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Mood Disorders and the Globus Pallidus

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Book cover Mental and Behavioral Dysfunction in Movement Disorders

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Abstract

Mood disorders, including mania and depression, have been linked to abnormal cortical metabolism. For example, studies of patients with primary depressive disorders have consistently demonstrated frontal dysfunction (1). These frontal areas project to subcortical areas, traversing distinct functionally segregated parallel corticostriatopallidothalamocortical (CSPTC) circuits, which project back to the frontal lobe (2). Information processed in these CSPTC pathways can profoundly influence frontal function in a manner consistent with observed depressive pathophysiology (3,4). Because the globus pallidus (GP) is positioned at the heart of CSPTC circuitry, the relation of the pallidum to depressive disorders is worth considering. Consequently, this chapter explores this relationship from hodological and clinical perspectives.

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Authors
  1. Edward C. Lauterbach MD, FANPA, FAPA
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Editors and Affiliations

  1. Université du Québec à Montréal, Montréal, Canada

    Marc-André Bédard MSc, PhD

  2. Hôpital de la Salpêtrière, Paris, France

    Yves Agid MD, PhD

  3. Université de Montréal, Montréal, Canada

    Sylvain Chouinard MD  & Paul Lespérance MD, MSc  & 

  4. Columbia University, New York, NY, USA

    Stanley Fahn MD

  5. Tel-Aviv University Medical School, Tel-Aviv, Israel

    Amos D. Korczyn MD, MSc

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Lauterbach, E.C. (2003). Mood Disorders and the Globus Pallidus. In: Bédard, MA., Agid, Y., Chouinard, S., Fahn, S., Korczyn, A.D., Lespérance, P. (eds) Mental and Behavioral Dysfunction in Movement Disorders. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-326-2_24

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  • DOI: https://doi.org/10.1007/978-1-59259-326-2_24

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