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Different Intracellular Signaling Systems Involved in Opioid Tolerance/Dependence

  • Chapter
Molecular Biology of Drug Addiction

Abstract

Although opioids are highly effective for the treatment of pain, they are also known to be intensively addictive. After chronic opioid intake, the drug becomes less effective, so that higher doses are needed to produce the same effect as before —a phenomenon that is called tolerance. At the same time, a situation develops in which the interruption of taking the drugs results in withdrawal sickness, unmasking a state called dependence (1). Both tolerance and dependence result from biochemical changes in the brain.

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Authors
  1. Thomas Koch
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  2. Stefan Schulz
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  3. Volker Höllt
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Editors and Affiliations

  1. Laboratory of Neuropharmacology Health and Life Sciences School, Universitat Pompeu Fabra, Barcelona, Spain

    Rafael Maldonado

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Koch, T., Schulz, S., Höllt, V. (2003). Different Intracellular Signaling Systems Involved in Opioid Tolerance/Dependence. In: Maldonado, R. (eds) Molecular Biology of Drug Addiction. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-343-9_4

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  • DOI: https://doi.org/10.1007/978-1-59259-343-9_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-330-5

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