Abstract
The traditional notion regarding cerebellar function has been that it is important for coordinating voluntary motor activity (1). Early studies of patients with degenerative cerebellar diseases or focal cerebellar injuries (2) described ataxia (wide-based lurching gait) and dysmetria (inaccuracy and wavering unsteadiness or dysrhythmia of directed extremity movements). These observations led to the conclusion that when cerebellum malfunctions, balance and coordination are impaired, tremor is evident, eye movements are disordered, speech is dysarthric, and handwriting is illegible. Theories of cerebellar function, experiments to test the role of the cerebellum in nervous system, and the interpretation of previously available cerebellar anatomy have been predicated on the hypothesis that cerebellum is a motor control device.
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References
Adams, R.D. and Victor M. (2000) Principles of Neurology, McGraw Hill, New York.
Holmes, G. (1917) The symptoms of acute cerebellar injuries due to gunshot wounds. Brain 40, 461–535.
Dow, R.S. and Moruzzi, G. (1958) The Physiology and Pathology of the Cerebellum, University of Minnesota Press, Minneapolis.
Dow, R.S. (1974) Some novel concepts of cerebellar physiology. Mt. Sinai. J. Med. 41,103–119.
Watson, P.J. (1978) Nonmotor functions of the cerebellum. Psychol. Bull. 85, 944–967.
Leiner, H.C., Leiner, A.L., and Dow, R.S. (1986) Does the cerebellum contribute to mental skills? Behay. Neurosci. 100, 443–454.
Schmahmann, J.D. (1991) An emerging concept: the cerebellar contribution to higher function. Arch. Neurol. 48, 1178–1187, and (1992) 49, 1230.
Schmahmann, J.D. (1997) Rediscovery of an early concept, in Int. Rev. Neurobiol., volume 41, The Cerebellum and Cognition (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 3–27.
Schmahmann, J.D. (Ed.) (1997) Int. Rev. Neurobiol., volume 41, The Cerebellum and Cognition, Academic Press, San Diego.
Schmahmann, J.D. (1998) Dysmetria of thought. Clinical consequences of cerebellar dysfunction on cognition and affect. Trends Cogn. Sci. 2, 362–370.
Schmahmann, J.D. (2000) The role of the cerebellum in affect and psychosis. J. Neurolinguistics 13, 189–214.
Schmahmann, J.D. (2001) The cerebrocerebellar system: anatomic substrates of the cerebellar contribution to cognition and emotion. Int. Rev. Psychiatry 13, 247–260.
Schmahmann, J.D. (2001) The cerebellar cognitive affective syndrome: clinical correlations of the dysmetria of thought hypothesis. Int. Rev. Psychiatry 13, 313–322.
Moruzzi, G. (1947) Sham rage and localized autonomic responses elicited by cerebellar stimulation in the acute thalamic cat. Proc. XVII Internat Congress Physiol Oxford, pp. 114–115.
Martner, J. (1975) Cerebellar influences on autonomic mechanisms. Acta Physiol. Scand. 425(Suppl.), 1–42.
Bard, P. (1928) A diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system. Am. J. Physiol. 84, 490–515.
Zanchetti, A. and Zoccolini, A. (1954) Autonomic hypothalamic outbursts elicited by cerebellar stimulation. J. Neurophysiol. 17, 475–483.
Reis, D.J., Doba, N., and Nathan, M.A. (1973) Predatory attack, grooming and consummatory behaviors evoked by electrical stimulation of cat cerebellar nuclei. Science 182, 845–847.
Snider, R.S. (1950) Recent contributions to the anatomy and physiology of the cerebellum. Arch. Neuro. Psychol. 64, 196–219.
Man, D. (1969) A theory of cerebellar cortex. J. Physiol. 202, 437–470.
Albus, J.S. (1971) A theory of cerebellar function. Math Biosc. 10, 25–61.
Thompson, R.F., Bao, S., Chen, L., et al. (1997) Associative learning, in The Cerebellum and Cognition (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 151–189.
Lalonde, R. (1997) Visuospatial abilities, in The Cerebellum and Cognition (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 191–216.
Petrosini, L., Molinari, M., and Dell’Anna, M.E. (1996) Cerebellar contribution to spatial event processing: Morris water maze and T-maze. Eur. J. Neurosci. 9, 1896–1996.
Voogd, J. and Glickstein, M. (1998) The anatomy of the cerebellum. Trends Neurosci. 21, 370–375.
Hawkes, R., Colonnier, M., and Leclerc, N. (1985) Monoclonal antibodies reveal sagittal banding in the rodent cerebellar cortex. Brain Res. 6, 359–365.
Haines, D.E. (1981) Zones in the cerebellar cortex. Their organization and potential relevance to cerebellar stimulation. J. Neurosurg. 55, 254–256.
Noda, H., Sugita, S., and Ikeda, Y. (1990) Afferent and efferent connections of the oculomotor region of the fastigial nucleus in the macaque monkey. J. Comp. Neurol. 302, 330–348.
Qvist, H. (1989) Demonstration of axonal branching of fibres from certain precerebellar nuclei to the cerebellar cortex and nuclei: a retrograde fluorescent double-labelling study in the cat. Exp. Brain Res. 75, 15–27.
Gonzalo-Ruiz, A. and Leichnetz, G.R. (1998) Connections of the caudal cerebellar interpositus complex in a new world monkey (Cebus apella). Brain Res. Bull. 25, 919–927.
Andrezik, J.A., Dormer, K.J., Foreman, R.D., and Person, R.J. (1984) Fastigial nucleus projections to the brain stem in beagles: pathways for autonomic regulation. Neuroscience 11, 497–507.
Miller, R.A. and Strominger, N.L. (1977) An experimental study of the efferent connections of the superior cerebellar peduncle in the rhesus monkey. Brain Res. 133, 237–250.
Person, R.J., Andrezik, J.A., Dormer, K.J., and Foreman, R.D. (1986) Fastigial nucleus projections in the midbrain and thalamus in dogs. Neuroscience 18, 105–120.
Aumann, T.D. and Home, M.K. (1996) Ramification and termination of single axons in the cerebellothalamic pathway of the rat. J. Comp. Neurol. 376, 420–430.
Snider, R.S. (1975) A cerebellar-ceruleus pathway. Brain Res. 88, 59–63.
Dempsey, C.W., Tootle, D.M., Fontana, C.J., Fitzjarrell, A.T., Garey, RE., and Heath R.G. (1983) Stimulation of the paleocerebellar cortex of the cat: increased rate of synthesis and release of catecholamines at limbic sites. Biol. Psychiat. 18, 127–132.
Marcinkiewicz, M., Morcos, R., and Chretien, M. (1989) CNS connections with the median raphe nucleus: retrograde tracing with WGA-apoHRP-gold complex in the rat. J. Comp. Neurol. 289, 11–35.
Moruzzi, G. (1940) Paleocerebellar inhibition of vasomotor and respiratory carotid sinus reflexes. J. Neurophysiol. 3, 20–32.
Paton, J.F. and Spyer, K.M. (1990) Brain stem regions mediating the cardiovascular responses elicited from the posterior cerebellar cortex in the rabbit. J. Physiol. (Lond.) 427, 533–552.
Reis, D.J. and Golanov, E.V. (1997) Autonomic and vasomotor regulation, in The Cerebellum and Cognition (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 121–149.
Xu, F. and Frazier, D.T. (1997) Involvement of the fastigial nuclei in vagally mediated respiratory responses. J. Appl. Physiol. 82, 1853–1861.
Coghill, R.C., Sang, C.N., Maisog, J.M., and Iadarola, M.J. (1999) Pain intensity processing within the human brain: a bilateral, distributed mechanism. J. Neurophvsiol. 82, 1934–1943.
Ploghaus, A., Tracey, I., Gati, J.S., et al. (1999) Dissociating pain from its anticipation in the human brain. Science 284, 1979–1981.
Parsons, L.M., Egan, G., Liotti, M., et al. (2001) Neuroimaging evidence implicating cerebellum in the experience of hypercapnia and hunger for air. Proc. Natl. Acad. Sci. USA 98, 2041–2046.
Tataranni, P.A., Gautier, J.F., Chen, K., et al. (1999) Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc. Natl. Acad. Sci. USA 96, 4569–4574.
Haines, D.E., Dietrichs, E., Mihailoff, G.A., and McDonald, E.F. (1997) The cerebellar-hypothalamic axis: basic circuits and clinical observations, in The Cerebellum and Cognition (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 83–107.
Whiteside, D.G. and Snider, R.S. (1953) Relation of cerebellum to upper brain stem. J. Neurophysiol. 16, 39
Heath, R.G. and Harper, J.W. (1974) Ascending projections of the cerebellar fastigial nucleus to the thippocampus amygdala and other temporal lobe sites: evoked potential and histological studies in monkeys and cats. Exp. Neurol. 45, 2682–2687.
Mutani, R. (1967) Cobalt experimental hippocampal epilepsy in the cat. Epilepsia 8, 22.3–240
Babb, T.L., Mitchell, A.G. Jr., and Crandall, P.H. (1974) Fastigiobulbar and dentatothalamic influences on hippocampal cobalt epilepsy in the cat. Electroencephalogr. Clin. Neurophysiol. 36, 141–154.
Heath, R.G., Dempsey, C.W., Fontana, C.J., and Myers, W.A. (1978) Cerebellar stimulation: effects on septal region, hippocampus, and amygdala of cats and rats. Biol. Psychiat. 13, 501–529.
Snider, R.S. and Maiti, A. (1976) Cerebellar contributions to the Papez circuit. J. Neurosci. Res. 2, 133–146.
Oades, R.D. and Halliday, G.M. (1987) Ventral tegmental (A10) system: neurobiology. 1. Anatomy ana connectivity. Brain Res. 434, 117–165.
Aas, J.-E. and Brodal, P. (1988) Demonstration of topographically organized projections from the hypothalamus to the pontine nuclei: an experimental study in the cat. J. Comp. Neurol. 268, 313–328.
Ebert, D. and Ebmeier, K.P. (1996) The role of the cingulate gyrus in depression: trom tunctional anatomy to neurochemistry. Biol. Psychiatry 39, 1044–1050.
Rauch, S.L., Jenike, M.A., Alpert, N.M., et al. (1994) Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch. Gen. Psychiatry 1, 62–70..
Vilensky, J.A. and Van Hoesen, G.W. (1981) Corticopontine projections from the cingulate cortex in the rhesus monkey. Brain Res. 205, 391–395.
Brodai, P., Bjaali, J.G., and Aas, J.E. (1991) Organization of cingulo-ponto-cerebellar connections in me cat. Anat. Embryol. (Berl.) 184, 245–254.
Schmahmann, J.D. (1996) From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing. Hum. Brain Mapping 4, 174–198.
Sunderland, S. (1940) The projection of the cerebral cortex on the pons and cerebellum in the macaque monkey. J. Anat. 74, 201–226.
Nyby, O. and Jansen, J. (1951) An experimental investigation of the corticopontine projection in macaca muiatta. Shifter utgitt av Det Norske Videnskaps-Akademi: Oslo; 1. Mat. Naturv. Klasse. 3, 1–47.
Brodal, P. (1978) The corticopontine projection in the rhesus monkey. Origin and principles of organization. Brain 101, 251–283.
Schmahmann, J.D. and Pandya, D.N. (1995) -Prefrontal cortex projections to the basilar pons: implications tor the cerebellar contribution to higher function. Neurosci. Lett. 199, 175–178.
Schmahmann, J.D. and Pandya, D.N. (1997) Anatomic organization of the basilar pontine projections trom pretrontal cortices in rhesus monkey. J. Neurosci. 17, 438–458.
Astruc, J. (1971) Corticofugal connections of area 8 (frontal eye field) in macaca mulatta. Brain Res. 33, 241–256.
Küinzle, H. and Akert K. (1977) Efferent connections of cortical area 8 (frontal eye lid) in Macaca tascicuiaris. A reinvestigation using the autoradiographic technique. J. Comp. Neurol. 173, 147–164.
Fuster, J.M. (1980) The Prefrontal Cortex: Anatomy, Physiology and Neuropsychology of the Frontal Lobe. Raven Press, New York.
Stanton, G.B., Goldberg, M.E., and Bruce, C.J. (1988) Frontal eye field efferents in the macaque monkey: 11. opography of terminal fields in midbrain and pons. J. Comp. Neurol. 271, 493–506.
Petrides, M. and Pandya, D.N. (1994) Comparative architectonic analysis of the human and the macaque frontal cortex, in Handbook of Neuropsychology, vol. 9 (Boller, F. and Grafman, J., eds.), Elsevier, New York, pp. 17–57.
Hyvarinen, J. (1982) Posterior parietal lobe of the primate brain. Physiol. Rev. 62, 1060–1129.
Schmahmann, J.D. and Pandya DN. (1989) Anatomical investigation of projections to the basis pontis from posterior parietal association cortices in rhesus monkey. J. Comp. Neurol. 289, 53–73.
Critchley, M. (1953) The Parietal Lobes. Hafner Press, New York.
Denny-Brown, D. and Chambers, R.A. (1958) The parietal lobe and behavior. Res. Publ. Assoc. Nerv. Ment Dis. 36, 35–117.
Glickstein, M., May, J.G., and Mercier, B.E. (1985) Corticopontine projection in the macaque: the distribution of labeled cortical cells after large injections of horseradish peroxidase in the pontine nuclei. J. Comp. Neurol. 235, 343–359.
May, J.G. and Andersen, R.A. (1986) Different patterns of corticopontine projections from separate cortical fields within the inferior parietal lobule and dorsal prelunate gyrus of the macaque. Exp. Brain Res. 63, 265–278.
Perrett, D.I., Mistlin, A.J., and Chitty, A.J. (1987) Visual neurons responsive to faces. Trends Neurosci. 10, 358–364.
Schmahmann, J.D. and Pandya, D.N. (1991) Projections to the basis pontis from the superior temporal sulcus and superior temporal region in the rhesus monkey. J. Comp. Neurol. 308, 224–248.
Ungerleider, L.G., Desimone, R., Galkin, T.W., and Mishkin, M. (1984) Subcortical projections of area MT in the macaque. J. Comp. Neurol. 223, 368–386.
Desimone, R. and Ungerleider, L.G. (1989) Neural mechanisms of visual processing in monkeys, in Handbook of Neurophysiology, vol. 2 (Boller, F. and Grafman, J., eds), Elsevier, Amsterdam, pp. 267–299.
Schmahmann, J.D. and Pandya, D.N. (1993) Prelunate, occipitotemporal, and parahippocampal projections to the basis pontis in rhesus monkey. J. Comp. Neurol. 337, 94–112.
Fries, W. (1990) Pontine projection from striate and prestriate visual cortex in the macaque monkey: an anterograde study. Vis. Neurosci. 4, 205–216.
Boussaoud, D., Desimone, R., and Ungerleider, L.G. (1991) Visual topography of area TEO in the macaque. J. Comp. Neurol. 306, 554–575.
Nadel, L. (1991) The hippocampus and space revisited. Hippocampus 1, 221–229.
Picard, N. and Strick, P.L. (1996) Motor areas of the medial wall: a review of their location and functional activation. Cereb. Cortex 6, 342–353.
Devinsky, O., Morrell, M.J., and Vogt, B.A. (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118, 279–306.
Paus, T. (2001) Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat. Rev. Neurosci. 2, 417–424.
Mesulam, M.-M. and Mufson, E.J. (1985) The insula of reil in man and monkey. Architectonics, connectivity, and function, in Cerebral Cortex, vol. 4 (Peters, A. and Jones E.G., eds.), Plenum Press. New York. no. 179–226.
Schmahmann, J.D. and Pandya, D.N. (1992) Fiber pathways to the pons from parasensory association cortices in Rhesus Monkey. J. Comp. Neurol. 326, 159–179.
Schmahmann, J.D. and Pandya, D.N. (1997) The cerebrocerebellar system, in The Cerebellum and Cognition (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 31–60.
Alexander, G.E., DeLong, M.R., and Strick, P.L. (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9, 357–381.
Kuypers, H.G.J.M. and Lawrence, D.G. (1967) Cortical projections to the red nucleus and the brainstem in the rhesus monkey. Brain Res. 4, 151–188.
Humphrey, D.R., Gold, R., and Reed, D.J. (1984) Sizes, laminar and topographic origins of cortical projections to the major divisions of the red nucleus in the monkey. J. Comp. Neurol. 225, 75–94.
Kennedy, P.R., Gibson, A.R., and Houk, J.C. (1986) Functional and anatomic differentiation between parvicellular and magnocellular regions of red nucleus in the monkey. Brain Res. 364, 124–136.
Saint-Cyr, J.A. and Courville, J. (1980) Projections from the motor cortex, midbrain, and vestibular nuclei to the inferior olive in the cat: anatomical and functional correlates, in The Inferior Olivary Nucleus: Anatomy and Physiology (Courville, J., DeMontigny, C., and Lamarre, Y., eds.), Raven Press, New York, pp. 97–124.
Shah, V.S., Schmahmann, J.D., Pandya, D.N., and Vaher, P.R. (1997)Associative projections to the zona incerta: possible anatomic substrates for extension of the Marr-Albus hypothesis to non-motor learning. Soc. Neurosci. Abstr. 23, 1829.
Allen, G.I., and Tsukahara, N. (1974) Cerebrocerebellar communication systems. Physiol. Rev. 54, 957–1008.
Stein, J.R. and Glickstein, M. (1992) Role of the cerebellum in visual guidance of movement. Physiol. Rev. 72, 967–1017.
Sasaki, K., Oka, H., Matsuda, Y., Shimono, T., and Mizuno, N. (1975) Electrophysiological studies of the projections from the parietal association area to the cerebellar cortex. Exp. Brain Res. 23, 91–102.
Brodal, P. (1979) The pontocerebellar projection in the rhesus monkey: an experimental study with retrograde axonal transport of horseradish peroxidase. Neuroscience 4, 193–208.
Strick, P.L. (1999) Symposium: basal ganglia, cerebellum and motor control. Soc. Neurosci. Abstr. 25, 528.
Jansen, J. and Brodai, A. (1940) Experimental studies on the intrinsic fibers of the cerebellum. II. The corticonuclear projection. J. Comp. Neurol. 73, 267–321.
Chambers, W.W. and Sprague, J.M. (1955) Functional localization in the cerebellum. I. Organization in longitudinal corticonuclear zones and their contribution to the control of posture, both extrapyramidal and pyramidal. J. Comp. Neurol. 103, 105–130.
Haines, D.E. (1989) HRP study of cerebellar corticonuclear-nucleocortical topography of the dorsal culminate lobule-lobule V-in a prosimian primate (Galago): with comments on nucleocortical cell types. J. Comp. Neurol. 282, 274–292.
Dow, R.S. (1942) The evolution and anatomy of the cerebellum. Biol. Rev. 17, 179–220.
Brodal, A. (1981) Neurological Anatomy in Relation to Clinical Medicine, Oxford University Press, New York.
Olszewski, J. (1952) The Thalamus of the Macaca Mulatta, S. Karger. Basel.
Strick, P.L. (1976) Anatomical analysis of ventrolateral thalamic input to primate motor cortex. J. Neurophysiol. 39, 1020–1031.
Batton, R.R. III, Jayaraman, A., Ruggiero, D., and Carpenter, M.B. (1977) Fastigial efferent projections in the monkey: an autoradiographic study. J. Comp. Neurol. 174, 281–306.
Thach, W.T. and Jones, E.G. (1979) The cerebellar dentatothalamic connection: terminal field, lamellae, rods and somatotopy. Brain Res. 169, 168–172.
Stanton, G.B. (1980) Topographical organization of ascending cerebellar projections from the dentate and interposed nuclei in Macaca mulatta: an anterograde degeneration study. J. Comp. Neurol. 190, 699–731.
Kalil, K. (1981) Projections of the cerebellar and dorsal column nuclei upon the thalamus of the rhesus monkey. J. Comp. Neurol. 195, 25–50.
Wiesendanger, R. and Wiesendanger, M. (1985) The thalamic connections with medial area 6 (supplementary motor cortex) in the monkey (Macaca fascicularis). Exp. Brain Res. 59, 91–104.
Ilinsky, I.A. and Kultas-Ilinsky, K. (1987) Sagittal cytoarchitectonic maps of Macaca mulatta. J. Comp. Neurol. 173, 147–164.
Orioli, P.J. and Strick, P.L. (1989) Cerebellar connections with the motor cortex and the arcuate premotor area: an analysis employing retrograde transneuronal transport of WGA-HRP. J. Comp. Neurol. 288, 621–626.
Kievet, J. and Kuypers, H.G.J.M. (1977) Organization of the thalamocortical connections to the frontal lobe in the rhesus monkey. Exp. Brain Res. 29, 299–322.
Yeterian, E.H. and Pandya, D.N. (1985) Corticothalamic connections of the posterior parietal cortex in the rhesus monkey. J. Comp. Neurol. 237, 408–426.
Yeterian, E.H. and Pandya, D.N. (1989) Thalamic connections of the cortex of the superior temporal sulcus in the rhesus monkey. J. Comp. Neurol. 282, 80–97.
Vogt, B.A. and Pandya, D.N. (1987) Cingulate cortex of the rhesus monkey: II. Cortical afferents. J. Comp. Neurol. 262, 271–289.
Schmahmann, J.D. and Pandya, D.N. (1990) Anatomical investigation of projections from thalamus to the posterior parietal association cortices in rhesus monkey. J. Comp. Neurol. 295, 299–326.
Siwek, D.F. and Pandya, D.N. (1991) Prefrontal projections to the mediodorsal nucleus of the thalamus in the rhesus monkey. J. Comp. Neurol. 312, 509–524.
Giguere, M. and Goldman Rakic, P.S. (1988) Mediodorsal nucleus: areal, laminar, and tangential distribution or afferents and efferents in the frontal lobe of rhesus monkeys. J. Comp. Neurol. 277, 195–213.
Barbas, H., Haswell Henion, T.H., and Cermon, C.R. (1991) Diverse thalamic projections to the prefrontal cortex in the rhesus monkey. J. Comp. Neurol. 313, 65–94.
Middleton, F.A. and Strick, P.L. (1994) Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science 266, 458–451.
Middleton, F.A. and Strick, P.L. (1997) Cerebellar output channels, in The Cerebellum and Cognition, Schmahmann (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 61–82.
Mackel, R. (1987) The role of the monkey sensory cortex in the recovery from cerebellar injury. Exp. Brain Res. 66, 638–652.
Metter, E.J., Kempler, D., Jackson, C.A., et al. (1987) Cerebellar glucose metabolism in chronic aphasia. Neuroogy 37, 1599–1606.
Botez-Marquard, T. and Botez, M.I. (1997) Olivopontocerebellar atrophy and Friedreich’s ataxia: neuropsychological consequences of bilateral versus unilateral cerebellar lesions, in The Cerebellum and Cognition (Schmahmann, J.D., ed.), Academic Press, San Diego, pp. 387–410.
Schmahmann, J.D. and Sherman, J.C. (1998) The cerebellar cognitive affective syndrome. Brain 121, 5661–5 669. (see editorial, Brain 1998; 121, 545–546.)
Knoepfel, H.K. and Macken, J. (1947) Le syndrome psycho-organique dans les heredo-ataxies. J. Belge. Neurol. Psychiat. 47, 314–323.
Kish, S.J., El-Awar, M., Schut, L., Leach, L., Oscar-Berman, M., and Freedman, M. (1988) Cognitive deficits in olivopontocerebellar atrophy: implications for the cholinergic hypothesis of Alzheimer’s dementia. Ann. Neurol. 24, 200–206.
Bracke-Tolkmitt, R., Linden, A., Canavan, A.G.M., et al. (1989) The cerebellum contributes to mental skills. Behay. Neurosci. 103, 442–446.
Grafman, J., Litvan, I., Massaquoi, S., Stewart, M., Sirigu, A., and Hallett, M. (1992) Cognitive planning deficit in patients with cerebellar atrophy. Neurology 42, 1493–1496.
Appollonio, I.M., Grafman, J., Schwartz, V., Massaquoi, S., and Hallett, M. (1993) Memory in patients with cerebellar degeneration. Neurology 43, 1536–1544.
Geschwind, D.H. (1999) Focusing attention on cognitive impairment in spinocerebellar ataxia. Arch Neurol. 56, 20–22.
Wallesch, C.-W. and Horn, A. (1990) Long-term effects of cerebellar pathology on cognitive functions. Brain Cogn. 14, 19–25.
Botez-Maquard, T., Leveille, J., and Botez, M.I. (1994) Neuropsychological functioning in unilateral cerebellar damage. Can. J. Neurol. Sci. 21, 353–357.
Silveri, M.C., Leggio, M.G., and Molinari, M. (1994) The cerebellum contributes to linguistic production: a case of agrammatic speech following a right cerebellar lesion. Neurology 44, 2047–2050.
Fiez, J.A., Petersen, S.E., Cheney, M.K., and Raichle, M.E. (1992) Impaired non-motor learning and error detection associated with cerebellar damage. A single case study. Brain 115, 155–178.
Malm, J., Kristensen, B., Karlsson, T., Carlberg, B., Fagerlund, M., and Olsson, T. (1998) Cognitive impairment in young adults with infratentorial infarcts. Neurology 51, 433–440.
Neau, J.P., Arroyo-Anllo, E., Bonnaud, V., Ingrand, P., and Gil, R. (2000) Neuropsychological disturbances in cerebellar infarcts. Acta Neurol. Scand. 102,363–370.
Parvizi, J., Anderson, S.W., Martin, C.O.. Damasio, H., and Damasio, A.R. (2001) Pathological laughter and crying: a link to the cerebellum. Brain 124, 1708–1719.
Gomez Beldarrain, M., Garcia-Monco, J.C., Quintana, J.M., Llorens, V., and Rodeno, E. (1997) Diaschisis and neuropsychological performance after cerebellar stroke. Eur. Neurol. 37, 82–89.
Schmahmann, J.D. and Sherman, J.C. The cerebellar cognitive affective syndrome. (1998) Brain 121, 2203–2205.
Botez-Marquard, T., Léveillé, J., and Botez, M.I. (1994) Neuropsychological functioning in unilateral cerebellar damage. Can. J. Neurol. Sci. 21, 353–357.
Dennis, M., Spiegler, B.J., Hetherington, C.R., and Greenberg, M.L. (1996) Neuropsychological sequelae of the treatment of children with medulloblastoma. J. Neurooncol. 29, 91–101.
Waber, D.P. and Holmes, J.M. (1985) Assessing children’s copy production of the Rey-Ostereith complex figure. J. Clin. Exp. Neuropsychol. 7, 264–280.
Duffner, P.K., Cohen, M.E., and Thomas, P. (1983) Late effects of treatment on the intelligence of children with posterior fossa tumors. Cancer 51, 233–237.
Glauser, T.A. and Packer, R.J. (1991) Cognitive deficits in long-term survivors of childhood brain tumors. Child’s Nerv. Sys. 7, 2–12.
Radcliffe, J., Packer, R.J., Atkins, T.E., et al. (1992) Three- and four-year cognitive outcome in children with noncortical brain tumors treated with whole-brain radiotherapy. Ann. Neural. 32. 551–554.
Levisohn, L., Cronin-Golomb, A., and Schmahmann, J.D. (2000) Neuropsychological consequences of cerebellar tumour resection in children: cerebellar cognitive affective syndrome in a paediatric population. Brain 123, 1041–1050.
Riva, D. and Giorgi, C. (2000) The cerebellum contributes to higher functions during development: evidence from a series of children surgically treated for posterior fossa tumours. Brain 123, 1051–1061.
Wisoff, J.H. and Epstein, F.J. (1984) Pseudobulbar palsy after posterior fossa operation in children. Neurosurgery 15, 707–709.
Pollack, I.F., Polinko, P., Albright, A.L., Towbin, R., and Fritz, C. (1995) Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology. Neurosurgery 37, 885–893.
Catsman-Berrevoets, C.E., Van Dongen, H.R., Mulder, P.G., Pazy Geuze, D., Paquier, P.F., and Lequin, M.H. (1999) Tumour type and size are high risk factors for the syndrome of “cerebellar” mutism and subsequent dysarthria. J. Neurol. Neurosurg. Psychiatry 67, 755–757.
Dunwoody, G.W., Alsagoff, Z.S., and Yuan, S.Y. (1997) Cerebellar mutism with subsequent dysarthria in an adult: case report. Br. J. Neurosurg. 11, 161–163.
Berquin, P.C., Giedd, J.N., Jacobsen, L.K., et al. (1998) Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study. Neurology 50, 1087–1093.
Mostofsky, S.H., Mazzacco, M.M., Aakalu, G., Warsofsky, I.S., Denckla, M.B., and Reiss, A.L., et al. (1998) Decreased cerebellar posterior vermis size in fragile X syndrome: correlation with neurocognitive performance. Neurology 50, 121–130.
Castellanos, F.X., Giedd, J.N., Berquin, P.C., et al. (2001) Quantitative brain magnetic resonance imaging in girls with attention-deficit/hyperactivity disorder. Arch. Gen. Psychiatry 58, 289–295.
Allin, M., Matsumoto, H., Santhouse, A.M., et al. (2001) Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term. Brain 124, 60–66.
Nicolson, R.I., Fawcett, A.J., Berry, EL., Jenkins, I.H., Dean, P., and Brooks, D.J. (1999) Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet 353. 1662–1667
Glickstein, M. (1994) Cerebellar agenesis. Brain 117, 1209–1212.
Gardner, R.J., Coleman, L.T., Mitchell, L.A., et al. (2001) Near-total absence of the cerebellum. Neuropediatrics 32, 62–68.
Chheda, M.G., Sherman, J.C., and Schmahmann, J.D. (2002) Neurologic, psychiatric and cognitive manifestations in cerebellar agenesis. Neurology 58(Suppl. 3), 356.
Heath, R.G., Franklin, D.E., and Shraberg, D. (1979) Gross pathology of the cerebellum in patients diagnosed and treated as functional psychiatric disorders. J. Nerv. Ment. Dis. 167, 585–592.
Pollak, L., Klein, C., Rabey, J.M., and Schiffer, J. (1996) Posterior fossa lesions associated with neuropsychiatric symptomatology. Int. J. Neurosci. 87, 119–126.
Lippman, S., Manshadi, M., Baldwin, H., Drasin, G., Rice, J., and Alrajech, S. (1981) Cerebellar vermis dimensions on computerized tomographic scans of schizophrenic and bipolar patients. Am. J. Psychiatry 139. 667–668.
Moriguchi, I. (1981) A study of schizophrenic brains by computerized tomography scans. Folia. Psychiatry Neurol. Jpn. 35, 55–72.
Loeber, R.T., Cintron, C.M., and Yurgelun-Todd, D.A. (2001) Morphometry of individual cerebellar lobules in schizophrenia. Am. J. Psychiatry 158, 952–954.
Ichimiya, T., Okubo, Y., Suhara, T., and Sudo, Y. (2001) Reduced volume of the cerebellar vermis in neurolepticnaive schizophrenia. Biol. Psychiatry 49, 20–27.
Volz, H., Gaser, C., and Sauer, H. (2000) Supporting evidence for the model of cognitive dysmetria in schizophrenia -a structural magnetic resonance imaging study using deformation-based morphometry. Schizophr. Res. 46. 45–56.
Andreasen, N.C., O’Leary, D.S., Cizadlo, T., et al. (1996) Schizophrenia and cognitive dysmetria: a positronemission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc. Natl. Acad. Sci. USA 93, 9985–9990.
Staal, W.G., Hulshoff Pol, H.E., Schnack, H.G., van Haren, N.E., Seifert, N., and Kahn, R.S. (2001) Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome spectrum. Am. J. Psychiatry 158. 1140–1142.
Courchesne, E., Yeung-Courchesne, R., Press, G.A., Hesselink, J.R., and Jernigan, T.L. (1988) Hypoplasia of cerebellar vermal lobules VI and VII in autism. N. Engl. J. Med. 318, 1349–1354.
Murakami, J.W., Courchesne, E., Press, G.A., Yeung-Courchesne, R., and Hesselink, J.R. (1989) Reduced cerebellar hemisphere size and its relationship to vermal hypoplasia in autism. Arch Neurol. 46, 689–694.
Kemper, T.L. and Bauman, M. (1998) Neuropathology of infantile autism. J. Neuropathol. Exp. Neurol. 57,645–652.
Heath, R.G. (1977) Modulation of emotion with a brain pacemaker. Treatment for intractable psychiatric illness. J. Nerv. Ment. Dis. 165, 300–317.
Cooper, I.S., Riklan, M., Amin, I., and Cullinan, T. (1978) A long-term follow-up study of cerebellar stimulation for the control of epilepsy, in Cerebellar Stimulation in Man (Cooper, I.S., ed.), Raven Press, New York, pp. 19–38.
Berman, A.J., Berman, D., and Prescott, J.W. (1974) The effects of cerebellar lesions on emotional behavior in the rhesus monkey, in The Cerebellum Epillepsy and Behavior (Cooper, I.S., Riklan, M., and Snider, R.S., eds.), Plenum Press, New York, pp. 277–284.
Reiman, E.M., Raichle, M.E., Robins, E., et al. (1989) Neuroanatomical correlates of a lactate-induced anxiety attack. Arch. Gen. Psychiatry 46, 493–500.
Lane, R.D., Reiman, E.M., Ahern, G.L., Schwartz, G.E., and Davidson, R.J. (1997) Neuroanatomical correlates of happiness, sadness, and disgust. Am. J. Psychiatry 154, 926–933.
Beauregard, M., Leroux, J.M., Bergman, S., et al. (1998) The functional neuroanatomy of major depression: an fMRI study using an emotional activation paradigm. Neuroreport 9, 3253–3258.
Desmond, J.E. and Fiez, J.A. (1998) Neuroimaging studies of the cerebellum: language, learning and memory. Trends Cog. Sci. 2, 355–362.
Schmahmann, J.D., Loeber, R.T., Marjani, J., and Hurwitz, A.S. (1998) Topographic organization of cognitive function in the human cerebellum. A meta-analysis of functional imaging studies. Neuroimage 7, S721.
Schmahmann, J.D. (1994) The cerebellum in autism: clinical and anatomic perspectives, in The Neurobiology of Autism (Bauman, M.L. and Kemper, T.L., eds.), Johns Hopkins University Press, Baltimore, pp. 195–226.
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Schmahmann, J.D. (2003). The Role of the Cerebellum in Cognition and Emotion. In: Bédard, MA., Agid, Y., Chouinard, S., Fahn, S., Korczyn, A.D., Lespérance, P. (eds) Mental and Behavioral Dysfunction in Movement Disorders. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-326-2_5
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