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Umbilical Cord Blood Transplantation

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Book cover Allogeneic Stem Cell Transplantation

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Transplantation of allogeneic hematopoietic stem cells (HSC) derived either from sibling or unrelated donor bone marrow (BM) or mobilized peripheral blood (PB) have been successfully utilized in the treatment of high risk or recurrent hematological malignancies, BM failure syndromes, hemoglobinopathies, selected hereditary immunodeficiency states, and inborn errrors of metabolism (1). However, a number of limitations exist that impede the successful use of such HSC transplant therapy. The first of these is the unavailability of suitable donors. With current trends in family size in the U.S. fewer than 35% of patients will have an human leukocyte antigen (HLA)-matched sibling (2). While there are currently more than 5 million HLA-typed marrow donors registered in BM donor registries worldwide, substantial numbers of patients are still unable to find an available, suitably HLA-matched BM donor. For example, although an initial search may identify at least one potential HLA-matched donor for 85% of Caucasian patients, 40% of African-American or Asian-Pacific-Islanders will not have a matched donor (3–5). Further, because of the heterogeneity of HLA haplotypes seen in some racial groups, such as African-Americans, HLA-matched BM may be unavailable regardless of registry size (6). Also, the unrelated BM donor search process can be lengthy, taking 3.7 mo on average (5).

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Authors
  1. Juliet Barker MBBS (Hoes)
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  2. John E. Wagner MD
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Editor information

Editors and Affiliations

  1. Allogeneic Transplant Program, Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA

    Mary J. Laughlin MD

  2. Blood and Marrow Transplant Program, Ireland Cancer Center, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA

    Hillard M. Lazarus MD

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Barker, J., Wagner, J.E. (2003). Umbilical Cord Blood Transplantation. In: Laughlin, M.J., Lazarus, H.M. (eds) Allogeneic Stem Cell Transplantation. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-333-0_10

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  • DOI: https://doi.org/10.1007/978-1-59259-333-0_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4481-1

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