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Cortical-Limbic-Striatal Dysfunction in Depression

Converging Findings in Basal Ganglia Diseases and Primary Affective Disorders

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Mental and Behavioral Dysfunction in Movement Disorders

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Abstract

There is growing evidence that a complex functional–anatomical network subserves mood regulation and emotional processing under both normal and pathological conditions (1–9). Normal emotions are multidimensional processes involving the expression of interactive, but distinct behavioral elements, e.g., feelings and moods, arousal and somatic states, cognitive evaluations and interpretations—all integral to any specific emotional state. The basic nature of these behaviors suggests a certain neurolocalization, although the specifics have not been completely characterized (1,2,4,5,10). Given that normal circuits mediating these behaviors are not yet fully understood, a meaningful biological construct of “emotion disorders” must anticipate distinct neuroanatomical pathways for each of these component behaviors, as well as accommodate a system where these separate pathways are able to differentially interact in the expression of various pathological emotional states (2,7,11).

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Authors
  1. Taresa L. Stefurak MSc, MD, FRCPC
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  2. Helen S. Mayberg MD, FRCPC
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Editors and Affiliations

  1. Université du Québec à Montréal, Montréal, Canada

    Marc-André Bédard MSc, PhD

  2. Hôpital de la Salpêtrière, Paris, France

    Yves Agid MD, PhD

  3. Université de Montréal, Montréal, Canada

    Sylvain Chouinard MD  & Paul Lespérance MD, MSc  & 

  4. Columbia University, New York, NY, USA

    Stanley Fahn MD

  5. Tel-Aviv University Medical School, Tel-Aviv, Israel

    Amos D. Korczyn MD, MSc

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Stefurak, T.L., Mayberg, H.S. (2003). Cortical-Limbic-Striatal Dysfunction in Depression. In: Bédard, MA., Agid, Y., Chouinard, S., Fahn, S., Korczyn, A.D., Lespérance, P. (eds) Mental and Behavioral Dysfunction in Movement Disorders. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-326-2_25

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  • DOI: https://doi.org/10.1007/978-1-59259-326-2_25

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-372-5

  • Online ISBN: 978-1-59259-326-2

  • eBook Packages: Springer Book Archive

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