. Lochnera rosea Linn Reichb. Gauhati Ayurvedic Coll Mag 1959; 8: 1–4.

    Google Scholar 

  223. Heal, R. E., E. F. Rogers, R. T. Wallace and O. Starnes. A survey of plants for insecticidal activity. Lloydia 1950; 13: 89–162.

    Google Scholar 

  224. Attia, M. S., S. Ahmad, S. A. H. Zaidi and Z. Ahmed. Studies on the bacteriostatic properties of wild medicinal plants of Karachi (Pakistan) Region 1. Pak J Sci Ind Res 1972; 15: 199–207.

    Google Scholar 

  225. Kubas, J. Investigations on known or potential antitumoral plants by means of microbiological tests. Part III. Biological activity of some cultivated plant species in Neurospora crassa test. Acta Biol Cracov Ser Bot 1972; 15: 87–100.

    Google Scholar 

  226. Sottomayor, M., M. Lopez Serrano, F. DiCosmo and A. RosBarcelo. Purification and characterization of alpha3, 4′-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don. FERBS lett 1998; 428(3): 299–303.

    Article  CAS  Google Scholar 

  227. Schulte, A. E., R. van der Heijden and R. Verporte. Purification and characterization of mevalonate kinase from suspension-cultured cells of Catharantus roseus (L.) G. Don. Arch Biochem Biophys 2000; 378(2): 287–98.

    Article  PubMed  CAS  Google Scholar 

  228. Pina-Chable, M. L. and S. M. Sotomayor. Phospholipase C activity from Catharanthus roseus transformed roots: aluminum effect. Prostaglandins 2001; 65(1): 45–56.

    Article  PubMed  CAS  Google Scholar 

  229. Singh, S. N., P. Vats, S. Suri, R. Shyam, M. M. Kumria, S. Ranganathan and K. Sridharan. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities on streptozotocin induced diabetic rats. J Ethnopharmacol 2001; 76(3): 269–277.

    Article  PubMed  CAS  Google Scholar 

  230. Hague, N., S. A. Chowdhury, M. T. Nutan, G. M. Rahaman, K. M. Rahaman and M. A. Rashid. Evaluation of antitumor activity of some medicinal plants of Bangladesh by potato disk bioassay. Fitoterapia 2000; 71(5): 547–552.

    Article  Google Scholar 

  231. Spitsberg, V. L. and C. J. Coscia. Quinone reductases of higher plants. Eur J Biochem 1982; 127(1): 67–70.

    Article  PubMed  CAS  Google Scholar 

  232. Mukhopadhyay, S., A. El-Sayed, G. A. Handy and G. A. Cordell. Catharanthus alkaloids XXXVII. 16-Epi-Z-isositsirikine, a monomeric indole alkaloid with antineoplastic activity from Catharanthus roseus and Rhazya stricta. J Nat Prod 1983; 46(3): 409–413.

    Article  PubMed  CAS  Google Scholar 

  233. Mathur, R. and S. Chaudan. Antifertility efficacy of Catharanthus roseus Linn: a biochemical and histological study. Acta Eur Fertil 1985; 16(3): 203–205.

    PubMed  CAS  Google Scholar 

  234. Sedakova, L. A., I. K. Bukharova, I. D. Treshchalin and A. B. Syrkin. Antitumor and toxic effects of amotin. Eksp Onkol 1987; 9(5): 76–77.

    PubMed  CAS  Google Scholar 

  235. Song, K. M., S. W. Park, W. H. Hong, H. Lee, S. S. Kwak and J. R. Liu. Isolation of vindoline from Catharanthus roseus by supercritical fluid extraction. Biotechnol Prog 1992; 8(6): 583–586.

    Article  PubMed  CAS  Google Scholar 

  236. Hotze, M., G. Schroder and J. Schroder. Cinnamate 4-hydroxylase from Catharanthus roseus, and a strategy for the functional expression of plant cytochrome P450 proteins as translational fusions with P450 reductase in Escherichia col. FEBS Lett 1995; 374(3): 345–350.

    Article  PubMed  CAS  Google Scholar 

  237. Limam, F., K. Chahed, N. Ouelhazi, R. Ghrir and L. Ouelhazi. Phytohormone regulation of isoperoxidases in Catharanthus roseus suspension cultures. Phytochemistry 1998; 49(5): 1219–1225.

    Article  PubMed  CAS  Google Scholar 

  238. Chattopadhyay, R. R. A comparative evaluation of some blood sugar lowering agents of plant origin. J Ethnopharmacol 1999; 67(3): 367–372.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ross, I.A. (2003). Catharanthus roseus. In: Medicinal Plants of the World. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-365-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-365-1_8

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-469-2

  • Online ISBN: 978-1-59259-365-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics