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Cytokines in Allogeneic Stem Cell Mobilization

  • Chapter
Allogeneic Stem Cell Transplantation

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Since the mid-1990s when the first trials of cytokine-mobilized allogeneic peripheral blood stem cell (allo-PBSC) transplants appeared in the literature, there has been a steady increase in the use of allo-PBSC in lieu of bone marrow as a source of stem cells. For normal donors, the collection of PBSC by apheresis techniques is a feasible alternative to undergoing marrow harvest with anesthesia and avoids the potential morbidity associated with marrow collection. This trend has further accelerated with the publication of a randomized trial suggesting a superior survival for patients where peripheral blood was used as a source of stem cells over the use of bone marrow (1).

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Authors
  1. Ravi Vij MD
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  2. Randy Brown MD
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  3. John F. DiPersio MD,PhD
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Editor information

Editors and Affiliations

  1. Allogeneic Transplant Program, Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA

    Mary J. Laughlin MD

  2. Blood and Marrow Transplant Program, Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA

    Hillard M. Lazarus MD

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© 2003 Springer Science+Business Media New York

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Vij, R., Brown, R., DiPersio, J.F. (2003). Cytokines in Allogeneic Stem Cell Mobilization. In: Laughlin, M.J., Lazarus, H.M. (eds) Allogeneic Stem Cell Transplantation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-333-0_12

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  • DOI: https://doi.org/10.1007/978-1-59259-333-0_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4481-1

  • Online ISBN: 978-1-59259-333-0

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