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Electrical and Structural Remodeling of the Ventricular Myocardium in Disease

  • Chapter
Book cover Cardiac Repolarization

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Abnormalities of ventricular repolarization are a reoccurring feature of structural heart disease and likely contributors to the increased incidence of sudden death in patients with cardiac hypertrophy and heart failure (HF). Several clinical observations support this contention. Over two million Americans suffer from heart failure and more than 200,000 die annually. The incidence is estimated to be 400,000 per year with a prevalence of over 4.5 million, numbers that will increase with the aging of the US population (1). The majority of patients with heart failure have coronary artery disease as the cause of heart failure or concomitant with myocardial failure. Despite remarkable improvements in medical therapy the prognosis of patients with myocardial failure remains poor with over 15% of patients dying within one year of initial diagnosis and up to an 80% six-year mortality (2). Of the deaths in patients with heart failure, 50% are sudden and unexpected.

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Authors
  1. Antonis A. Armoundas PhD
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  2. Gordon F. Tomaselli MD
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Editor information

Editors and Affiliations

  1. eResearch Technology Inc., Bridgewater, NJ, USA

    Ihor Gussak MD, PhD

  2. Masonic Medical Research Laboratory, Utica, NY, USA

    Charles Antzelevitch PhD

  3. Mayo Clinic, Rochester, MN, USA

    Stephen C. Hammill MD  & Win-Kuang Shen MD  & 

  4. St. Louis University Health Sciences Center, St. Louis, MO, USA

    Preben Bjerregaard MD, DMSc

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© 2003 Springer Science+Business Media New York

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Armoundas, A.A., Tomaselli, G.F. (2003). Electrical and Structural Remodeling of the Ventricular Myocardium in Disease. In: Gussak, I., Antzelevitch, C., Hammill, S.C., Shen, WK., Bjerregaard, P. (eds) Cardiac Repolarization. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-362-0_7

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  • DOI: https://doi.org/10.1007/978-1-59259-362-0_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-336-7

  • Online ISBN: 978-1-59259-362-0

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