Abstract
Acute limb ischemia arises when a rapid or sudden decrease in limb perfusion threatens tissue viability. This form of critical limb ischemia may be the first manifestation of vascular disease in a previously asymptomatic patient or occur as an acute event causing symptomatic deterioration in a patient with antecedent intermittent claudication. Although the progression of peripheral arterial disease (PAD) from intermittent claudication (IC) to critical limb ischemia (CLI) may occur gradually, it may reflect the cumulative effect of multiple acute events that progressively increase the intensity of ischemia.
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Halperin, J.L. (2003). Acute Limb Ischemia. In: Coffman, J.D., Eberhardt, R.T. (eds) Peripheral Arterial Disease. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-331-6_7
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