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Cardiac Repolarization pp 63–89Cite as

Electrophysiology and Pharmacology of Ventricular Repolarization

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Repolarization of the ventricular action potential is responsible for the inscription of the T wave and definition of the QT interval in the electrocardiogram (ECG). Repolarization forces play a determining role in the normal function of the myocardium and when defective are often responsible for the development of life-threatening arrhythmias. Thus, our understanding of the electrocardiographic representation of the electrical activity of the heart and appreciation of the mechanisms of arrhythmogenesis requires a fundamental knowledge of the mechanisms of repolarization and the degree to which they differ among the various cell types present within the ventricle of the heart.

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Authors
  1. Charles Antzelevitch PhD
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  2. Andrew C. Zygmunt PhD
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  3. Robert Dumaine PhD
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Editors and Affiliations

  1. eResearch Technology Inc., Bridgewater, NJ, USA

    Ihor Gussak MD, PhD

  2. Masonic Medical Research Laboratory, Utica, NY, USA

    Charles Antzelevitch PhD

  3. Mayo Clinic, Rochester, MN, USA

    Stephen C. Hammill MD  & Win-Kuang Shen MD  & 

  4. St. Louis University Health Sciences Center, St. Louis, MO, USA

    Preben Bjerregaard MD, DMSc

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Antzelevitch, C., Zygmunt, A.C., Dumaine, R. (2003). Electrophysiology and Pharmacology of Ventricular Repolarization. In: Gussak, I., Antzelevitch, C., Hammill, S.C., Shen, WK., Bjerregaard, P. (eds) Cardiac Repolarization. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-362-0_4

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