Abstract
Advances in modalities of treatment and improvements in long-term survival in children with brain tumors have resulted in a need to evaluate the late effects of cancer therapy on endocrine function in children. Long-term impairment of growth and sexual development are well-known complications of brain tumors and their treatments, although multiple endocrine systems may be altered following surgery, radiotherapy, and chemotherapy. In addition, co-morbidities of cancer therapy, such as nutritional deficiencies, psychosocial dysfunction, and the disease process itself, may amplify the deleterious effects of cancer treatment on the endocrine system. The aims of this review are to summarize the effects of brain tumors and their treatments on the endocrine system and to outline the management of endocrinopathies in survivors of childhood brain tumors.
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Weinzimer, S.A., Moshang, T. (2003). Management of Endocrine Dysfunction Following Brain Tumor Treatment. In: Radovick, S., MacGillivray, M.H. (eds) Pediatric Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-336-1_10
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