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Molecular Biology of Drug Addiction pp 79–106Cite as

Recent Advances in the Molecular Mechanisms of Psychostimulant Abuse Using Knockout Mice

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Abstract

In the last years, generalization of homologous recombination approaches in the mouse has been extremely fruitful for our general understanding of the molecular mechanisms underlying the acute and chronic effects of psychostimulant drugs. Indeed, this technique based on genetic manipulations provides advantages that surpass inconveniences from pharmacological tools and offer unexpected insights into the field of action of psychostimulant drugs. For example, the extremely sharp precision of gene invalidation surpasses the specificity of drugs that can be available for in vivo experiments, and this is especially important in the study of psychostimulants given that these drugs are not specific within the family of their target proteins. Also, even though the technique may be hampered by genetic heterogeneity and developmental adaptations bias, the life-long consequences of the gene deletion together with the possibility of a reliable reproducibility in animal groups present a strong and exciting basis of investigation.

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Authors
  1. Cécile Spielewoy
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  2. Bruno Giros
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Editors and Affiliations

  1. Laboratory of Neuropharmacology Health and Life Sciences School, Universitat Pompeu Fabra, Barcelona, Spain

    Rafael Maldonado

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Spielewoy, C., Giros, B. (2003). Recent Advances in the Molecular Mechanisms of Psychostimulant Abuse Using Knockout Mice. In: Maldonado, R. (eds) Molecular Biology of Drug Addiction. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-343-9_6

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  • DOI: https://doi.org/10.1007/978-1-59259-343-9_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-330-5

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