Skip to main content
SpringerLink
Log in

Established Therapies for Advanced Heart Failure

  • Chapter
Book cover Heart Failure

Part of the book series: Contemporary Cardiology ((CONCARD))

  • 157 Accesses

Abstract

Heart failure is a chronic, progressive disease. Despite advances in the management of heart failure over the past 30 years, many patients will progress to an advanced stage of the disease that negatively impacts their quality of life and ultimately leads to death. As our success in managing acute coronary syndromes and sudden cardiac death has improved, more patients are surviving to end-stage heart failure. Understanding the etiology of the progression and eliminating other causes of dyspnea or edema is the first step in the management of this challenging population. For younger patients without serious comorbidities, cardiac transplantation is an alternative that may extend the quantity and improve the quality of life. For those who are not transplant candidates, there are limited options, and often the focus becomes one of maintaining function and controlling symptoms, occasionally at the expense of mortality. In truly refractory heart failure, hospice care may be appropriate in order to maintain comfort and dignity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hunt HA, Baker DW, Chin MH, et al. ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the International Society for Heart and Lung Transplantation; Endorsed by the Heart Failure Society of America. Circulation 2001;104:2996–3007.

    Article  PubMed  CAS  Google Scholar 

  2. Mock MB, Ringqvist I, Fisher LD, et al. Survival of medically treated patients in the coronary artery surgery study (CASS) registry. Circulation 1982;66:562–568.

    Article  PubMed  CAS  Google Scholar 

  3. Morrison LK, Harrison A, Kirishraswamy P, Kazanegra R, Clapton P, Maisel A. Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J Am Coll Cardiol 2002;39:202–209.

    Article  PubMed  CAS  Google Scholar 

  4. Cabanes L, Richard-Thiriez B, Fulla Y, et al. Brain natriuretic peptide blood levels in the differential diagnosis of dyspnea. Chest 2001;120:2047–2050.

    Article  PubMed  CAS  Google Scholar 

  5. Nohria A, Lewis E, Stevenson LW. Medical management of advanced heart failure. JAMA 2002;287:628–640.

    Article  PubMed  Google Scholar 

  6. Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 1995;333:1190–1195.

    Article  PubMed  CAS  Google Scholar 

  7. Hawthorne MH, Hixon ME. Functional status, mood disturbance and quality of life in patients with heart failure. Prog Cardiovasc Nursing 1994;9:22–32.

    CAS  Google Scholar 

  8. Vaccarino V, Kasl VA, Abramson J, Krumholz HM. Depressive symptoms and risk of functional decline and death in patients with heart failure. J Am Coll Cardiol 2001;38:199–205.

    Article  PubMed  CAS  Google Scholar 

  9. MacMahon KM, Lip GY. Psychological factors in heart failure: a review of the literature. Arch Intern Med 2002;162:509–516.

    Article  PubMed  Google Scholar 

  10. Carney RM, Freedland KE, Eisen SA, Rich MW, Jaffe AS. Major depression and medication adherence in elderly patients with coronary artery disease. Health Psychol 1995;14:88–90.

    Article  PubMed  Google Scholar 

  11. Mudaliar S, Henry RR. New oral therapies for type 2 diabetes mellitus: the glitazones or insulin sensitizers. Ann Rev Med 2001;52:239–257.

    Article  PubMed  CAS  Google Scholar 

  12. Schoonjans K, Auwerx J. Thiazolidinediones: an update. Lancet 2000;355:1008–1010.

    Article  PubMed  CAS  Google Scholar 

  13. Page J, Henry D. Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underrecognized public health problem. Arch Intern Med 2000;160:777–784.

    Article  PubMed  CAS  Google Scholar 

  14. Dzau VJ, Packer M, Lilly IS, Swartz SL, Hollenberg NK, Williams GH et al. Prostaglandins in severe congestive heart failure. Relation to activation of the renin-angiotensin system and hyponatremia. N Engl J Med 1984;310:347–352.

    Article  PubMed  CAS  Google Scholar 

  15. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987;316:1429–435.

    Article  Google Scholar 

  16. Packer M, Coats, AJ, Fowler MB, et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001;344:1651–1658.

    Article  PubMed  CAS  Google Scholar 

  17. Badgett RG, Lucey CR, Mulrow CD. Can the clinical examination diagnose leftsided heart failure in adults? JAMA 1997;277:1712–1719.

    Article  PubMed  CAS  Google Scholar 

  18. Stevenson LW, Tillisch JH, Hamilton M, et al. Importance of hemodynamic response to therapy in predicting survival with ejection fraction less than or equal to 20% secondary to ischemic or nonischemic dilated cardiomyopathy. Am J Cardiol 1990; 66:1348–1354.

    Article  PubMed  CAS  Google Scholar 

  19. McAlister FA, Lawson FM, Teo KK, Armstrong PW. A systematic review of randomized trials of disease management programs in heart failure. Am J Med 2001;110:378–84.

    Article  PubMed  CAS  Google Scholar 

  20. Rich MW. Heart failure disease management programs: efficacy and limitations. Am J Med 2001;110:410–412.

    Article  PubMed  CAS  Google Scholar 

  21. Hosenpud JD, Bennett LE, Keck BM, Boucek MM, Novick RJ. The Registry of the International Society for Heart and Lung Transplantation: eighteenth Official Report-2001. J Heart Lung Transplant 2001;20:805–815.

    Article  PubMed  CAS  Google Scholar 

  22. Mudge GH, Goldstein S, Addonizio LJ, et al. 24th Bethesda conference: Cardiac transplantation. Task Force 3: recipient guidelines/prioritization. J Am Coll Cardiol 1993;22:21–31.

    Article  PubMed  CAS  Google Scholar 

  23. Dec GW, Semigran MJ, Vlahakes GJ. Cardiac transplantation: current indications and limitations. Transplant Proc 1991;23:2095–2106.

    PubMed  CAS  Google Scholar 

  24. Miniati DN, Robbins RC. HEART TRANSPLANTATION: a thirty-year perspective. Annu Rev Med 2002;53:189–205.

    Article  PubMed  CAS  Google Scholar 

  25. Stevenson WG, Stevenson LW, Middlekauff HR, et al. Improving survival for patients with advanced heart failure: a study of 737 consecutive patients. J Am Coll Cardiol 1995;26:1417–1423.

    Article  PubMed  CAS  Google Scholar 

  26. Stevenson LW. Selection and management of candidates for heart transplantation. Curr Opin Cardiol 1996;11:166–173.

    Article  PubMed  CAS  Google Scholar 

  27. Mancini DM, Eisen H, Kussmaul W, Mull R, Edmunds LH Jr., Wilson JR. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 1991;83:778–786.

    Article  PubMed  CAS  Google Scholar 

  28. Felker GM, O’Connor CM. Inotropic therapy for heart failure: an evidence-based approach. Am Heart J 2001;142:393–401.

    Article  PubMed  CAS  Google Scholar 

  29. Morrone TM, Buck LA, Catanese KA, et al. Early progressive mobilization of patients with left ventricular assist devices is safe and optimizes recovery before heart transplantation. J Heart Lung Transplant 1996;15:423–429.

    PubMed  CAS  Google Scholar 

  30. Kobashigawa JA. Advances in immunosuppression for heart transplantation. Adv Cardiac Surg 1998;10:155–174.

    CAS  Google Scholar 

  31. Rose EA, Gelijns AC, Moskowritz AJ, et al. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 2001;345:1435–1443.

    Article  PubMed  CAS  Google Scholar 

  32. Krumholz HM, Phillips RS, Hamel MB, et al. Resuscitation preferences among patients with severe congestive heart failure: results from the SUPPORT project. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Circulation 1998;98:648–6655.

    Article  PubMed  CAS  Google Scholar 

  33. Ewey GA. Inotropic infusions for chronic congestive heart failure: medical miracles or misguided medicinals? J Am Coll Cardiol 1999;33:572–575.

    Article  Google Scholar 

  34. Hatzizacharias A, Makris T, Krespi P, et al. Intermittent milrinone effect on longterm hemodynamic profile in patients with severe congestive heart failure. Am Heart J 1999;138:241–246.

    Article  PubMed  CAS  Google Scholar 

  35. Nieminen MS, Akkila J, Hasenfuss, G, et al. Hemodynamic and neurohumoral effects of continuous infusion of levosimendan in patients with congestive heart failure. J Am Coll Cardiol 2000;36:1903–1912.

    Article  PubMed  CAS  Google Scholar 

  36. O’Connor C, Gattis W, Uretsky B, et al. Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST). Am Heart J 1999;138:78–86.

    Article  PubMed  Google Scholar 

  37. Mehra MR, Uber PA. The dilemma of late-stage heart failure. Rationale for chronic parenteral inotropic support. Cardiol Clin 2001;19:627–636.

    Article  PubMed  CAS  Google Scholar 

  38. Stevenson WG, Stevenson LW. Prevention of sudden death in heart failure. J Cardiovasc Electrophysiol 2001;12:112–114.

    Article  PubMed  CAS  Google Scholar 

  39. Albert NM, Davis M, Young J. Improving the care of patients dying of heart failure. Cleveland Clin J Med 2002;69:321–328.

    Article  Google Scholar 

Download references

Authors
  1. Lee R. Goldberg MD, MPH, FACC
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Heart Failure/Transplant Program, University of Pennsylvania Health System, Philadelphia, PA, USA

    Mariell L. Jessup MD, FACC, FAHA

  2. University of Pennsylvania Health System, Philadelphia, PA, USA

    Evan Loh MD, FACC, FAHA

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Humana Press Inc., Totowa, NJ

About this chapter

Cite this chapter

Goldberg, L.R. (2003). Established Therapies for Advanced Heart Failure. In: Jessup, M.L., Loh, E. (eds) Heart Failure. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-347-7_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-347-7_19

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9759-5

  • Online ISBN: 978-1-59259-347-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation